6629-80-7Relevant academic research and scientific papers
Synthetic method of 5-N,N-dibenzylamine acetyl salicylamide
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Paragraph 0027-0028, (2019/03/08)
The invention discloses a synthetic method of 5-N,N-dibenzylamine acetyl salicylamide. The synthetic method comprises the steps of protecting salicylamide with aldehyde, ketone or acetal and ketal with different substituents, reacting with an alpha-halogenated acylation reagent so as to obtain an intermediate II, substituting halogen atoms with dibenzylamine, and finally carrying out acidificationdeprotection, so as to obtain 5-N,N-dibenzylamine acetyl salicylamide. The synthetic method provided by the invention has the characteristics of high yield, few impurities, low cost, easiness in amplification and the like.
Synthesis and anticonvulsant activity evaluation of 2-Phenyl-2H-benzo[e][1, 3]oxazin-4(3H)-ones
Cui, Li-Jing,Guo, Jun,Gong, Guo-Hua,Quan, Zhe-Shan
, p. 2553 - 2556 (2014/06/09)
A series of new 2-phenyl-2H-benzo[e][1,3]oxazin-4(3H)-one derivatives (1a-1t) were designed based on the known anticonvulsant activity of quinolinone derivatives. All target compounds 1a-1t, characterized by IR, 1H NMR and MS, have been evaluated for their anticonvulsant activity against MES-induced seizures. The pharmacological results showed that all the compounds displayed some degree of anticonvulsant activity. Among them, 2-phenyl-2,3-dihydrobenzo[e][1,3]oxazin-4-one (1a) and 2-(2-fluorophenyl)-2,3- dihydrobenzo-[e][1,3]oxazin-4- one (1b) were considerd more promising because of their lower ED50 (34.1 and 28.4 mg/kg) and higher protective index (11.1 and 8.0).
Reactions of 4-oxo-1,3-benzoxazinium perchlorates with sodium borohydride
Vikrishchuk,Ryabukhin,Vikrishchuk
experimental part, p. 1509 - 1512 (2009/12/04)
Reduction of 4-oxo-1,3-benzoxazinium perchlorates with sodium borohydride depending on the structure of starting salt and the reaction conditions leads to different products. 2-Alkyl- and 2-phenylsubstituted salts react with sodium borohydride to give 2,3
One-pot heterocondensation for benzoxazinone derivatives using sodium perborate as catalsyt
Kidwai, Mazaahir,Singhal, Priya,Singhal, Kavita
, p. 1615 - 1622 (2008/09/17)
An efficient synthesis of series of benzoxazinones, employing sodium perborate tetrahydrate (SPB) as a condensing agent is described. SPB in water and formic acid system is proved as a selective catalyst of hydration for cyanides. The rate enhancement and
Dual PPAR-α and -γ activators derived from novel benzoxazinone containing thiazolidinediones having antidiabetic and hypolipidemic potential
Madhavan, Gurram R.,Chakrabarti, Ranjan,Anantha Reddy,Rajesh,Balraju,Bheema Rao,Rajagopalan,Iqbal, Javed
, p. 584 - 591 (2007/10/03)
2,4-Thiazolidinedione derivatives of 1,3-benzoxazinone were synthesized and evaluated for their PPAR-α and -γ dual activation. DRF-2519, a compound obtained through SAR of TZD derivatives of benzoxazinone, has shown potent dual PPAR activation. In ob/ob mice, it showed better efficacy than the comparator molecules. In fat fed rat model, it showed significant improvement in lipid parameters, which was better than fibrates.
Novel compounds and their use as positive AMPA receptor modulators
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, (2008/06/13)
The invention provides novel compounds represented by the general formula 5 compound represented by the formula: wherein the bond represented by the broken line may be a single, a double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R2; X represents SO2 or C═O or CH2; Y represents —CH(R4)—, —N(R4)— or —N(R4)—CH2—, O; and the meaning of R2, R3, R4, R5, R6, R7, and R8 are as defined in the application The compounds are useful as positive modulators of the AMPA-receptor.
Dihydro benzoxazinones and benzoxazinediones' derivatives : thesis and study as bactericides and fungicides
Devaux,Renaudie,Boineau,et al.
, p. 44 - 50 (2007/10/04)
A series of 3,4 dihydro 2 H 1,3 benzoxazine 2,4 diones and 3,4 dihydro 2 H 1,3 benzoxazine 4 ones were synthesized from several salicylamides and salicylanilides. Their antibacterial and antifungal activities in vitro were studied on Staphylococcus aureus 209 P A.T.C.C. (6538 P), Pseudomonas aeruginosa I.P. C.C.E.B. 481, Escherichia coli K 12 C600 (λ-) and Candida albicans. Always negative on colibacillus, activity on Staphylococcus aureus seems to be conditioned by presence of halogeno or nitro substituents: one of the compounds is notably active. Transformation into the heterocyclic derivative generally lowers or cancels action on Candida albicans; conversely, it frequently provokes action on Bacillus pyocyaneus on which some monoketonic derivatives were quite effective.
