6633-46-1

Usage

Uses

Used in Environmental Monitoring:
3-Hydroxyfluoren-9-one is used as a biomarker for monitoring human exposure to PAHs. The presence and levels of this metabolite in biological samples can indicate the extent of exposure to PAHs, which are known to have adverse health effects.
Used in Toxicology Research:
In the field of toxicology, 3-hydroxyfluoren-9-one serves as a valuable tool for studying the toxic effects of PAHs on human health. By analyzing the levels of this metabolite, researchers can gain insights into the mechanisms of PAH-induced toxicity and develop strategies for prevention and treatment.
Used in Analytical Chemistry:
3-Hydroxyfluoren-9-one can be employed as a reference compound in the development and validation of analytical methods for the detection and quantification of PAHs in environmental and biological samples. Its unique chemical properties make it a suitable candidate for improving the accuracy and reliability of such methods.
Used in Pharmaceutical Research:
Due to its structural similarities with PAHs, 3-hydroxyfluoren-9-one may also have potential applications in the development of new drugs targeting PAH-related diseases or conditions. Researchers can use 3-hydroxyfluoren-9-one as a starting point for designing novel therapeutic agents with improved safety and efficacy profiles.

InChI:InChI=1/C13H8O2/c14-8-5-6-11-12(7-8)9-3-1-2-4-10(9)13(11)15/h1-7,14H

Upstream product

• 6710-43-6 2-indenone ethylene ketal 
• 4192-77-2 ethyl cinnamate 
• 615-41-8 2-iodochlorobenzene 
• 123-08-0 4-hydroxy-benzaldehyde 
• 13631-21-5 4-bromo-3-chlorophenol 
• 100-52-7 benzaldehyde 
• 1137-42-4 4-Hydroxybenzophenone 
• 833-39-6 4-hydroxy-benzhydrol 
• 106-41-2 4-bromo-phenol 
• 184773-35-1 3'-methoxy-biphenyl-2-carboxylic acid ethyl ester 
• 10365-98-7 3-methoxyphenylboronic acid 
• 6091-64-1 2-bromobenzoic acid ethyl ester 
• 15144-81-7 5-methoxy-[1,1′-biphenyl]-2-carboxylic acid 
• 15144-82-8 3-methoxy-fluoren-9-one 

Downstream Products

• 6344-67-8 3-hydroxyfluorene 
• 42839-83-8 3-hydroxy-2-morpholin-4-ylmethyl-fluoren-9-one 
• 416857-79-9 2,2-diphenyl-2H-pyrano[5,6-b]fluorenone 
• 1253118-46-5 3-(benzyloxy)-9H-fluoren-9-one 
• 416857-86-8 6-hydroxy-6-methyl-2,2-diphenyl-2H-pyrano[5,6-b]fluorene 

Relevant academic research and scientific papers

Palladium catalyzed domino C-H activation strategy: An access to 9- fluorenones

Palladium catalyzed domino C-H functionalization reaction of arylaldehyde with dihaloarene has been developed to access 9-flourenone molecules. Bidentate ligand assisted strategy, single step reaction, high yield and excellent functional group tolerance make this method concise and effective for the synthesis of 9-flourenone. In addition, proposed method has been successfully employed to synthesise Tilorone in gram scale.

Design, synthesis and evaluation of new GEQ derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth

A series of fluorene-based derivatives was synthesized and evaluated for inhibiting both InhA and Mycobacterium tuberculosis growth. These compounds were inspired by the previously reported Genz-10850 molecule, a good InhA inhibitor, but with a poor activity against M. tuberculosis growth. Structure-activity relationships were performed by introducing the following chemical modifications: 1) the piperazine ring; 2) the amide group; 3) the aryl moiety; and 4) the fluorene moiety. Among these new derivatives, one of them was more effective against both the InhA activity and mycobacterial growth, compared to the hit compound. Docking studies were also performed to rationalize activities of these derivatives. Furthermore, we showed for the first time that efflux pump inhibitors potentiated the efficacy of Genz-10850 (GEQ) derivatives against M. tuberculosis growth, demonstrating that these compounds could be substrates of some efflux pumps.

Synthesis of fluorenone derivatives through Pd-catalyzed dehydrogenative cyclization

Palladium-catalyzed dual C-H functionalization of benzophenones to form fluorenones by oxidative dehydrogenative cyclization is reported. This method provides a concise and effective route toward the synthesis of fluorenone derivatives, which shows outstanding functional group compatibility.

Bisphenolic compounds that enhance cell cation transport are found in commercial phenol red

We have isolated two bisphenolic compounds (4 and 5) that have a marked effect on K+ and Na+ concentrations in human cells from commercial preparations of the pH indicator dye phenol red (phenolsulfonphthalein). We used a bioassay to