66240-21-9

Usage

Uses

Used in Organic Synthesis:
1-Iodo-7-methoxynaphthalene is used as a reagent for the introduction of the iodo group into other molecules, facilitating the synthesis of a wide range of organic compounds.
Used in Pharmaceutical Industry:
1-Iodo-7-methoxynaphthalene is used as a building block in the creation of pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
1-Iodo-7-methoxynaphthalene is used in the development of agrochemicals, playing a role in the synthesis of compounds with pesticidal or herbicidal properties.
Used in Biological Activity Research:
1-Iodo-7-methoxynaphthalene is studied for its potential as an antioxidant and anti-inflammatory agent, indicating its possible use in the development of treatments for various diseases and conditions.
Used in Material Science:
1-Iodo-7-methoxynaphthalene is investigated for its potential use in the development of new materials, suggesting its application in creating innovative products with unique properties.

Upstream product

• 5302-79-4 7-methoxynaphthalen-1-amine 
• 118-46-7 8-amino-2-naphthol 
• 29921-51-5 1-iodo-7-hydroxynaphthalene 
• 77-78-1 dimethyl sulfate 
• 6470-18-4 1-acetylamino-7-naphthol 
• 93189-18-5 N-(7-methoxynaphthalen-1-yl)acetamide 

Downstream Products

• 158365-54-9 1-cyano-7-methoxynaphthalene 
• 158365-55-0 7-methoxynaphthalene-1-carbaldehyde 
• 138113-09-4 2-(7-methoxynaphth-1-yl)ethylamine 
• 138112-76-2 agomelatine 

Relevant academic research and scientific papers

An Unprecedented, Lewis Acid-Mediated, Metal-Free Iodoannulation Strategy to Aromatic Iodides

A direct transformation of ortho-alkynylated aromatic vinyl ethers to 1-iodonaphthalenes and other iodo-heterocycles under mild Lewis acidic conditions in the presence of iodide as an external nucleophile is reported. The first example of an iodoannulation strategy using a nucleophilic source of iodine, coupled with good to excellent yields, exclusive alpha regioselectivity and a broad substrate scope makes this work an attractive avenue towards the construction of aromatic iodides.

Synthesis method of Agomelatine

The invention relates to a preparation method of Agomelatine. The preparation method is characterized by comprising the following steps: halogenating 7-methoxy-naphthylamine, performing potassium vinyltrifluoroborate substituting and ammonifying and protecting acetyl, so as to obtain a product. The preparation method has the advantages of being easily available in raw materials, concise in processes, high in total yield, less in by-products and simple in aftertreatment, therefore, the preparation method is suitable for industrial production.

A facile synthesis of melatonergic antidepressant agomelatine

Agomelatine was synthesized from 8-aminonaphthalen-2-ol by diazotization-iodination, formylation, C-C bond formation by nitroaldol and Pd/C hydrogenation of β-nitrovinylnaphthalene followed by N-acetylation. The route reported employs readily and commercially viable starting materials and reagents, and can potentially be utilized for process synthesis of agomelatine.