6606-65-1Relevant articles and documents
N-butyl cyanoacrylate synthesis. A new quality step using microwaves
Carriles, Yaquelin Ramos,Brito, Ruben Alvarez,Sanchez, Ricardo Martinez,Acevedo, Elayma Sanchez,Dominguez, Paola Rodriguez,Mueller, Wolf-Dieter
, p. 6220 - 6227 (2014)
Alkyl cyanoacrylates are interesting products for use in industry because of their properties enabling them to stick together a wide range of substrates. n-Butyl cyanoacrylate is one of the most successfully used tissue adhesives in the field of medicine because it exhibits bacteriostatic and haemostatic characteristics, in addition to its adhesive properties. At present, its synthesis is performed with good yields via Knoevenagel condensation using conventional sources of heating, but this requires a long processing time. The aim of this work was to look for a new way of synthesising n-butyl cyanoacrylate using microwave irradiation as the source of heating. This non-conventional source of heating most likely reduces the process time of the synthesis. In comparison with a conventional heating source, such as an oil bath, the results showed the advantages of this method whereby the n-butyl cyanoacrylate gave the same yield and quality with a reduction in the reaction time by a factor of 3-5-fold.
Synthesis process of alpha-n-butyl cyanoacrylate
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Paragraph 0028-0032, (2020/06/09)
The invention provides a synthesis process of alpha-n-butyl cyanoacrylate. The synthesis process comprises the following steps: reacting formaldehyde and n-butyl cyanoacetate under the action of a catalyst and a catalyst assistant to obtain a wet prepolymer; and sequentially carrying out cracking and refining on the wet prepolymer to obtain the alpha-n-butyl cyanoacrylate. By adopting the synergistic effect of a composite additive and a dispersing agent, reaction time is greatly shortened, yield is obviously increased, an oil phase and a water phase are fully mixed under the condition of no solvent reaction, interface contact is expanded, product quality is improved, product purity is greater than or equal to 99.5%, and product yield is greater than or equal to 75%.
Synthesis method of alpha-cyanoacrylate
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Paragraph 0038-0043; 0046-0051, (2018/05/16)
The invention provides a preparation method of alpha-cyanoacrylate. The method comprises steps as follows: alpha-cyanoacetate and paraformaldehyde or a formaldehyde water solution are subjected to a condensation reaction through programmed temperature and sufficient stirring under the condition of reduced pressure in the presence of a catalyst; water is removed after the condensation reaction ends, a polymerization inhibitor is added for distillation cracking after sufficient dewatering, sufficient stirring, vacuum pumping and temperature increasing are performed, and a cracking reaction is performed. A crude monomer obtained through the steps is rectified, and a refined alpha-cyanoacrylate monomer with higher yield and purity can be obtained. The polycondensation catalyst is a compound catalyst of triphenylphosphine and a guanidine catalyst. The method is high in efficiency and safety, has low side reactions and is environmentally friendly, and the product yield and the product purityare high.