66095-34-9

Basic information

• Product Name: Benzamide, N-(6-aminohexyl)-
• CAS NO: 66095-34-9
• Molecular Formula: C13H20N2O
• Molecular Weight: 220.315
• Mol File: 66095-34-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzamide, N-(6-aminohexyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(6-aminohexyl)-(66095-34-9)
• EPA Substance Registry System: Benzamide, N-(6-aminohexyl)-(66095-34-9)

Safety Data

• Hazardous Substances Data: 66095-34-9(Hazardous Substances Data)

Upstream product

• 93-58-3 benzoic acid methyl ester 
• 124-09-4 1,6-Hexanediamine 
• 65-85-0 benzoic acid 
• 10364-94-0 1-benzoylimidazole 
• 6055-52-3 hexane-1,6-diamine dihydrochloride 
• 23405-15-4 benzoic acid N-hydroxysuccinimide ester 
• 55-21-0 benzamide 
• 98-88-4 benzoyl chloride 
• 51857-17-1 tert-butyl N-(6-aminohexyl)carbamate 

Downstream Products

• 40299-04-5 N-(2,4-dinitro-phenyl)-hexanediyldiamine 
• 313350-20-8 N₁-{6-[(3-nitroquinolin-4-yl)amino]hexyl}benzamide 
• 1603827-85-5 C₃₄H₄₇N₃O₁₀ 
• 1603827-86-6 C₃₀H₃₉N₃O₁₀ 
• 1674370-85-4 C₃₃H₄₅N₃O₁₀ 
• 1604244-23-6 C₃₃H₄₅N₃O₁₃S 
• 1603827-80-0 C₂₄H₃₁N₃O₄ 
• 1603827-81-1 C₂₇H₃₇N₃O₄ 
• 1603827-82-2 C₃₇H₄₇N₃O₁₃ 
• 1603827-83-3 C₄₀H₅₃N₃O₁₃ 
• 1603827-84-4 C₃₁H₄₁N₃O₁₀ 
• 313347-61-4 N₁-[6-(4-Amino-1H-imidazo[4,5-c]quinolin-1-yl)hexyl]benzamide 
• 313350-21-9 N₁-[6-(1H-imidazo[4,5-c]quinolin-1-yl)hexyl]benzamide 
• 1392320-96-5 C₄₀H₄₀N₄O₆ 

Relevant articles and documents

Improved reagents for newborn screening of mucopolysaccharidosis types I, II, and VI by tandem mass spectrometry

Tandem mass spectrometry for the multiplex and quantitative analysis of enzyme activities in dried blood spots on newborn screening cards has emerged as a powerful technique for early assessment of lysosomal storage diseases. Here we report the design and process-scale synthesis of substrates for the enzymes α-l-iduronidase, iduronate-2-sulfatase, and N-acetylgalactosamine-4- sulfatase that are used for newborn screening of mucopolysaccharidosis types I, II, and VI. The products contain a bisamide unit that is hypothesized to readily protonate in the gas phase, which improves detection sensitivity by tandem mass spectrometry. The products contain a benzoyl group, which provides a useful site for inexpensive deuteration, thus facilitating the preparation of internal standards for the accurate quantification of enzymatic products. Finally, the reagents are designed with ease of synthesis in mind, thus permitting scale-up preparation to support worldwide newborn screening of lysosomal storage diseases. The new reagents provide the most sensitive assay for the three lysosomal enzymes reported to date as shown by their performance in reactions using dried blood spots as the enzyme source. Also, the ratio of assay signal to that measured in the absence of blood (background) is superior to all previously reported mucopolysaccharidosis types I, II, and VI assays.

Efficient and continuous monoacylation with superior selectivity of symmetrical diamines in microreactors

Efficient and continuous monoacylation of symmetrical diamines performed in microreactors yielded superior selectivity to that predicted by statistical considerations. It is highly valuable that the kinetically controlled product in high yields was achieved without any special catalyst at ambient temperature.

Imidazole-catalyzed monoacylation of symmetrical diamines

Figure Presented. An imidazole-catalyzed protocol for monoacylation of symmetrical diamines has been developed. The protocol gave selective monoacylation of aliphatic (cyclic and acyclic) primary and secondary diamines. In the reaction, imidazole acts as both catalyst and a leaving group. Different monoacylated piperazines and other diamines were synthesized at room temperature in an ethanol/water solvent system.