65964-63-8

Basic information

• Product Name: 2-(4-METHOXY-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE
• Synonyms: 2-(4-METHOXY-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE
• CAS NO: 65964-63-8
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.28
• Mol File: 65964-63-8.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-METHOXY-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHOXY-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE(65964-63-8)
• EPA Substance Registry System: 2-(4-METHOXY-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE(65964-63-8)

Safety Data

• Hazardous Substances Data: 65964-63-8(Hazardous Substances Data)

Usage

Chemical class

Imidazo[1,2-a]pyridines

Substituents

Methyl and methoxy groups attached to the phenyl ring

Usage

Building block for the synthesis of various pharmaceuticals, including potential anti-cancer and anti-inflammatory agents

Significance

Valuable tool for drug discovery and development, studied for potential biological activities and pharmacological properties.

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 96155-57-6 1-(4-methoxyphenyl)ethanone O-acetyl oxime 
• 108-89-4 picoline 
• 13466-41-6 4-methyl-1H-pyridin-2-one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 121-97-1 4-Methoxypropiophenone 
• 3179-10-0 1-methoxy-4-(2-nitro-vinyl)-benzene 
• 75-52-5 nitromethane 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1283074-03-2 C₁₉H₂₄N₃O⁽¹⁺⁾*I^(1-) 
• 1017194-77-2 [2-(4-methoxyphenyl)-7-methylimidazo[1,2-a]pyridin-3-yl]acetic acid 
• 1176684-78-8 1-(2-(4-methoxyphenyl)-7-methylimidazo[1,2-a]-3-pyridinyl)-N,N-dimethylmethylamine 

Relevant articles and documents

Solvent and catalyst-free synthesis of imidazo[1,2-a]pyridines by grindstone chemistry

The present work describes the solvent and catalyst-free synthesis of imidazo[1,2-a]pyridines in excellent to nearly quantitative yields from 2-aminopyridines and a wide variety of ω-bromomethylketones using a grindstone procedure at 25°C to 30°C for 3 to

CuCl2-catalyzed N[sbnd]O bond cleavage of oxime esters: Approach to imidazoheterocycles and furo[3,2-c]chromenyl fused imidazoles

An articulate approach to a diverse set of imidazoheterocycles in good to high yields via a copper-catalyzed aza-annulation of several oxime esters with a group of 2-amino-azaarenes was developed. The above cyclization reaction probably proceeds via a single electron transfer process which embodies a new technique for creating two new C[sbnd]N bonds for imidazole ring synthesis. Gratifyingly, the implementation of this chemistry could be further stretched to the synthesis of a novel class of fused imidazoles bearing a furo[3,2-c]chromene moiety via a sequential C[sbnd]N bond formation, followed by C(sp2)-H functionalization/5-endo-dig-oxacyclization (C[sbnd]C and C[sbnd]O bonds) of in situ produced fused imidazoles with cyclic enynones in the presence of copper(II) as a π-electrophilic Lewis acid catalyst.

Formation of Methylene Linkage for N-Heterocycles: Sequential C-H and C-O Bond Functionalization of Methanol with Cosolvent Water

An iron-catalyzed methylene forming strategy is disclosed through sequential C-H and C-O bond functionalization of methanol with cosolvent water. This protocol provides an easy and novel access to methylene-tethered imidazo[1,2-a]pyridine and 2-aminopyridine analogues in a sustainable manner and represents a complementary approach to traditional methylene forming strategies.