29976-77-0Relevant articles and documents
Divergent synthesis of flavones and aurones via base-controlled regioselective palladium catalyzed carbonylative cyclization
Xu, Shan,Sun, Huaming,Zhuang, Mengyuan,Zheng, Shaohua,Jian, Yajun,Zhang, Weiqiang,Gao, Ziwei
, p. 264 - 270 (2018/05/04)
A regioselective approach for construction of 5-membered and 6-membered flavonoid is established by Pd catalyzed carbonylative cyclization of 2-iodophenol with terminal alkynes using different amine bases under mild reaction condition. The catalytic experiments found that piperazine preferentially accelerate 6-endo cyclization, and triethylamine mediated Pd catalyzed 5-exo cyclization. Under optimized reaction condition, Pd catalyzed carbonylative protocol successfully applied for the diverse structures of 39 examples in good to excellent yield and regioselectivity.
Iodine catalyzed cascade synthesis of flavone derivatives from 2'-allyloxy-α,β-dibromochalcones
Nawghare, Beena R.,Gaikwad, Sunil V.,Raheem, Abdul,Lokhande, Pradeep D.
, p. 2284 - 2286 (2014/07/22)
Synthesis of flavones from 2'-allyloxy-α, β-dibromochalcones has been described. The iodine induced oxidative cyclization of 2'-allyloxy-α, β-dibromochalcones results into the formation of 3-bromoflavanones which ultimately gives flavones. Dehydrobromination of 3-bromoflavanone to give flavone is the preferred reaction over dehydrogenation.
Synthesis and biological activities of some flavones
Sawant,Gill,Nirwan
, p. 297 - 300 (2013/09/24)
Chalcones are synthesized by a base catalyzed Claisen Schmidt condensation reaction and then treated with dimethylsulphoxide in presence of iodine to get flavones. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, P. aeruginosa, S. epidermidis and B. subtilis. All the flavones showed moderate to good activity. The structures of these compounds were confirmed by IR, UV, 1H NMR, Mass and elemental analysis.
