66053-97-2

Basic information

• Product Name: 1-(3,4-DIMETHOXY-PHENYL)-PENTAN-1-ONE
• Synonyms: 1-(3,4-DIMETHOXY-PHENYL)-PENTAN-1-ONE;1-Pentanone, 1-(3,4-diMethoxyphenyl)-
• CAS NO: 66053-97-2
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.28022
• Mol File: 66053-97-2.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(3,4-DIMETHOXY-PHENYL)-PENTAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-DIMETHOXY-PHENYL)-PENTAN-1-ONE(66053-97-2)
• EPA Substance Registry System: 1-(3,4-DIMETHOXY-PHENYL)-PENTAN-1-ONE(66053-97-2)

Safety Data

• Hazardous Substances Data: 66053-97-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthesis, p. 1216, 1991 DOI: 10.1055/s-1991-28422

Upstream product

• 109-72-8 n-butyllithium 
• 93-07-2 Veratric acid 
• 538-75-0 dicyclohexyl-carbodiimide 
• 638-29-9 n-valeryl chloride 
• 91-16-7 1,2-dimethoxybenzene 
• 109057-50-3 Pentaneselenoic acid Se-phenyl ester 
• 3943-77-9 ethyl veratrate 
• 693-03-8 n-butyl magnesium bromide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 107-08-4 1-iodo-propane 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 109-52-4 valeric acid 
• 26429-16-3 trimethylsilyl pentanoate 
• 2082-59-9 pentanoic anhydride 

Downstream Products

• 100619-32-7 3',4'-dimethoxyvalerophenone oxime 
• 2525-11-3 4-pentyl-pyrocatechol 
• 850442-84-1 1-(3,4-dimethoxyphenyl)-2-pyrrolidin-1-yl-pentan-1-one 
• 128349-87-1 1,2-dimethoxy-4-pentylbenzene 

Relevant articles and documents

Simple one pot synthesis of ketone from carboxylic acid using DCC as an activator

Simple one pot procedure for the conversion of carboxylic acid to ketone is described. Various carboxylic acids were converted to the corresponding ketones in excellent manner in presence of N,N′-dicyclohexylcarbodiimide (DCC) and organometallic reagents. Aromatic, heteroaromatic and aliphatic acids were converted to the corresponding ketones smoothly under the optimum conditions using organolithium reagents. In this process, desired products have been isolated from the crude reaction mixtures in moderate yields during the purification process.

SUBSTITUTED 6, 7-DIALKOXY-3-ISOQUINOLINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE 10 (PDE 10A)

The invention relates to compounds of the formula or a pharmaceutically acceptable salt thereof, wherein R′, R1 through R7 and Ar are as defined herein. These compounds are useful as inhibitors of phosphodiesterase 10 (PDE10A) which are useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type II diabetes, metabolic syndrome, glucose intolerance, pain and ophthalmic diseases.

SUBSTITUTED 6,7-DIALKOXY-3-ISOQUINOLINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE 10 (PDE10A)

The invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R', R1 through R7 and Ar are as defined herein. These compounds are useful as inhibitors of phosphodiesterase 10 (PDE10A) which are useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type II diabetes, metabolic syndrome, glucose intolerance, pain and ophthalmic diseases.