66005-03-6

Basic information

• Product Name: 2-Propenamide, N-[(4-methylphenyl)methyl]-
• CAS NO: 66005-03-6
• Molecular Formula: C11H13NO
• Molecular Weight: 175.23
• Mol File: 66005-03-6.mol

Chemical Properties

• CAS DataBase Reference: 2-Propenamide, N-[(4-methylphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide, N-[(4-methylphenyl)methyl]-(66005-03-6)
• EPA Substance Registry System: 2-Propenamide, N-[(4-methylphenyl)methyl]-(66005-03-6)

Safety Data

• Hazardous Substances Data: 66005-03-6(Hazardous Substances Data)

Usage

Chemical class

Amide

Use

Intermediate in the synthesis of other chemicals, production of polymers and resins, production of acrylic adhesives and coatings

Physical properties

Colorless to light yellow liquid, faint odor, relatively stable under normal conditions

Importance in the chemical industry

Ability to participate in various reactions, contributes to the production of a wide range of materials

Upstream product

• 814-68-6 acryloyl chloride 
• 104-84-7 para-methylbenzylamine 
• 38460-98-9 bis(4-methylbenzyl) ether 
• 107-13-1 acrylonitrile 
• 589-18-4 4-Methylbenzyl alcohol 
• 106-42-3 para-xylene 

Relevant articles and documents

Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity

Histone deacetylases (HDACs) have been identified as promising epigenetic drug targets for the treatment of neuroblastoma and glioblastoma. In this work, we have rationally designed a novel class of peptoid-based histone deacetylase inhibitors (HDACi). A

Perfluorinated sulfonic acid resin (Nafion-H) catalysed Ritter reaction of benzyl alcohols

Perfluorinated sulfonic acid resin (Nafion-H) catalyst found to be effective in promoting the Ritter reaction of benzyl alcohols with nitriles such as acetonitrile, acrylonitrile and benzonitrile to give the corresponding N-benzylamides.

Preparation and Reactivities of Hexakisacetonitrile Iron(III) Perchlorate and Related Complexes as Strong Oxidizing Reagents

The iron(III) complexes Fe(S)6(ClO4)3, S=solvent, were prepared from Fe(H2O)6(ClO4)3 in the donor solvents.Reactions of alkylbenzenes with Fe(AN)6(ClO4)3 (AN=acetonitrile) were explored because the AN complex has the highest formal redox potential, E0=1.73 V vs.SCE, among these complexes.Oxidation of the primary alkylbenzenes by the iron(III) AN complex gave the corresponding acetamides (Table II).Oxidation of the secondary alkylbenzenes, namely, cumene, 2-phenylbutane, and 2-exo-phenylnorbornane, afforded the corresponding acetates and acetamides (Charts 2 and 3), consuming over 4-mol eq of reagent.Reactions of p-xylene and hexamethylbenzene with Fe(CH2=CHCN)6(ClO4)3 also yielded the amides 31a and 31b.These results demonstrate the applicability of the iron(III) AN complexes as a powerful reagent to oxidize organic substrates which have onset potentials of anodic current of ca. 2.0 V vs.SCE.Keywords - oxidation; primary alkylbenzene; secondary alkylbenzene; oxidizing reagent; iron(III) perchlorate solvate; hexakisacetonitrile iron(III) perchlorate; hexakisacrylonitrile iron(III) perchlorate