6596-66-3

Upstream product

• 103-82-2 phenylacetic acid 
• 100-63-0 phenylhydrazine 
• 174282-49-6 trifluoro-N-(2-phenylacetyl)methanesulfonamide 
• 103-80-0 phenylacetyl chloride 
• 72358-76-0 phenylhydrazine acetate 
• 857815-07-7 N-chloroacetyl-N-phenyl-N'-phenylacetyl-hydrazine 
• 67-64-1 acetone 
• 60-29-7 diethyl ether 
• 412019-21-7 ethyl 2-acetyl-3-oxo-4-phenylbutanoate 
• 103-81-1 Benzeneacetamide 

Downstream Products

• 113136-13-3 phenyl-acetic acid-(N'-benzylidene-N-phenyl-hydrazide) 
• 857815-07-7 N-chloroacetyl-N-phenyl-N'-phenylacetyl-hydrazine 
• 92521-93-2 1-phenylacetyl-2-phenyl-5-hydroxypyrazolidine 
• 1616351-66-6 dimethyl 5-benzyl-1-phenyl-1H-pyrazole-3,4-dicarboxylate 
• 1374227-50-5 C₂₁H₂₀N₂O₂ 
• 1264108-92-0 3-phenyl-2-(2-phenylhydrazino)-4H-1-benzothiopyran-4-one 

Relevant academic research and scientific papers

A formal [3+2] cycloaddition reaction of: N -methylimidazole as a masked hydrogen cyanide: Access to 1,3-disubstitued-1 H -1,2,4-triazoles

N-Methylimidazole (NMI) can act as a masked HCN in the synthesis of 1,3-disubstitued-1H-1,2,4-triazoles via a formal cycloaddition reaction of hydrazonoyl chloride with NMI. The product was proved to be formed via an initial nucleophilic substitution of hydrazonoyl chloride with NMI following cyclization and two sequential C-N bond cleavages. This journal is

[3+3]-cycloaddition of donor-acceptor cyclopropanes with nitrile imines generated in situ: Access to tetrahydropyridazines

Donor-acceptor cyclopropanes are reacted under the influence of a Lewis acid with hydrazonyl chlorides to afford tetrahydropyridazines. Formally, this transformation can be regarded as a [3 + 3]-cycloaddition of three-membered rings and nitrile imines generated in situ. This efficient method provides fast access to a variety of structurally diverse pyridazine derivatives. The structure of a typical product was confirmed by X-ray crystallography.

Reactions of N-sulfinyltrifluoromethanesulfonamide with carboxylic acids

Phenylacetic, diphenylacetic, salicylic, and cinnamic acids reacted with N-sulfinyltrifluoromethanesulfonamide (CF3SO2NSO) to give the corresponding N-acyltrifluoromethanesulfonamides CF3SO 2NHCOR (R = PhCH

Preparation of substituted 1,2-dihydro-3H-pyrazol-3-ones from polylithiated 2′-phenylphenylacetohydrazides and aromatic esters

Several 2′-phenylphenylacetohydrazides were polylithiated with excess lithium diisopropylamide, and the resulting intermediates were condensed with several aromatic esters to afford C-acylated intermediates that were not usually isolated, but acid cyclize

Syntheses of hydrazides by a direct condensation reaction using phosphorous acid-iodine as a reagent

Aliphatic and aromatic hydrazides have been prepared in high to moderate yields by a direct condensation reaction of aliphatic or aromatic carboxylic acids with hydrazine or phenylhydrazine using phosphorous acid-iodine as reagent and pyridine as base and solvent. With aliphatic carboxylic acids, we obtained good results heating at 80-90°, for 5-6 hours, but with aromatic carboxylic acids are necessary 140-150°, for the same period of time.

Some Observations on the Brunner Reaction

Elucidation of the stereochemical course of the Brunner reaction is described.A slight modification in the procedure gives better yields and seems very promising for a more general application of this reaction.