66122-45-0

Upstream product

• 1079-72-7 6-(4-methylphenyl)-4,5-dihydro-3(2H)-pyridazinone 
• 123-11-5 4-methoxy-benzaldehyde 
• 108-88-3 toluene 
• 4619-20-9 3-(4-methylbenzoyl)propionic acid 
• 101537-01-3 C₁₉H₁₆O₃ 

Downstream Products

• 1444311-53-8 2-[5-(4-methoxybenzyl)-6-oxo-3-(p-tolyl)pyridazin-1(6H)-yl]acetic acid 
• 213681-73-3 4-(4-methoxybenzoyl)-6-p-tolylpyridazine-3(2H)one 

Relevant academic research and scientific papers

Further studies on 2-arylacetamide pyridazin-3(2H)-ones: Design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists

Formyl peptide receptors (FPRs) play an essential role in the regulation of endogenous inflammation and immunity. In the present studies, a large series of pyridazin-3(2H)-one derivatives bearing an arylacetamide chain at position 2 was synthesized and te

Synthesis and antitubercular activity of pyridazinone derivatives

Two series of pyridazinone derivatives (19-34) were synthesized and evaluated for antitubercular activities against Mycobacterium tuberculosis H37Rv strain. The results illustrated that among the synthesized compounds, compound 25, 5-(4-hydroxy-3-methoxybenzyl)-3-(4-chloro-phenyl)-1,6-dihydro-6-pyridazinone emerged as a lead compound with good antitubercular activity. Four more compounds, (21, 22, 29 & 33) were significant in their antitubercular action.

Synthesis and biological evaluation of some new pyridazinone derivatives

A series of pyridazinone derivatives (1934) were synthesized with an aim to synthesize safer anti-inflammatory agents. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation (LPO) actions. The percentage inhibition in edema at different time intervals indicated that compounds 20, 26, 28 and 34 exhibited good anti-inflammatory potential, comparable with that of ibuprofen (85.77%) within a range of 67.4877.23%. The results illustrate that 5-(4-fluoro-benzyl)-3-(4-chloro-phenyl) -1,6-dihydro-6-pyridazinone (26) and 5-(4-chloro-benzyl)-3-(4-chloro-phenyl)-1, 6-dihydro-6-pyridazinone (20) showed best anti-inflammatory activity. Furthermore, activity is more in case of chloro substitution as compared with methyl-substitution. The compounds synthesized were also evaluated for their ulcerogenic and LPO action and showed superior gastrointestinal safety profile along with reduction in LPO as compared with that of the ibuprofen.