6632-12-8

Usage

1-Methyl-2,5-diphenyl-4-pyrazoline-3-one

A chemical compound, also known as DPPH.

Commonly used

In antioxidant assays.

Stable free radical molecule

With a purple color in its oxidized form.

Employed as a reagent

To measure the antioxidant capacity of various substances.

Widely used in food science and medicine

To evaluate the effectiveness of natural and synthetic antioxidants in inhibiting oxidative damage.

Ability to accept an electron

Makes it a valuable tool for assessing the radical-scavenging properties of different compounds.

Applications in environmental science

Used to evaluate the antioxidant potential of natural extracts and other samples.

InChI:InChI=1/C16H14N2O/c1-17-15(13-8-4-2-5-9-13)12-16(19)18(17)14-10-6-3-7-11-14/h2-12H,1H3

Upstream product

• 622-36-6 1-methyl-2-phenylhydrazine 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 74-88-4 methyl iodide 
• 539-44-6 N-4-methylphenylhydrazine 
• 6632-05-9 2,5-diphenyl-1,2-dihydro-pyrazol-3-one 
• 692283-15-1 C₁₆H₁₄N₂O 
• 100-63-0 phenylhydrazine 

Downstream Products

• 52744-73-7 4-amino-1-methyl-2,5-diphenylpyrazole-3-one 

Relevant academic research and scientific papers

PYRAZOLONE DERIVATIVE HAVING CYCLIC SIDE CHAIN

PROBLEM TO BE SOLVED: To provide a compound that has excellent inhibitory action on ATPase activity of TIP48/TIP49 complex and is therefore useful for the treatment of tumor, or a pharmacologically acceptable salt thereof. SOLUTION: The present invention provides a compound having a structure represented by general formula (I), its pharmacologically acceptable salt, or a pharmaceutical composition comprising the compound (where R1, R2, R3, R4, R5, R6, R7, W, and Z are as defined in the specifications). SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

An easy direct arylation of 5-pyrazolones

A mild, efficient and catalytic ligand-free method for the direct arylation of 5-pyrazolones by Pd-catalyzed C-H bond activation is reported. The process smoothly proceeds and yields are moderate to excellent.

Room-temperature direct alkenylation of 5-pyrazolones

A mild and efficient method for the direct alkenylation of 5-pyrazoles by Pd-catalyzed C-H bond activation is described. The reaction smoothly proceeds at room temperature to provide products in up to 92 % yield. Heterocycles containing the 5-pyrazolone moiety are synthesized by an oxidative Heck-type reaction. The direct alkenylation of 5-pyrazolones at room temperature through Pd-catalyzed C-H bond activation is described. Copyright

Mechanisms of Heterocycle Ring Formation. Part 5. A Carbon-13 Nuclear Magnetic Resonance Study of Pyrazolinone Synthesis by the Reaction of β-Ketoesters with Substituted Hydrazines

The 16 reactions between each of four hydrazines and four β-ketoesters have been followed by 13C n.m.r. spectroscopy.Peaks were assigned to starting materials, intermediates, and products, and reaction mechanisms determined and rationalized.Most rections proceed by attack of the least hindered hydrazine nitrogen atom on the keto carbon group of the ketoester.Relative rates of nucleophilic attack determine the build-up of intermediate and in some cases the nature of the products formed.