65896-28-8

Basic information

• Product Name: 1,8-Naphthyridine-2,7-dicarboxaldehyde
• Synonyms: 1,8-Naphthyridine-2,7-dicarboxaldehyde
• CAS NO: 65896-28-8
• Molecular Formula: C₁₀H₆N₂O₂
• Molecular Weight: 186.16684
• Mol File: 65896-28-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 225-227 °C
• Boiling Point: 408.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.396±0.06 g/cm3(Predicted)
• PKA: -0.63±0.30(Predicted)
• CAS DataBase Reference: 1,8-Naphthyridine-2,7-dicarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-Naphthyridine-2,7-dicarboxaldehyde(65896-28-8)
• EPA Substance Registry System: 1,8-Naphthyridine-2,7-dicarboxaldehyde(65896-28-8)

Safety Data

• Hazardous Substances Data: 65896-28-8(Hazardous Substances Data)

Usage

Chemical class

Naphthyridine derivatives

Appearance

Yellow crystalline solid

Usage

Building block in the synthesis of pharmaceuticals and agrochemicals

Field of interest

Organic chemistry and material science

Structural feature

Possesses two aldehyde groups

Application

Versatile intermediate in the preparation of complex organic molecules

Potential use

Fluorescent probe for the detection of metal ions

Relevance

Valuable tool in analytical chemistry and bioimaging applications

Upstream product

• 1569-16-0 2-methyl-[1,8]naphthyridine 
• 16867-28-0 2,6-dimethyl-4H-pyrido<1,2-a>pyrimidin-4-one 
• 53051-92-6 2,7-dimethyl-1,8-naphthyridine-4(1H)-one 
• 84670-41-7 2,7-dimethyl-4-chloro-1,8-naphthyridine 
• 1824-81-3 2-Amino-6-methylpyridine 
• 14903-78-7 2,7-dimethyl-[1,8]naphthyridine 

Downstream Products

• 313672-74-1 2,7-bis(N,N-dibenzyl-aminomethyl)-1,8-naphthyridine 
• 205885-17-2 [1,8]Naphthyridine-2,7-dicarboxylic acid bis-[((S)-1-hydroxymethyl-2-phenyl-ethyl)-amide] 
• 205885-18-3 [1,8]Naphthyridine-2,7-dicarboxylic acid bis-[((S)-1-chloromethyl-2-phenyl-ethyl)-amide] 
• 313672-72-9 2,7-bis{2-[2-(1-methyl)benzimidazolylethyl]-N-benzyl-aminomethyl}-1,8-naphthyridine 

Relevant articles and documents

A novel ruthenium (II) polypyridyl complex bearing 1,8-naphthyridine as a high selectivity and sensitivity fluorescent chemosensor for Cu2+ and Fe3+ ions

A novel ruthenium(II) polypyridyl complex bearing 1,8-naphthyridine was successfully designed and synthesized. This complex was fully characterized by EI-HRMS, NMR, and elemental analyses. The recognition properties of the complex for various metal ions were investigated. The results suggested that the complex displayed high selectivity and sensitivity for Cu2+ and Fe3+ ions with good anti-interference in the CH3CN/H2O (1:1, v/v) solution. The fluorescent chemosensor showed obvious fluorescence quenching when the Cu2+ and Fe3+ ions were added. The detection limits of Cu2+ and Fe3+ were 39.9 nmol/L and 6.68 nmol/L, respectively. This study suggested that this Ru(II) polypyridyl complex can be used as a high selectivity and sensitivity fluorescent chemosensor for Cu2+ and Fe3+ ions.

Rigid chelating dicarbene ligands based on naphthyridine-fused bisimidazolium salts

Naphthyridine-fused bisimidazolium salts were designed and synthesized for the first time. The study of the Cu(II) and Pd(II) complexes demonstrated that the deprotonated dicarbene ligands are rigid chelating C,C-ligands with strong electron-donating ability in analogy with the classic phenanthroline N,N-ligands.

Bis-styrylnaphthalene and bis-styrylnaphthyridine derivatives with high binding affinity to ?2-amyloid fibrils

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