29976-77-0

Usage

Uses

Used in Pharmaceutical Industry:
4'-METHOXY-6-METHYLFLAVONE is used as a therapeutic agent for its anti-cancer properties. It has been studied for its potential to inhibit the growth and progression of various types of cancer, making it a valuable compound in the development of cancer treatments.
Used in Nutraceutical Industry:
4'-METHOXY-6-METHYLFLAVONE is used as a natural remedy for various health conditions due to its antioxidant and anti-inflammatory properties. It can be incorporated into dietary supplements and functional foods to support overall health and well-being.
Used in Cosmetic Industry:
4'-METHOXY-6-METHYLFLAVONE is used as an active ingredient in skincare products for its anti-inflammatory and antioxidant properties. It can help protect the skin from environmental damage, reduce inflammation, and promote skin health.
Used in Research and Development:
4'-METHOXY-6-METHYLFLAVONE is used as a subject of study in scientific research to explore its potential therapeutic applications further. Its anti-cancer, anti-inflammatory, and neuroprotective properties make it an interesting compound for researchers to investigate its mechanisms of action and potential uses in various health conditions.

Upstream product

• 64-17-5 ethanol 
• 60904-74-7 2-(4-methoxy-benzylidene)-5-methyl-benzofuran-3-one 
• 151-50-8 potassium cyanide 
• 127-08-2 potassium acetate 
• 14221-83-1 (+/-)-3t-bromo-2r-(4-methoxy-phenyl)-6-methyl-chroman-4-one 
• 14221-83-1 (+/-)-3c-bromo-2r-(4-methoxy-phenyl)-6-methyl-chroman-4-one 
• 65612-70-6 4'-methoxy-6-methylflavanone oxime 
• 16635-13-5 2'-hydroxy-4-methoxy-5'-methylchalcone 
• 27770-80-5 2-(4-methoxyphenyl)-6-methylchroman-4-one 
• 72149-92-9 3-bromo-4'-methoxy-6-methylflavanone 
• 105166-57-2 2-Hydroxy-benzoic acid [2-(4-methoxy-phenyl)-6-methyl-chroman-(4E)-ylidene]-hydrazide 
• 201230-82-2 carbon monoxide 
• 16188-57-1 2-iodo-4-methylphenol 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 75328-78-8 3-chloro-2-(4-methoxy-phenyl)-6-methyl-chromen-4-one 
• 35947-90-1 3-bromo-4'-methoxy-6-methylflavone 
• 29976-91-8 3-(2-hydroxy-5-methylphenyl)-5-(4-methoxyphenyl)isoxazole 
• 36695-31-5 (3-hydroxy-5-methyl-benzofuran-2-yl)-(4-methoxy-phenyl)-methanone 
• 6971-17-1 3-hydroxy-2-(4-methoxy-phenyl)-6-methyl-chromen-4-one 
• 115663-24-6 N-acetoxy-4'-methoxy-6-methylflavone oxime 
• 140885-92-3 Acetic acid 2-[3-(4-methoxy-phenyl)-isoxazol-5-yl]-4-methyl-phenyl ester 
• 4010-47-3 (3-hydroxy-5-methyl-benzofuran-2-yl)-(4-methoxy-phenyl)-ketone 
• 65840-98-4 3-(2-hydroxy-5-methylphenyl)-5-(4-methoxyphenyl)pyrazole 
• 136764-53-9 1a,7a-Dihydro-5-methyl-1a-(4-methoxyphenyl)-7H-oxireno<1>benzopyran-7-one 
• 115663-23-5 4'-methoxy-6-methylflavone oxime 
• 140885-83-2 5-(2-hydroxy-5-methylphenyl)-3-(4-methoxyphenyl)isoxazole 
• 140885-97-8 6-methyl-2-(4-methoxyphenyl)-4H-1-benzopyran-4-thione 
• 29976-78-1 8-bromo-4'-methoxy-6-methylflavone 

Relevant academic research and scientific papers

Divergent synthesis of flavones and aurones via base-controlled regioselective palladium catalyzed carbonylative cyclization

A regioselective approach for construction of 5-membered and 6-membered flavonoid is established by Pd catalyzed carbonylative cyclization of 2-iodophenol with terminal alkynes using different amine bases under mild reaction condition. The catalytic experiments found that piperazine preferentially accelerate 6-endo cyclization, and triethylamine mediated Pd catalyzed 5-exo cyclization. Under optimized reaction condition, Pd catalyzed carbonylative protocol successfully applied for the diverse structures of 39 examples in good to excellent yield and regioselectivity.

An efficient oxidative conversion of 2-aryl-2H-chromenes to the corresponding flavones by tert-butylhydroperoxide and copper bromide

A simple and efficient method has been developed for the facile oxidation of chromenes to the corresponding flavones by tert-butylhydroperoxide (TBHP) in the presence of copper(II) bromide catalyst in toluene at 80 °C in a very short time. The reaction demonstrates excellent reactivity, functional group tolerance, and good to excellent yields without using conventional strong oxidizing agents.

Iodine catalyzed cascade synthesis of flavone derivatives from 2'-allyloxy-α,β-dibromochalcones

Synthesis of flavones from 2'-allyloxy-α, β-dibromochalcones has been described. The iodine induced oxidative cyclization of 2'-allyloxy-α, β-dibromochalcones results into the formation of 3-bromoflavanones which ultimately gives flavones. Dehydrobromination of 3-bromoflavanone to give flavone is the preferred reaction over dehydrogenation.

Ecofriendly bromination of chalcones and synthesis of flavones using grinding technique

Selective bromination of chalcones and 2'-hydroxychalcones has been carried out with ammonium bromide and ammonium persulphate using grinding technique at RT under aqueous moist condition to give α,β-dibromochalcones and α,β-dibromo-2'- hydroxychalcones respectively. α,β- Dibromo-2'-hydroxychalcones have been cyclodehydrobrominated with barium hydroxide moist and ethanol at RT to give flavones using grinding technique.

Synthesis and biological activities of some flavones

Chalcones are synthesized by a base catalyzed Claisen Schmidt condensation reaction and then treated with dimethylsulphoxide in presence of iodine to get flavones. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coilt P. aeruginosa, S. epidermidis and B. subtilis. All the flavones showed moderate to good activity. The structures of these compounds were confirmed by IR, UV, 1H NMR, Mass and elemental analysis.

An efficient synthesis of 3-bromoflavones under solvent free conditions using grinding technique

Selective bromination of 1-(2-hydroxyphenyl)-3-phenylpropane- 1,3-diones has been carried out with ammonium bromide and ammonium persulphate at room temperature using grinding technique under solvent free conditions to give 2-bromo derivatives which on cyclodehydration with p-toluenesulphonic acid under grinding conditions give 3-bromoflavones. Also, flavones on bromination using above mentioned conditions give 3-bromoflavones directly.

Synthesis and biological activities of some flavones

Chalcones are synthesized by a base catalyzed Claisen Schmidt condensation reaction and then treated with dimethylsulphoxide in presence of iodine to get flavones. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, P. aeruginosa, S. epidermidis and B. subtilis. All the flavones showed moderate to good activity. The structures of these compounds were confirmed by IR, UV, 1H NMR, Mass and elemental analysis.

Oxidative cyclisation of 2′-hydroxychalcones using sodium tellurite: Synthesis of flavones

A simple and very efficient method for the oxidative cyclisation of 2′-hydroxychalcones with sodium tellurite in dimethylsulphoxide has been developed which could provide a simple route for the synthesis of flavones and also the required compound obtained as the sole product in a very high yield.

Use of Flavone Compounds as Potassium Channel Inhibitors

This invention provides a method for treating or preventing human atrial arrhythmia (fibrillation) using the leading flavone compound acacetin, and its derivatives and analogues that inhibit the ultra-rapidly-activating delayed rectifier potassium current (IKur or IKsus), transient outward potassium (Ito), and acetylcholine-activated potassium current (IK.ACh).

Sodium selenite-dimethylsulfoxide: a highly efficient reagent for dehydrogenation

Sodium selenite in dimethylsulfoxide is a highly efficient reagent for dehydrogenation reactions and can be used under both thermal as well as microwave irradiation conditions. Using this reagent benzoins have been dehydrogenated to benzils, flavanones to flavones and 2'-hydroxy chalcones have been converted into flavones by cyclodehydrogenation.