65840-98-4

Upstream product

• 10523-40-7 3-Jod-6-methyl-4'-methoxy-flavanon 
• 29976-77-0 6-methyl-4'-methoxyflavone 
• 72149-92-9 3-bromo-4'-methoxy-6-methylflavanone 
• 22129-40-4 2'-hydroxy-4-methoxy-5'-methylchalcone dibromide 
• 29976-81-6 2-anisoyloxy-5-methylacetophenone 
• 16635-13-5 2'-hydroxy-4-methoxy-5'-methylchalcone 

Relevant academic research and scientific papers

Synthesis of pyrazole and isoxazole in triethanolamine medium

Reactions of 2′-hydroxy chalcone dibromides 2a-1 with phenyl hydrazine and hydrazine hydrate afford pyrazoles 1a-1 and with hydroxylamine hydrochloride give isoxazoles 5a-f in triethanolamine medium. Similarly reaction of β-diketone 3b-e with phenyl hydra

PIRAZOLE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

The present invention relates to pyrazoles of formula (I) which are modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The

Reactions of 3-Bromoflavanones with Hydrazine Hydrate

3-Bromoflavanones (I) react with hydrazine hydrate in ethanol to produce pyrazoles (V).The same reaction mixture after 48 hr at room temperature affords pyrazoles (V) and flavones (IV).In acetic acid medium, at room temperature, the reaction products are 3-bromoflavanone hydrazones (III) and flavone azines (II).However, when the reaction mixture is heated, only flavone azines (II) are formed.

Reaction of 3-Iodoflavanones with Hydrazine Hydrate & Phenylhydrazine: Synthesis of Pyrazoles

3-Iodoflavanones (IIa-d), obtained from 2'-hydroxy-4-methoxychalkones and ICl in acetic acid, when reacted with N2H4 * H2O in ethanol at room temperature give 3,5-diarylpyrazoles (IIIa-d) while with C6H5NH-NH2 * HCl in pyridine, 3,5-diaryl-1-phenylpyrazoles (IVa-d) are obtained.The identity of III and IV has been confirmed by independent and unambiguous synthesis of these pyrazoles from 2-hydroxydibenzoylmethanes.