6631-42-1

Basic information

• Product Name: N-PHENYL-1,3-BENZOXAZOL-2-AMINE
• Synonyms: N-PHENYL-1,3-BENZOXAZOL-2-AMINE;N-PHENYLBENZO[D]OXAZOL-2-AMINE
• CAS NO: 6631-42-1
• Molecular Formula: C₁₃H₁₀N₂O
• Molecular Weight: 210.2313
• Mol File: 6631-42-1.mol
• Article Data: 40

Chemical Properties

• Boiling Point: 349.4°Cat760mmHg
• Flash Point: 165.1°C
• Appearance: /
• Density: 1.269g/cm³
• Vapor Pressure: 4.72E-05mmHg at 25°C
• Refractive Index: 1.697
• CAS DataBase Reference: N-PHENYL-1,3-BENZOXAZOL-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-PHENYL-1,3-BENZOXAZOL-2-AMINE(6631-42-1)
• EPA Substance Registry System: N-PHENYL-1,3-BENZOXAZOL-2-AMINE(6631-42-1)

Safety Data

• Hazardous Substances Data: 6631-42-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H10N2O/c1-2-6-10(7-3-1)14-13-15-11-8-4-5-9-12(11)16-13/h1-9H,(H,14,15)

Upstream product

• 17073-34-6 N-(2-hydroxyphenyl)-N'-phenylthiourea 
• 1520-26-9 2-hydroxyphenylthiourea 
• 62-53-3 aniline 
• 95-55-6 2-amino-phenol 
• 4955-82-2 1-cyanothioformanilide 
• 4426-68-0 phenyl isoselenocyanate 
• 701-73-5 methyl N-phenyldithiocarbamate 
• 273-53-0 benzoxazole 
• 587-65-5 N-chloroacetyl-aniline 
• 2382-96-9 2-sulfanyl-1,3-benzoxazole 
• 1056477-06-5 2-bromocyclohexanone 
• 64-10-8 phenyl carbamate 
• 108-94-1 cyclohexanone 
• 117-99-7 2-Hydroxybenzophenone 

Downstream Products

• 136540-09-5 2-N-methyl-N-phenylaminobenzoxazole 
• 78749-99-2 6-nitro-N-phenylbenzo[d]oxazol-2-amine 
• 56350-66-4 3-acetyl-2-anilino-2,3-dihydro-benzooxazole 

Relevant articles and documents

Environment-friendly and efficient synthesis of 2-aminobenzo-xazoles and 2-aminobenzothiazoles catalyzed by: Vitreoscilla hemoglobin incorporating a cobalt porphyrin cofactor

In this study, an environment-friendly and efficient artificial Vitreoscilla hemoglobin (VHb) for the synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles has been reported. We demonstrate an expression-based porphyrin substitution strategy to produce VHb containing cobalt porphyrin instead of native hemin, which can catalyze the oxidative cyclization of corresponding 2-aminobenzoxazoles and 2-aminobenthiazoles with up to 97% yield and 4850 catalytic turnovers in water under aerobic conditions. Hence, we provide a green and mild method for the synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles. In addition, we indicate the value of porphyrin ligand substitution as a strategy to tune and enhance the catalytic properties of hemoproteins in non-natural reactions.

Electrochemical NaI/NaCl-mediated one-pot synthesis of 2-aminobenzoxazoles in aqueous mediaviatandem addition-cyclization

An electrochemical synthesis of 2-aminobenzoxazoles from 2-aminophenols and isothiocyanates was successfully developed in a one-pot fashion. Using inexpensive and widely available NaI and NaCl co-operatively in catalytic amounts, our electrosynthesis approach provided various 2-aminobenzoxazole products in moderate to high yields in an open-flask type undivided cell without using any external supporting electrolyte and base. The protocol can be applied to the synthesis of 2-aminobenzothiazoles from the corresponding 2-thiophenols in moderate yields. This protocol has many benefits. It is metal-free and highly scalable and uses inexpensive mediators and EtOH/water as an environmentally friendly solvent under mild conditions.

A Cu2O/TBAB-promoted approach to synthesize heteroaromatic 2-Amines: Via one-pot cyclization of aryl isothiocyanates with ortho-substituted amines in water

An efficient approach to synthesize heteroaromatic 2-Amines from one-pot desulfurization/dehydrogenative cyclization of aryl isothiocyanates with ortho-substituted amines in water was developed. This approach tolerated a wide range of functional groups on