6606-65-1Relevant articles and documents
N-butyl cyanoacrylate synthesis. A new quality step using microwaves
Carriles, Yaquelin Ramos,Brito, Ruben Alvarez,Sanchez, Ricardo Martinez,Acevedo, Elayma Sanchez,Dominguez, Paola Rodriguez,Mueller, Wolf-Dieter
, p. 6220 - 6227 (2014)
Alkyl cyanoacrylates are interesting products for use in industry because of their properties enabling them to stick together a wide range of substrates. n-Butyl cyanoacrylate is one of the most successfully used tissue adhesives in the field of medicine because it exhibits bacteriostatic and haemostatic characteristics, in addition to its adhesive properties. At present, its synthesis is performed with good yields via Knoevenagel condensation using conventional sources of heating, but this requires a long processing time. The aim of this work was to look for a new way of synthesising n-butyl cyanoacrylate using microwave irradiation as the source of heating. This non-conventional source of heating most likely reduces the process time of the synthesis. In comparison with a conventional heating source, such as an oil bath, the results showed the advantages of this method whereby the n-butyl cyanoacrylate gave the same yield and quality with a reduction in the reaction time by a factor of 3-5-fold.
Synthesis process of alpha-n-butyl cyanoacrylate
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Paragraph 0028-0032, (2020/06/09)
The invention provides a synthesis process of alpha-n-butyl cyanoacrylate. The synthesis process comprises the following steps: reacting formaldehyde and n-butyl cyanoacetate under the action of a catalyst and a catalyst assistant to obtain a wet prepolymer; and sequentially carrying out cracking and refining on the wet prepolymer to obtain the alpha-n-butyl cyanoacrylate. By adopting the synergistic effect of a composite additive and a dispersing agent, reaction time is greatly shortened, yield is obviously increased, an oil phase and a water phase are fully mixed under the condition of no solvent reaction, interface contact is expanded, product quality is improved, product purity is greater than or equal to 99.5%, and product yield is greater than or equal to 75%.
Method for preparing glue and medical glue
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Paragraph 0082-0085; 0097; 0098, (2018/06/26)
The present invention provides a method for preparing an acrylate based adhesive in high purity, which performs a process of producing an alkyl cyanoacrylate polymer from alkyl cyanoacetate and a process of depolymerizing the alkyl cyanoacrylate polymer into monomers together to reduce the production costs.(AA) Mix alkyl alcohol with an organic solvent(BB) Add cyanoacetic acid and strong acid to the mixed solution and heating the same for esterification(CC) Remove water produced during the esterification reaction by azeotropic distillation and purify/dry the mixture(DD) Stir alkyl cyanoacetate, a crosslinking agent, and a catalyst to prepare a polymer(EE) Prepare a crude polymer from the polymer(FF) Perform catalytic depolymerization of the crude polymer to obtain a monomer-type high purity polymerCOPYRIGHT KIPO 2018