5216-35-3

Basic information

• Product Name: 1,2-Bis(4-chlorophenyl)ethane
• Synonyms: 1,2-Bis(4-chlorophenyl)ethane
• CAS NO: 5216-35-3
• Molecular Formula: C₁₄H₁₂Cl₂
• Molecular Weight: 251.1511
• Mol File: 5216-35-3.mol
• Article Data: 71

Chemical Properties

• Boiling Point: 319.2°Cat760mmHg
• Flash Point: 133°C
• Appearance: /
• Density: 1.214g/cm³
• CAS DataBase Reference: 1,2-Bis(4-chlorophenyl)ethane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Bis(4-chlorophenyl)ethane(5216-35-3)
• EPA Substance Registry System: 1,2-Bis(4-chlorophenyl)ethane(5216-35-3)

Safety Data

• Hazardous Substances Data: 5216-35-3(Hazardous Substances Data)

Usage

Uses

1-Chloro-4-[2-(4-chlorophenyl)ethyl]benzene was a useful compound for studying the effect of solvent on photolysis of 3-?chloro- and 4-?chloro substituted benzyl chlorides. An impurity Clobutinol Hydrochloride (C583600(M)), which is a non-narcotic antitussive drug useful for treatment of acute respiratory diseases.

Upstream product

• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 622-95-7 4-chlorobenzyl bromide 
• 1571-08-0 methyl 4-formylbenzoate 
• 874-72-6 4-chlorobenzylmagnesium chloride 
• 75-91-2 tert.-butylhydroperoxide 
• 106-43-4 para-chlorotoluene 
• 59305-51-0 1-chloro-4-<(phenylseleno)methyl>benzene 
• 35730-03-1 1-(4-chlorophenyl)-3-phenyl-2-propanone 
• 94887-77-1 1,1'-Diethyl-2,4,6,2',4',6'-hexamethyl-1,4,1',4'-tetrahydro-[4,4']bipyridinyl 
• 15784-28-8 allyl 4-chlorobenzoate 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 71017-85-1 1-(4-chlorobenzyl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate 
• 123-54-6 acetylacetone 
• 98-58-8 4-bromobenzenesulfonyl chloride 

Downstream Products

• 74-11-3 para-chlorobenzoic acid 
• 939983-56-9 3,4-bis(4-chlorophenyl)-1,2,5-thiadiazole 1,1-dioxide 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 81540-32-1 4,5-di-(4-chlorophenyl)-2-(4-(4,5-di(4-chlorophenyl)-1H-imidazol-2-yl)phenyl)-1H-imidazole 
• 24012-41-7 5-Phenyl-2,3,4-tris-(p-chlor-phenyl)-(αββ')-cyclopentadien-(2,4)-on-(1) 

Relevant articles and documents

Synthesis of Dibenzyls by Nickel-Catalyzed Homocoupling of Benzyl Alcohols

Dibenzyls are essential building blocks that are widely used in organic synthesis, and they are typically prepared by the homocoupling of halides, organometallics, and ethers. Herein, we report an approach to this class of compounds using alcohols, which are more stable and readily available. The reaction proceeds via nickel-catalyzed and dimethyl oxalate assisted dynamic kinetic homocoupling of benzyl alcohols. Both primary and secondary alcohols are tolerated.

"bulky-Yet-Flexible" α-Diimine Palladium-Catalyzed Reductive Heck Cross-Coupling: Highly Anti-Markovnikov-Selective Hydroarylation of Alkene in Air

To pursue a highly regioselective and efficient reductive Heck reaction, a series of moisture-and air-stable α-diimine palladium precatalysts were rationally designed, readily synthesized, and fully characterized. The relationship between the structures of the palladium complexes and the catalytic properties was investigated. It was revealed that the"bulky-yet-flexible"palladium complexes allowed highly anti-Markovnikov-selective hydroarylation of alkenes with (hetero)aryl bromides under aerobic conditions. Further synthetic application of the present protocol could provide rapid and straightforward access to functional and biologically active molecules.

Method for preparation of bibenzyl compounds by photocatalytic one-step process

The invention relates to a brand new low-cost method for synthesis of bibenzyl compounds. The method adopts green and clean light energy as the reaction energy, and takes toluene or a toluene derivative as the raw material to prepare bibenzyl compounds under the catalysis of a solid photocatalyst. The method is carried out at room temperature, and can prepare bibenzyl compounds directly by illumination. The reaction process includes: mixing a toluene derivative, a catalyst and a solvent, then putting the mixture into a pressure-resistant quartz container (larger than 1MPa), and performing replacement with inert gas, conducting illumination stirring at room temperature, and carrying out reaction for 1 or more hour. At the end of the reaction, the catalyst can be easily separated from the reaction system and can be recycled repeatedly, the reaction product can be separated by crystallization, and the yield of bibenzyl compounds can reach 3.21g (g catalyst)h. The method can be used for direct preparation of 1, 2-diphenylethane and natural bibenzyl drugs.