6628-28-0

Basic information

• Product Name: 2-METHYL-6-ETHOXYQUINOLINE
• Synonyms: 6-ETHOXY-2-METHYLQUINOLINE;6-ETHOXYQUINALDINE;2-METHYL-6-ETHOXYQUINOLINE;6-ethoxy-2-methyl-quinolin;Quinaldine, 6-ethoxy-;Quinoline, 6-ethoxy-2-methyl-;Einecs 229-609-1;Nsc 60562
• CAS NO: 6628-28-0
• Molecular Formula: C₁₂H₁₃NO
• Molecular Weight: 187.24
• EINECS: 229-609-1
• Product Categories: Alkoxyquinolines;Alkylquinolines;Quinolines
• Mol File: 6628-28-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 70°C
• Boiling Point: 301.3 °C at 760 mmHg
• Flash Point: 110.5 °C
• Appearance: /
• Density: 1.078 g/cm³
• Refractive Index: 1.633
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 5.90±0.43(Predicted)
• CAS DataBase Reference: 2-METHYL-6-ETHOXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-6-ETHOXYQUINOLINE(6628-28-0)
• EPA Substance Registry System: 2-METHYL-6-ETHOXYQUINOLINE(6628-28-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 6628-28-0(Hazardous Substances Data)

Usage

General Description

2-Methyl-6-ethoxyquinoline is a chemical compound with the molecular formula C12H13NO. It is a yellow crystalline solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-Methyl-6-ethoxyquinoline is known for its potent antimicrobial and antifungal properties, making it a popular ingredient in various industrial and commercial applications. It is also used as a corrosion inhibitor in metalworking fluids and as a fragrance in the production of perfumes and personal care products. Additionally, it has been studied for its potential anti-inflammatory and antioxidant properties, making it a subject of interest in the field of medicinal chemistry.

InChI:InChI=1/C28H21Cl2N3O5/c1-37-25-13-17(9-12-24(25)38-28(36)19-10-11-22(29)23(30)14-19)15-32-33-26(34)16-31-27(35)21-8-4-6-18-5-2-3-7-20(18)21/h2-15H,16H2,1H3,(H,31,35)(H,33,34)

Upstream product

• 61587-14-2 N-(4-ethoxyphenyl)formamide 
• 123-63-7 paracetaldehyde 
• 156-43-4 4-Ethoxyaniline 
• 75-00-3 chloroethane 
• 75-03-6 ethyl iodide 
• 64-17-5 ethanol 
• 613-21-8 6-hydroxyquinaldine 
• 123-73-9 crotonaldehyde 
• 75-07-0 acetaldehyde 

Downstream Products

• 74839-93-3 4-[trans-2-(6-ethoxy-[2]quinolyl)-vinyl]-N,N-dimethyl-aniline 
• 60090-54-2 6-ethoxy-1-methyl-2-(3-nitro-trans-styryl)-quinolinium; toluene-4-sulfonate 
• 68516-69-8 6-ethoxy-1,2-dimethyl-quinolinium; methyl sulfate 
• 100063-12-5 6-ethoxyquinoline-2-carbaldehyde 
• 104116-70-3 6-ethoxy-quinoline-2-carboxylic acid 

Relevant articles and documents

Electrophilic addition of alcohols to 1-vinyl-2-phenylazopyrroles and unexpected formation of 2-methylquinoline

1-Vinyl-2-phenylazopyrroles react with alcohols in the presence of acids or PdCl2 to give 1-(1-alkoxyethyl)-2-phenylazopyrroles in up to 49% yield. In the presence of trifluoroacetic acid 2-methylquinoline unexpectedly formed (yield up to 26%) involving into the reaction the phenylazo and 1-vinyl groups.

Facile synthesis of 2-methylquinolines from anilines on mesoporous N-doped TiO2 under UV and visible light

Nitrogen-doped TiO2 was synthesized by a simple wet method using a nitrogen precursor hydrazine hydrate and nano TiO2. This photocatalyst was characterized by X-ray diffraction, highresolution transmission electron microscopy, diffused reflectance spectra, photoluminescence, and X-ray photoelectron spectroscopy. XPS analysis indicates the incorporation of anionic nitrogen in TiO2 lattice as O-Ti-N linkage. N2 adsorption-desorpion isotherm indicates the mesoporous nature of N-TiO2 with the surface area 130.0 m2/g. Sizes of N-TiO2 particles are found to be in the range of 5-30 nm by HRTEM images. DRS spectra reveal the extended absorption to the visible range. N-TiO2 is found to be more efficient than Ag-TiO2, Au-TiO2, and Pt-TiO2 in quinaldine synthesis under visible light. Copyright Taylor & Francis Group, LLC.

Au-doped TiO2 nanoparticles for selective photocatalytic synthesis of quinaldines from anilines in ethanol

A convenient eco-friendly photocatalytic synthesis of quinaldines has been developed by a simple one-pot reaction of anilines in ethanol solution with Au-loaded TiO2 under UV irradiation. Upon irradiation in the presence of Au-TiO2, aniline and oxidation products derived from ethanol undergo condensation-cyclization to afford quinaldines.