66095-34-9

Upstream product

• 124-09-4 1,6-Hexanediamine 
• 55-21-0 benzamide 
• 98-88-4 benzoyl chloride 
• 51857-17-1 tert-butyl N-(6-aminohexyl)carbamate 
• 10364-94-0 1-benzoylimidazole 
• 6055-52-3 hexane-1,6-diamine dihydrochloride 
• 23405-15-4 benzoic acid N-hydroxysuccinimide ester 
• 65-85-0 benzoic acid 
• 93-58-3 benzoic acid methyl ester 

Downstream Products

• 40299-04-5 N-(2,4-dinitro-phenyl)-hexanediyldiamine 
• 313350-20-8 N₁-{6-[(3-nitroquinolin-4-yl)amino]hexyl}benzamide 
• 1392320-96-5 C₄₀H₄₀N₄O₆ 
• 1603827-85-5 C₃₄H₄₇N₃O₁₀ 
• 1603827-86-6 C₃₀H₃₉N₃O₁₀ 
• 1674370-85-4 C₃₃H₄₅N₃O₁₀ 
• 1604244-23-6 C₃₃H₄₅N₃O₁₃S 
• 1603827-80-0 C₂₄H₃₁N₃O₄ 
• 1603827-81-1 C₂₇H₃₇N₃O₄ 
• 1603827-82-2 C₃₇H₄₇N₃O₁₃ 
• 1603827-83-3 C₄₀H₅₃N₃O₁₃ 
• 1603827-84-4 C₃₁H₄₁N₃O₁₀ 
• 313347-61-4 N₁-[6-(4-Amino-1H-imidazo[4,5-c]quinolin-1-yl)hexyl]benzamide 
• 313350-21-9 N₁-[6-(1H-imidazo[4,5-c]quinolin-1-yl)hexyl]benzamide 

Relevant academic research and scientific papers

Improved reagents for newborn screening of mucopolysaccharidosis types I, II, and VI by tandem mass spectrometry

Tandem mass spectrometry for the multiplex and quantitative analysis of enzyme activities in dried blood spots on newborn screening cards has emerged as a powerful technique for early assessment of lysosomal storage diseases. Here we report the design and process-scale synthesis of substrates for the enzymes α-l-iduronidase, iduronate-2-sulfatase, and N-acetylgalactosamine-4- sulfatase that are used for newborn screening of mucopolysaccharidosis types I, II, and VI. The products contain a bisamide unit that is hypothesized to readily protonate in the gas phase, which improves detection sensitivity by tandem mass spectrometry. The products contain a benzoyl group, which provides a useful site for inexpensive deuteration, thus facilitating the preparation of internal standards for the accurate quantification of enzymatic products. Finally, the reagents are designed with ease of synthesis in mind, thus permitting scale-up preparation to support worldwide newborn screening of lysosomal storage diseases. The new reagents provide the most sensitive assay for the three lysosomal enzymes reported to date as shown by their performance in reactions using dried blood spots as the enzyme source. Also, the ratio of assay signal to that measured in the absence of blood (background) is superior to all previously reported mucopolysaccharidosis types I, II, and VI assays.

CDI-mediated monoacylation of symmetrical diamines and selective acylation of primary amines of unsymmetrical diamines

A highly efficient and green protocol for monoacylation of symmetrical diamines and chemoselective acylation of primary amines of unsymmetrical diamines has been developed.

Efficient and continuous monoacylation with superior selectivity of symmetrical diamines in microreactors

Efficient and continuous monoacylation of symmetrical diamines performed in microreactors yielded superior selectivity to that predicted by statistical considerations. It is highly valuable that the kinetically controlled product in high yields was achieved without any special catalyst at ambient temperature.

Structural analysis of ATP analogues compatible with kinase-catalyzed labeling

Kinase-catalyzed protein phosphorylation is an important biochemical process involved in cellular functions. We recently discovered that kinases promiscuously accept γ-modified ATP analogues as cosubstrates and used several ATP analogues as tools for stud

Imidazole-catalyzed monoacylation of symmetrical diamines

Figure Presented. An imidazole-catalyzed protocol for monoacylation of symmetrical diamines has been developed. The protocol gave selective monoacylation of aliphatic (cyclic and acyclic) primary and secondary diamines. In the reaction, imidazole acts as both catalyst and a leaving group. Different monoacylated piperazines and other diamines were synthesized at room temperature in an ethanol/water solvent system.

COMPOSITIONS AND METHODS FOR DETECTION OF LYSOSOMAL STORAGE DISEASE

The present invention provides compositions for performing assays of enzyme activity associated with lysosomal storage diseases. The invention further provides methods for determining enzyme activity, and methods for the screening for lysosomal storage disease in an individual.

Amide substituted imidazoquinolines

Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Amide substituted imidazoquinolines

Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Selective Monoacylation of Symmetrical Diamines via Prior Complexation with Boron

(Equation presented) Pretreatment of a symmetrical primary or secondary diamine with 9-BBN prior to the addition of an acyl chloride significantly suppressed undesired diacylation, and the product of monoacylation predominated. The reactive preference is interpreted as the result of a selective deactivation of one nitrogen atom of the diamine by 9-BBN.

The use of cellulose (chromatography paper) as a cheap, versatile and non-covalent support for organic molecules during multi-step synthesis

Cellulose chromatography paper provides a novel non-covalent support for synthesis and in-situ purification of multi-dimensional arrays.