6628-41-7

Usage

Molecular weight

194.19 g/mol

Chemical structure

2-(4-hydroxyphenyl)-3-phenylprop-2-enoic acid

Occurrence

Found in the cell walls of plants such as fruits, vegetables, and grains

Antioxidant properties

Potent antioxidant

Biological activities

Anti-inflammatory, anti-cancer, and neuroprotective properties

Skin health benefits

Anti-aging and photoprotective effects, used in skincare products

Cardiovascular health

Potential benefits in improving cardiovascular health

Oxidative stress protection

Investigated for its role in protecting against oxidative stress

Potential applications

Promising potential in various fields of medicine and wellness.

Upstream product

• 156-38-7 4-hydroxyphenylacetate 
• 851318-56-4 2-(4-allyloxyphenyl)-3-phenylacrylic acid allyl ester 
• 100-52-7 benzaldehyde 
• 55784-07-1 4-hydroxyphenylacetic acid isopropyl ether 

Downstream Products

• 3839-46-1 (Z)-1-(4-hydroxyphenyl)-2-phenylethene 
• 1228768-06-6 C₂₈H₂₃NO₅S 
• 1228768-05-5 C₂₇H₂₁NO₅S 
• 1228768-04-4 C₂₆H₁₉NO₅S 
• 1228767-74-5 C₂₈H₂₅NO₅S 
• 1228767-72-3 C₂₇H₂₃NO₅S 
• 1228767-70-1 C₂₆H₂₁NO₅S 
• 887572-09-0 C₁₆H₁₄O₃ 
• 869722-54-3 2-(4-hydroxy-phenyl)-3-phenyl-propionic acid 
• 1361305-13-6 C₁₅H₁₄O₃ 

Relevant academic research and scientific papers

Synthesis and insect antifeedant activity of stilbene derivatives against Brontispa longissima Larvae

Continuing our search for natural product-based compounds for the control of B. longissima Larvae, 25 stilbene analogs were synthesized and evaluated for insect antifeedant activity against third-instar larvae of B. longissima for the first time. Among all the tested compounds, especially compounds 3a, 3c, and 6 showed pronounced antifeedant activities with AFC50 values of 0.218, 0.327, and 0.226 mg/mL, respectively. The different antifeedant activity ranges of these compounds indicated that variation of chemical structures in the stilbene skeleton markedly affected the activity profiles of this compound class, and some important SAR information has been revealed from it. In addition, to understand the structural requirements for antifeedant activities of the 25 synthesized stilbene analogs, a comparative molecular field analysis (CoMFA) model, which yielded the leave-one-out (LOO) cross-validated correlation coefficient (q 2) of 0.533 and a non-cross-validated correlation coefficient (r 2) of 0.929, was constructed. Together, these preliminary results may be useful in guiding further modification of stilbenes in the development of potential new antifeedants.

3-Aryl-2-{4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxy]-phenyl}-acrylic acid alkyl ester: Synthesis and antihyperglycemic evaluation

A number of 2,4-thiazolidinedione derivatives of aryl-substituted cinnamic acid were synthesized and studied for their antihyperglycemic activity in neonatal streptozotocin- induced diabeticWistermale rats. Substitution of the aryl ring resulted in higher activity. 3-(2,4-Dimethoxyphenyl)- 2-{4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxy]-phenyl}- acrylic acid methyl ester (Thz7), was found to be most active compound in this series which showed that disubstitutions on aryl ring by electron releasing groups were found suitable for promising antihyperglycemic activity. Increase in the ester carbon chain length decreased the activity.

DEVELOPMENT OF NEW SELECTIVE ESTROGEN RECEPTOR MODULATORS

The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs

A re-investigation of resveratrol synthesis by Perkins reaction. Application to the synthesis of aryl cinnamic acids

A re-investigation of resveratrol synthesis by Perkins reaction allowed to improve this method and to determine the configuration of the intermediates. The results were applied to the synthesis of several aryl cinnamic acids for biological evaluation.