6632-37-7

Basic information

• Product Name: NSC57663
• Synonyms: NSC57663;benzamide, 2-amino-N-methyl-N-phenyl-;2-amino-N-methyl-N-phenylbenzamide(SALTDATA: FREE)
• CAS NO: 6632-37-7
• Molecular Formula: C₁₄H₁₄N₂O
• Molecular Weight: 226.278
• Mol File: 6632-37-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 405.7°C at 760 mmHg
• Flash Point: 199.2°C
• Appearance: /
• Density: 1.196g/cm³
• Vapor Pressure: 8.57E-07mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: NSC57663(CAS DataBase Reference)
• NIST Chemistry Reference: NSC57663(6632-37-7)
• EPA Substance Registry System: NSC57663(6632-37-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 6632-37-7(Hazardous Substances Data)

Usage

General Description

NSC57663, also known as 3-methyladenine (3-MA), is a chemical compound that acts as an inhibitor of the PI3K pathway. It is commonly used in research to inhibit autophagy and induce apoptosis. 3-MA has been found to promote cell death in cancer cells and has potential applications in cancer therapy. Additionally, it has been studied for its role in neuroprotection and as a potential treatment for neurodegenerative diseases. NSC57663 is a valuable tool in the study of cell signaling pathways and has the potential to be developed into novel therapeutic agents for various diseases.

InChI:InChI=1/C14H14N2O/c1-16(11-7-3-2-4-8-11)14(17)12-9-5-6-10-13(12)15/h2-10H,15H2,1H3

Upstream product

• 61899-13-6 N-methyl-N-phenyl-2-nitrobenzamide 
• 100-61-8 N-methylaniline 
• 21563-73-5 2-aminobenzoyl chloride 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 118-92-3 anthranilic acid 
• 118-48-9 isatoic anhydride 

Downstream Products

• 16347-60-7 3-phenyl-4(3H)-quinazolinone 
• 94871-77-9 2-benzamido-N-methyl-N-phenylbenzamide 
• 1616494-84-8 tert-butyl (2-(methyl(phenyl)carbamoyl)phenyl)carbamate 
• 93-98-1 N-phenyl benzoyl amide 
• 19263-38-8 2-methylspiro[cycloexa[2,5]diene-1,1’-isoindoline]-3’,4-dione 
• 4594-73-4 5-methylphenanthridin-6(5H)-one 
• 94459-51-5 2-acetamido-N-methyl-N-phenylbenzamide 
• 529-23-7 o-aminobenzaldehyde 

Relevant articles and documents

TBHP as Methyl Source under Metal-Free Aerobic Conditions To Synthesize Quinazolin-4(3H)-ones and Quinazolines by Oxidative Amination of C(sp3)–H Bond

tert-Butyl hydroperoxide (TBHP) served as the methyl source under metal-free aerobic conditions in the oxidative amination of the C(sp3)–H bond to synthesize quinazolin-4(3H)-ones and quinazolines from 2-aminobenzamides and 2-carbonyl-substituted anilines, respectively.

Radical cyclization and 1,5-hydrogen transfer in selected aromatic diazonium salts

2-(Methyl-(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbamoyl)thiophene- 3-diazonium hydrogen sulfate 20, 2-(methyl-(3-methylisoxazol-5-yl)carbamoyl)- benzenediazonium hydrogen sulfate 21 and 2-(methyl(phenyl)carbamoyl)- benzenediazonium hydrogen sulphate 22 were synthesized and reacted with a CuSO4/NaCl/ascorbic acid combination to give complex mixtures. The structures of the reaction products were elucidated, depending upon the pathways followed. Compound 20 almost exclusively afforded an Ar-5 cyclization product and trace amounts of the product derived from a competing Ar-6 Pschorr closure. In the case of compound 21, the Ar-6 cyclization was not observed, while the Ar-5 cyclization and 1,5-hydrogen radical transfer processes equally occurred. Finally, the Ar-6 cyclization was observed as the main process for compound 22, accompanied by the Ar-5 cyclization and, in a much lesser extent, by an 1,5-hydrogen radical transfer process.

O,O-Diethyldithiophosphoric acid. A new condensing agent for acylation of amines by carboxylic acid

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