66190-31-6Relevant articles and documents
Experimental investigations of a partial Ru-O bond during the metal-ligand bifunctional addition in noyori-type enantioselective ketone hydrogenation
Takebayashi, Satoshi,Dabral, Nupur,Miskolzie, Mark,Bergens, Steven H.
, p. 9666 - 9669 (2011)
The transition state for the metal-ligand bifunctional addition step in Noyori's enantioselective ketone hydrogenation was investigated using intramolecular trapping experiments. The bifunctional addition between the Ru dihydride trans-[Ru((R)-BINAP)(H)2((R,R)-dpen)] and the hydroxy ketone 4-HOCH2C6H4(CO)CH3 at -80 °C exclusively formed the corresponding secondary ruthenium alkoxide trans-[Ru((R)-BINAP)(H)(4-HOCH2C6H4CH(CH 3)O)((R,R)-dpen)]. Combined with the results of control experiments, this observation provides strong evidence for the formation of a partial Ru-O bond in the transition state.