6632-37-7

Usage

Uses

Used in Cancer Therapy:
NSC57663 is used as an autophagy inhibitor and apoptosis inducer for its potential role in cancer treatment. It has been observed to promote cell death in cancer cells, making it a promising agent for the development of therapeutic strategies against various types of cancer.
Used in Neuroprotection:
In the field of neurodegenerative diseases, NSC57663 is used as a potential treatment option. Its neuroprotective properties are currently being studied to explore its efficacy in safeguarding neurons and potentially slowing down the progression of neurodegenerative conditions.
Used in Research:
NSC57663 is used as a valuable tool in research for the study of cell signaling pathways. Its role in inhibiting the PI3K pathway and inducing autophagy and apoptosis makes it instrumental in advancing our understanding of cellular processes and the development of novel therapeutic agents for various diseases.

InChI:InChI=1/C14H14N2O/c1-16(11-7-3-2-4-8-11)14(17)12-9-5-6-10-13(12)15/h2-10H,15H2,1H3

Upstream product

• 118-48-9 isatoic anhydride 
• 100-61-8 N-methylaniline 
• 61899-13-6 N-methyl-N-phenyl-2-nitrobenzamide 
• 118-92-3 anthranilic acid 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 21563-73-5 2-aminobenzoyl chloride 

Downstream Products

• 529-23-7 o-aminobenzaldehyde 
• 94459-51-5 2-acetamido-N-methyl-N-phenylbenzamide 
• 93-98-1 N-phenyl benzoyl amide 
• 19263-38-8 2-methylspiro[cycloexa[2,5]diene-1,1’-isoindoline]-3’,4-dione 
• 4594-73-4 5-methylphenanthridin-6(5H)-one 
• 16347-60-7 3-phenyl-4(3H)-quinazolinone 
• 94871-77-9 2-benzamido-N-methyl-N-phenylbenzamide 
• 1616494-84-8 tert-butyl (2-(methyl(phenyl)carbamoyl)phenyl)carbamate 

Relevant academic research and scientific papers

TBHP as Methyl Source under Metal-Free Aerobic Conditions To Synthesize Quinazolin-4(3H)-ones and Quinazolines by Oxidative Amination of C(sp3)–H Bond

tert-Butyl hydroperoxide (TBHP) served as the methyl source under metal-free aerobic conditions in the oxidative amination of the C(sp3)–H bond to synthesize quinazolin-4(3H)-ones and quinazolines from 2-aminobenzamides and 2-carbonyl-substituted anilines, respectively.

Intramolecular metal-free oxidative aryl-aryl coupling: An unusual hypervalent-iodine-mediated rearrangement of 2-substituted n-phenylbenzamides

Hypervalent-iodine-mediated oxidative coupling of the two aryl groups in either 2-acylamino-N-phenyl-benzamides or 2-hydroxy-N-phenylbenzamides, with concomitant insertion of the ortho-substituted N or O atom into the tether, has been described for the first time. This unusual metal-free rearrangement reaction involves an oxidative C(sp2)?C(sp2) aryl-aryl bond formation, cleavage of a C(sp2)?C(O) bond, and a lactamization/lactonization. Furthermore, unsymmetrical diaryl compounds can be easily obtained by removing the tether within the cyclized product.

Radical cyclization and 1,5-hydrogen transfer in selected aromatic diazonium salts

2-(Methyl-(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbamoyl)thiophene- 3-diazonium hydrogen sulfate 20, 2-(methyl-(3-methylisoxazol-5-yl)carbamoyl)- benzenediazonium hydrogen sulfate 21 and 2-(methyl(phenyl)carbamoyl)- benzenediazonium hydrogen sulphate 22 were synthesized and reacted with a CuSO4/NaCl/ascorbic acid combination to give complex mixtures. The structures of the reaction products were elucidated, depending upon the pathways followed. Compound 20 almost exclusively afforded an Ar-5 cyclization product and trace amounts of the product derived from a competing Ar-6 Pschorr closure. In the case of compound 21, the Ar-6 cyclization was not observed, while the Ar-5 cyclization and 1,5-hydrogen radical transfer processes equally occurred. Finally, the Ar-6 cyclization was observed as the main process for compound 22, accompanied by the Ar-5 cyclization and, in a much lesser extent, by an 1,5-hydrogen radical transfer process.

Synthesis of tertiary amides from anionically activated aromatic trifluoromethyl groups

Figure presented In this paper, a novel synthesis of tertiary amides from anionically activated aromatic trifluoromethyl groups is presented. Anionically activated trifluoromethyl groups react with secondary amines under aqueous conditions to afford tertiary amides. The mechanism involves initial elimination of hydrogen fluoride by an E1cB mechanism to afford an electrophilic quinone methide- or azafulvene-type intermediate that reacts with secondary amines under aqueous conditions to afford the tertiary amide in good yield (up to 99%).