75097-30-2Relevant academic research and scientific papers
One-step synthesis of 1,4-bis(het)arylisoquinolines by the reaction of 1,2,4-triazines with arynes
Kopchuk, Dmitry S.,Nikonov, Igor L.,Khasanov, Albert F.,Gundala, Sravya,Krinochkin, Alexey P.,Slepukhin, Pavel А.,Zyryanov, Grigory V.,Venkatapuram, Padmavathi,Chupakhin, Oleg N.,Charushin, Valery N.
, p. 978 - 984 (2019)
[Figure not available: see fulltext.] The reaction of 3,6-bis(het)aryl-1,2,4-triazines (hetaryl ≠ 2-pyridyl) with aryne intermediates generated in situ was studied. As a result, novel 1,4-bis(het)arylisoquinolines were synthesized with yields of up to 45%. The main rules of the reactions were studied, and the obtained experimental data were compared with those described in the literature.
PREPARATION OF 1,4-DIPHENYL-3-SUBSTITUTED ISOQUINOLINES
Mataka, Shuntaro,Takahashi, Kazufumi,Tsuda, Yuhsuke,Tashiro, Masashi
, p. 789 - 792 (2007/10/02)
The reaction of o-dibenzoylbenzene (1) with benzylamine (2a), m-(2b) and p-xylylendiamine (2c), n-butylamine (2d), ethylglycinate (2f) and aminoacetonitrile (2g) in the presence of basic catalysts afforded the corresponding 3-substituted 1,4-diphenylisoquinolines (3a-d, f, g, and i), while the reaction of 1 with ethanolamine (2e) gave a trace amount of 3-hydroxymethylisoquinoline (3e) and 1,3-diphenylisobenzofuran (4) in 25percent yield.
