66166-25-4Relevant academic research and scientific papers
Synthesis and Application of Heterocyclic Germatranes via Rhodium-Catalyzed Directed C?H Activation/Annulation with Alkynyl Germatranes and Palladium-Catalyzed Cross-Coupling
Xu, Meng-Yu,Wang, Chao,Jiang, Wei-Tao,Xiao, Bin
, p. 1706 - 1711 (2020)
Rhodium-catalyzed C?H activation and annulation with alkynyl germatranes for the synthesis of heterocyclic germatranes is described. Various heterocyclic germatranes were constructed by this protocol and applied in multiple derivatizations such as palladi
Synthesis of polysubstituted isoquinolines through cross-coupling reactions with α-alkoxytosylhydrazones
Florentino, Lucia,Aznar, Fernando,Valdes, Carlos
, p. 2323 - 2325 (2012/06/18)
A Pd-catalyzed cross-coupling reaction of α-alkoxytosylhydrazones with sulfonates derived from salicyl aldehydes gives rise to protected 1,5-dicarbonyl compounds. Treatment with ammonium hydroxide readily transforms these alkenes into isoquinolines with d
New synthesis of isoquinoline and 3,4-dihydroisoquinoline derivatives
Kobayashi, Kazuhiro,Shiokawa, Taiyo,Omote, Hiroki,Hashimoto, Kenichi,Morikawa, Osamu,Konishi, Hisatoshi
, p. 1126 - 1132 (2007/10/03)
A simple and efficient synthesis of isoquinoline and 3,4- dihydroisoquinoline derivatives is described. 1-Alkyl-(or aryl)isoquinoline and 1-isoquinolinamine derivatives were obtained by intramolecular cyclization of 2-(2-methoxyethenyl) benzonitriles initiated by the addition of alkyl(or aryl)lithiums and lithium dialkylamides to the nitrile carbons, respectively. Synthesis of 4-aryl-3,4-dihydroisoquinolines was achieved by reactions of 2-(1-arylethenyl)benzonitriles with organolithiums, followed by aqueous workup. Treatment of the reaction mixtures with electrophiles prior to aqueous workup allowed the synthesis of 4,4-disubstituted 3,4-dihydroisoquinolines.
A convenient synthesis of 1,4-disubstituted isoquinolines by reactions of α-substituted 2-lithio-β-methoxystyrenes with nitriles
Kobayashi, Kazuhiro,Hayashi, Kazutaka,Miyamoto, Kazuna,Morikawa, Osamu,Konishi, Hisatoshi
, p. 2934 - 2938 (2008/02/05)
It has been found that halogen-lithium exchange between α-substituted 2-bromo-β-methoxystyrene derivatives and n-butyllithium generates α-substituted 2-lithio-β-methoxystyrene derivatives, which successfully react with a range of nitriles to afford the co
New synthesis of isoquinoline derivatives by reactions of 2-(2-methoxyethenyl)benzonitriles with organolithiums and lithium dialkylamides
Kobayashi, Kazuhiro,Shiokawa, Taiyo,Morikawa, Osamu,Konishi, Hisatoshi
, p. 236 - 237 (2007/10/03)
A simple and efficient synthesis of 1-alkyl(or aryl)isoquinoline and isoquinolin-1-amine derivatives based on intramolecular cyclization of 2-(2-methoxyethenyl)benzonitriles initiated by the addition of alkyl(or aryl)lithiums and lithium dialkylamides to the nitrile carbons, respectively, is described.
SYNTHESIS OF 5,6,7,8-TETRAHYDRO-3-ISO-QUINOLYLAMINES
Hazai, Laszlo,Deak, Gyula,Toth, Gabor
, p. 601 - 605 (2007/10/02)
Reactions with dichlorophenylphosphine oxide of variously substituted 5,6,7,8-tetrahydro-3(2H)-isoquinolinones (1), synthesized formerly in this laboratory, gave the corresponding 3-chloro derivatives (2a - e), reactions of the latter compounds with ammonia furnished the 5,6,7,8-tetrahydro-3-isoquinolylamines, 3a - c, e.
A Reinvestigation of the Pictet-Gams Isoquinoline Synthesis. Part 2. Formation of Rearranged Isoquinolines: the Δ2-Oxazoline-Isoquinoline Transformation
Ardabilchi, Nasser,Fitton, Alan O.,Hadi, A. Hamid b. A.,Thompson, J. Robin
, p. 1710 - 1725 (2007/10/02)
Cyclisation of a series of 2-substituted 2-acylamino-1-arylalkan-1-ols using phosphorus pentaoxide in refluxing decalin is shown to lead to rearranged, i.e. 4-substituted, isoquinolines in addition to the anticipated 3-substituted isomers.The products arise largely via 5-phenyl-Δ2-oxazoline intermediates and the formation of the rearranged isoquionolines from these intermediates is fully discussed.The pathway is not substantially altered when 2-benzamido-1-methoxy-1-phenylalkanes are cyclised.
PREPARATION OF 1,4-DIPHENYL-3-SUBSTITUTED ISOQUINOLINES
Mataka, Shuntaro,Takahashi, Kazufumi,Tsuda, Yuhsuke,Tashiro, Masashi
, p. 789 - 792 (2007/10/02)
The reaction of o-dibenzoylbenzene (1) with benzylamine (2a), m-(2b) and p-xylylendiamine (2c), n-butylamine (2d), ethylglycinate (2f) and aminoacetonitrile (2g) in the presence of basic catalysts afforded the corresponding 3-substituted 1,4-diphenylisoquinolines (3a-d, f, g, and i), while the reaction of 1 with ethanolamine (2e) gave a trace amount of 3-hydroxymethylisoquinoline (3e) and 1,3-diphenylisobenzofuran (4) in 25percent yield.
