16635-13-5

Upstream product

• 22129-40-4 2'-hydroxy-4-methoxy-5'-methylchalcone dibromide 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 29976-88-3 3-(2-hydroxy-5-methylphenyl)-5-(4-methoxyphenyl)-Δ²-isoxazoline 
• 37689-59-1 2-[5-(4-methoxy-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-4-methyl-phenol 
• 10523-40-7 3-Jod-6-methyl-4'-methoxy-flavanon 
• 65612-70-6 4'-methoxy-6-methylflavanone oxime 
• 22129-40-4 2'-hydroxy-4-methoxy-5'-methylchalcone dibromide 
• 29976-77-0 6-methyl-4'-methoxyflavone 
• 29976-66-7 2'-hydroxy-3'-bromo-4-methoxy-5'-methylchalcone 
• 27770-80-5 2-(4-methoxyphenyl)-6-methylchroman-4-one 
• 75328-78-8 3-chloro-2-(4-methoxy-phenyl)-6-methyl-chromen-4-one 
• 81633-04-7 (1-Brom-2-hydroxy-2-(4-methoxy-phenyl)-ethyl)-(2-hydroxy-5-methyl-phenyl)-keton 
• 130956-61-5 2'-hydroxy-4-methoxy-5'-methyl-3'-nitro-trans-chalcone 
• 132314-54-6 (E)-3-(4-Methoxy-phenyl)-1-(5-methyl-3-nitro-2-nitrooxy-phenyl)-propenone 
• 58434-59-6 2'-hydroxy-4-methoxy-5'-methylchalcone oxime 
• 107095-35-2 3-Anisyl-5-(2-hydroxy-5-methylphenyl)-Δ²-pyrazoline 

Relevant academic research and scientific papers

Synthesis, anticancer, structural, and computational docking studies of 3-benzylchroman-4-one derivatives

A series of 3-Benzylchroman-4-ones were synthesized and screened for anticancer activity by MTT assay. The compounds were evaluated against two cancerous cell lines BT549 (human breast carcinoma), HeLa (human cervical carcinoma), and one noncancerous cell

Absorption and fluorescent studies of 3-hydroxychromones

The synthesis and spectral studies of variously substituted 3-hydroxychromones have been carried out. A key relationship between the structural motif of synthesized 3-hydroxychromones (3-HCs) and their fluorescent properties was found. The chromones substituted with electron-donating group at 4′-position expressed the red shift of the N and T band and also exhibited the increased fluorescent intensity ratio while the chromones with electron-withdrawing group showed the blue shift of the N and T band. Therefore, these 3-HCs may behave as the possible fluorescent probes.

Synthesis and biological activities of some flavones

Chalcones are synthesized by a base catalyzed Claisen Schmidt condensation reaction and then treated with dimethylsulphoxide in presence of iodine to get flavones. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, P. aeruginosa, S. epidermidis and B. subtilis. All the flavones showed moderate to good activity. The structures of these compounds were confirmed by IR, UV, 1H NMR, Mass and elemental analysis.

An unexpected rearrangement-hydration reaction sequence of 2H-chromenes to dihydrochalcones under catalysis of HAuCl4

2-Aryl-2H-chromenes in aqueous DCM medium under catalysis of HAuCl 4 are converted into 3-(2-hydroxyaryl)-1-arylpropan-1-ones through hydration-rearrangement reaction sequence in very good yield. The key step probably involves the [1,5] hydride shift followed by the hydrolysis under the reaction condition. The notable advantages of this method are operational simplicity and ease of isolation of products and also provide a pathway to convert the chalcone into DHCs with the transposition of carbonyl group. 2012 Elsevier Ltd. All rights reserved.

Synthesis of some new pyrimidines and isoxazolines and their pharmacological activity

The condensation of 5-methyl-2-hydroxy acetophenone 1 with different aromatic aldehydes in anhyd ethanol in presence of strong alkali gave 1-(5′-methyl-2′-hydroxy phenyl-1′-yl)-3-substituted arylidene-2-propen-1-ones (2a-d). Compounds (2a-d) underwent cyc

Studies on ruthenium(III) chalconate complexes containing PPh 3/AsPh3

The reactions of [RuX3(EPh3)3] (X = Cl or Br; E = P or As) with 2′-hydroxychalcones in benzene under reflux led to the formation of [RuX2(EPh3)2(L)] (X = Cl or Br; E = P or As; L = chalcona

Synthesis and cytotoxic activity of 4-aryl-4H-chromeno[4,3-d] [1,2,3] selenadiazoles

Fourteen 4-Aryl-4H-chromeno[4,3-d][1,2,3] selenadiazole derivatives were synthesized by the reaction of fla-vonone-4-semicarbazones with SeO2. The structures of the target compounds 1a-n were elucidated by 1H NMR, IR spectra, ESI-MS and elemental analyses. The preliminary cytotoxic activities of 1a-n against K562, KB, A549, SMC-7721 and SGC-7901 cell lines were evaluated by MTT method, indicating that most compounds displayed moderate to good antiproliferative activities against K562 and KB cell lines. Compounds 1m and 1n, the most potent ones, were promising template for development of novel potent antitumor agents.

Debromination of Chalcone Dibromide and Stilbene Dibromide with Sodium Hydrogen Sulphide

Sodium hydrogen sulphide debrominated chalcone dibromide and α-bromo-β-hydroxychalcone and also stilbene dibromide in methanol to chalcone and stilbene, respectively.