6621-60-9 Usage
Chemical class
Urea derivative
Appearance
White, crystalline solid
Solubility
Soluble in organic solvents
Uses
Reagent in organic synthesis
Intermediate in the production of pharmaceuticals and agricultural chemicals
Manufacturing of polymers and resins
Applications in medicinal chemistry
Potential applications in drug discovery
Molecular interactions
Ability to form hydrogen bonds
Biological processes
Useful in certain types of molecular interactions and biological processes due to hydrogen bonding capability
These properties and applications highlight the versatility and importance of 1,3-Di-(5-carbomethoxyamyl) urea in various fields, including organic synthesis, pharmaceuticals, agriculture, and medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 6621-60-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,2 and 1 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6621-60:
(6*6)+(5*6)+(4*2)+(3*1)+(2*6)+(1*0)=89
89 % 10 = 9
So 6621-60-9 is a valid CAS Registry Number.
InChI:InChI=1/C15H28N2O5/c1-21-13(18)9-5-3-7-11-16-15(20)17-12-8-4-6-10-14(19)22-2/h3-12H2,1-2H3,(H2,16,17,20)
6621-60-9Relevant academic research and scientific papers
Novel symmetrical ureas as modulators of protein arginine methyl transferases
Fontán, Noelia,García-Domínguez, Patricia,álvarez, Rosana,De Lera, ángel R.
supporting information, p. 2056 - 2067 (2013/05/09)
Methylation of histone arginine residues is an epigenetic mark related to gene expression that is implicated in a variety of biological processes and can be reversed by small-molecule modulators of protein arginine methyltransferases (PRMTs). A series of symmetrical ureas, designed as analogues of the known PRMT1 inhibitor AMI-1 have been synthesized using Pd-catalyzed Ar-N amide bond formation processes or carbonylation reactions as key steps. Their inhibitory profile has been characterized. The enzymatic assays showed a weak effect on PRMT1 and PRMT5 activity for most of the compounds. The acyclic urea that exhibited the strongest effect on the inhibition of the PRMT1 activity also showed the greatest effect on the expression of some androgen receptor target genes (TMPRSS2 and FKBP5), which may be related with its enzymatic activity. Surprisingly, AMI-1 behaved as an activator of PRMT5 activity, a result not reported so far.
