6633-46-1

Basic information

• Product Name: 3-hydroxyfluoren-9-one
• Synonyms: 3-hydroxyfluoren-9-one;3-Hydroxy-9H-fluoren-9-one
• CAS NO: 6633-46-1
• Molecular Formula: C₁₃H₈O₂
• Molecular Weight: 196.2
• Mol File: 6633-46-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 377.9°C at 760 mmHg
• Flash Point: 161.3°C
• Appearance: /
• Density: 1.369g/cm³
• Vapor Pressure: 3E-06mmHg at 25°C
• Refractive Index: 1.707
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: 3-hydroxyfluoren-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxyfluoren-9-one(6633-46-1)
• EPA Substance Registry System: 3-hydroxyfluoren-9-one(6633-46-1)

Safety Data

• Hazardous Substances Data: 6633-46-1(Hazardous Substances Data)

Usage

Uses

3-Hydroxy-9H-fluoren-9-one is an metabolite of polycyclic aromatic hydrocarbons (PAH) that is used for biomonitoring human exposure to PAH.

InChI:InChI=1/C13H8O2/c14-8-5-6-11-12(7-8)9-3-1-2-4-10(9)13(11)15/h1-7,14H

Upstream product

• 85-29-0 2,4'-dichlorobenzophenone 
• 100527-37-5 3-hydroxy-9-oxo-fluorene-2-carboxylic acid 
• 15144-82-8 3-methoxy-fluoren-9-one 
• 15144-81-7 5-methoxy-[1,1′-biphenyl]-2-carboxylic acid 
• 6091-64-1 2-bromobenzoic acid ethyl ester 
• 10365-98-7 3-methoxyphenylboronic acid 
• 184773-35-1 3'-methoxy-biphenyl-2-carboxylic acid ethyl ester 
• 6710-43-6 2-indenone ethylene ketal 
• 4192-77-2 ethyl cinnamate 
• 615-41-8 2-iodochlorobenzene 
• 123-08-0 4-hydroxy-benzaldehyde 
• 13631-21-5 4-bromo-3-chlorophenol 
• 100-52-7 benzaldehyde 
• 1137-42-4 4-Hydroxybenzophenone 

Downstream Products

• 416857-79-9 2,2-diphenyl-2H-pyrano[5,6-b]fluorenone 
• 1253118-46-5 3-(benzyloxy)-9H-fluoren-9-one 
• 416857-86-8 6-hydroxy-6-methyl-2,2-diphenyl-2H-pyrano[5,6-b]fluorene 
• 42839-83-8 3-hydroxy-2-morpholin-4-ylmethyl-fluoren-9-one 
• 6344-67-8 3-hydroxyfluorene 

Relevant articles and documents

Palladium catalyzed domino C-H activation strategy: An access to 9- fluorenones

Palladium catalyzed domino C-H functionalization reaction of arylaldehyde with dihaloarene has been developed to access 9-flourenone molecules. Bidentate ligand assisted strategy, single step reaction, high yield and excellent functional group tolerance make this method concise and effective for the synthesis of 9-flourenone. In addition, proposed method has been successfully employed to synthesise Tilorone in gram scale.

Synthesis of fluorenone derivatives through Pd-catalyzed dehydrogenative cyclization

Palladium-catalyzed dual C-H functionalization of benzophenones to form fluorenones by oxidative dehydrogenative cyclization is reported. This method provides a concise and effective route toward the synthesis of fluorenone derivatives, which shows outstanding functional group compatibility.