6607-45-0

Basic information

• Product Name: (1,2-DICHLOROVINYL)BENZENE
• Synonyms: (1,2-DICHLOROVINYL)BENZENE;ALPHA,BETA-DICHLOROSTYRENE;(1,2-Dichloroethenyl)benzene;1-(1,2-Dichloroethenyl)benzene
• CAS NO: 6607-45-0
• Molecular Formula: C₈H₆Cl₂
• Molecular Weight: 173.04
• Mol File: 6607-45-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 48.5°C (estimate)
• Boiling Point: 230.44°C (rough estimate)
• Flash Point: 96.5°C
• Appearance: /
• Density: 1.2460 (estimate)
• Vapor Pressure: 0.163mmHg at 25°C
• Refractive Index: 1.5811 (estimate)
• CAS DataBase Reference: (1,2-DICHLOROVINYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: (1,2-DICHLOROVINYL)BENZENE(6607-45-0)
• EPA Substance Registry System: (1,2-DICHLOROVINYL)BENZENE(6607-45-0)

Safety Data

• Hazardous Substances Data: 6607-45-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 21, p. 489, 1991 DOI: 10.1080/00397919108016774

InChI:InChI=1/C8H6Cl2/c9-6-8(10)7-4-2-1-3-5-7/h1-6H/b8-6+

Upstream product

• 10026-13-8 phosphorus pentachloride 
• 532-27-4 1-chloroacetophenone 
• 536-74-3 phenylacetylene 
• 103-80-0 phenylacetyl chloride 
• 98-86-2 acetophenone 
• 618-34-8 1-chlorostyrene 

Downstream Products

• 5398-63-0 2,5-diphenylpyrazine 
• 65-85-0 benzoic acid 
• 5216-35-3 1,2-bis(4-chlorophenyl)ethane 
• 1857-74-5 2,3-diphenylbutane 
• 70550-40-2 (1-chlorobut-1-ene-1,3-diyl)dibenzene 
• 2726-21-8 2,3-diphenylbutane 
• 19676-39-2 (1,1,2,2-tetrachloro-ethyl)-benzene 

Relevant articles and documents

Aromatic substitution in ball mills: Formation of aryl chlorides and bromides using potassium peroxomonosulfate and NaX

Aryl chlorides and bromides are formed from arenes in a ball mill using KHSO5 and NaX (X = Cl, Br) as oxidant and halogen source, respectively. Investigation of the reaction parameters identified operating frequency, milling time, and the number of milling balls as the main influencing variables, as these determine the amount of energy provided to the reaction system. Assessment of liquid-assisted grinding conditions revealed, that the addition of solvents has no advantageous effect in this special case. Preferably activated arenes are halogenated, whereby bromination afforded higher product yields than chlorination. Most often reactions are regio- and chemoselective, since p-substitution was preferred and concurring side-chain oxidation of alkylated arenes by KHSO5 was not observed. The Royal Society of Chemistry.

Reaction of Phosphorus Pentachloride with 2-Acetylthiophene and Acetophenone

The treatment of 2-acetylthiophene with PCl5, followed by dehydrochlorination, is known to be a poor method for synthesizing 2-ethynylthiophene (1a).Reinvestigation of the reaction showed the major products to be the E- and Z- isomers of 1,2-dichloro-1-(2-thienyl)ethylene (7a), with minor amounts of 1,1-dichloro-1-(2-thienyl)ethane (3a), 1-chloro-1-(2-thienyl)ethylene (4a), 2-(chloroacetyl)thiophene, and 2-(dichloroacetyl)thiophene.The treatment of acetophenone with PCl5 yielded similar products, and the mechanism of these reactions is discussed.The major product 7a could be converted into 1a by reaction with magnesium.The yield of 4a was increased when pyridine was also used, when only 1 equiv of PCl5 was added by portions to the ketone, or when catecholphosphorus trichloride was used instead of PCl5.The best method for converting 2-acetylthiophene into 1a goes through the enol phosphonate of 2-(bromoacetyl)thiophene, which is treated with sodium amide.