14490-45-0

Basic information

• Product Name: Benzaldehyde, 4-(2-methyl-1,3-dioxolan-2-yl)-
• Synonyms: 4'-formylacetophenone ethylene acetal
• CAS NO: 14490-45-0
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Mol File: 14490-45-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-(2-methyl-1,3-dioxolan-2-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-(2-methyl-1,3-dioxolan-2-yl)-(14490-45-0)
• EPA Substance Registry System: Benzaldehyde, 4-(2-methyl-1,3-dioxolan-2-yl)-(14490-45-0)

Safety Data

• Hazardous Substances Data: 14490-45-0(Hazardous Substances Data)

Usage

Uses

4-(2-Methyl-1,3-dioxolan-2-yl)benzaldehyde is an intermediate in the synthesis of 1-(4-(1-Hydroperoxy-2-methyl)propyl)phenyl)ethan-1-one (H354985). It is useful in many synthetic preparations.

Upstream product

• 764-48-7 ethyleneglycol vinyl ether 
• 1122-91-4 4-bromo-benzaldehyde 
• 109-72-8 n-butyllithium 
• 4360-68-3 2-(4-bromophenyl)-2-methyl-1,3-dioxolane 
• 3609-53-8 methyl 4-acetylbenzoate 
• 78906-12-4 2-methyl-2-(4-hydoxymethylphenyl)-1,3-dioxolyn 
• 78906-11-3 2-methyl-2-(4-methoxycarbonylphenyl)-1,3-dioxolan 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 214701-35-6 2-(4-iodophenyl)-2-methyl-[1,2]-dioxolane 
• 99-90-1 para-bromoacetophenone 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 105752-35-0 1-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)ethanone 
• 78906-12-4 2-methyl-2-(4-hydoxymethylphenyl)-1,3-dioxolyn 
• 75633-63-5 4-(hydroxymethyl)acetophenone 
• 22072-50-0 1-(4-(methoxymethyl)phenyl)ethanone 
• 66190-31-6 (+)-1-(4-methoxymethylphenyl)ethanol 
• 66190-31-6 (-)-1-(4-methoxymethylphenyl)ethanol 
• 1312214-65-5 (-)-1-(4-hydroxymethylphenyl)ethanol 
• 81223-80-5 dithiolanne du (methyl-4' benzenesulfonyl)-1 acetyl-6 indole 
• 81223-79-2 dioxolanne du (methyl-4' benzenesulfonyl)-1 acetyl-6 indole 
• 81223-77-0 (methyl-4' benzenesulfonyl)-1 de l'acetyl-6 indole 
• 81223-83-8 acide cinnamoyl-6 indolecarboxylique-2 
• 81223-75-8 dioxolanne de l'acetyl-6 indole 
• 81223-95-2 acide acetyl-6 indoleacetique-3 
• 81223-84-9 (indolyl-6')-1 propene-2 phenyl-3 one-1 

Relevant articles and documents

POLYCYCLIC AMINES AS OPIOID RECEPTOR MODULATORS

The present invention provides a genus of polycyclic amines that are useful as opioid receptor modulators. The compounds of the invention are useful in both therapeutic and diagnostic methods, including for treating pain, neurological disorders, cardiac disorders, bowel disorders, drug and alcohol addiction, drug overdose, urinary disorders, respiratory disorders, sexual dysfunction, psoriasis, graft rejection or cancer.

Reductive carbonylation of aryl halides employing a two-chamber reactor: A protocol for the synthesis of aryl aldehydes including 13C- and D-isotope labeling

A protocol has been developed for conducting the palladium-catalyzed reductive carbonylation of aryl iodides and bromides using 9-methylfluorene-9- carbonyl chloride (COgen) as a source of externally delivered carbon monoxide in a sealed two-chamber system (COware), and potassium formate as the in situ hydride source. The method is tolerant to a wide number of functional groups positioned on the aromatic ring, and it can be exploited for the isotope labeling of the aldehyde group. Hence, reductive carbonylations run with 13COgen provide a facile access to 13C-labeled aromatic aldehydes, whereas with DCO2K, the aldehyde is specifically labeled with deuterium. Two examples of double isotopic labeling are also demonstrated. Finally, the method was applied to the specific carbon-13 labeling of the β-amyloid binding compound, florbetaben.

Palladium-catalysed direct regioselective synthesis of cyclic ketals from electron-rich olefins and aryl bromides in ionic liquids

The Heck reaction comprises one of the most important carbon-carbon coupling reactions in organic synthesis. The popularity of the reaction is attributable to the broad availability of aryl halides and to the tolerance of the reaction for a wide variety o