66345-53-7

Basic information

• Product Name: (2S,3R)-1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pentan-3-ol
• CAS NO: 66345-53-7
• Molecular Formula: C₁₅H₂₀ClN₃O
• Molecular Weight: 293.7918
• Mol File: 66345-53-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 460.9°C at 760 mmHg
• Flash Point: 232.6°C
• Density: 1.19g/cm³
• Vapor Pressure: 2.72E-09mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: (2S,3R)-1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pentan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pentan-3-ol(66345-53-7)
• EPA Substance Registry System: (2S,3R)-1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pentan-3-ol(66345-53-7)

Safety Data

• Hazardous Substances Data: 66345-53-7(Hazardous Substances Data)

Usage

Description

(2S,3R)-1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pentan-3-ol, also known as isavuconazonium sulfate, is a medication belonging to the class of triazoles. It is used for the treatment of invasive aspergillosis and invasive mucormycosis, serious fungal infections. As a prodrug, it is converted into its active form in the body, where it inhibits fungal growth by interfering with the synthesis of ergosterol, an essential component of the fungal cell membrane.

Uses

Used in Pharmaceutical Industry:
Isavuconazonium sulfate is used as an antifungal agent for the treatment of invasive aspergillosis and invasive mucormycosis. Its application is based on its ability to inhibit the growth of fungi by interfering with the synthesis of ergosterol, leading to the death of the fungus. It is available in both intravenous and oral formulations, making it a valuable option for treating serious fungal infections.

Upstream product

• 63190-87-4 1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pentan-3-one 
• 5469-26-1 1-Bromopinacolon 
• 109-65-9 1-bromo-butane 
• 693-03-8 n-butyl magnesium bromide 
• 66346-00-7 α-(1,2,4-triazol-1-yl)-α-p-chlorobenzylchloride 
• 66346-01-8 1-(4-chlorophenyl)-4,4-dimethyl-pentan-3-one 
• 58905-32-1 3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanone 
• 75-97-8 3,3-dimethyl-butan-2-one 

Relevant articles and documents

New lead compounds for brassinosteroid biosynthesis inhibitors

The first brassinosteroid biosynthesis inhibitor is reported. Among newly synthesized triazole derivatives, 4-(4-chlorophenyl)-2-phenyl-3- (1,2,4-triazoyl)butan-2-ol (6) was found to inhibit the growth of cress seedlings, and this inhibition was recovered by the treatment of brassinolide, suggesting that compound 6 primarily inhibits brassinosteroid biosynthesis.

Method for the treatment of plants with agrochemical tablet compositions

Novel method for applying agrochemicals to plants, which method consists in attaching to the surface of the plants tablets comprising at least one agrochemically active compound and at least one adjuvant, which is solid, liquid of pasty at room temperature, and optionally, one or more excipients optionally in admixture with one or more other additives and/or water.

Combating fungi with triazolyl-benzyloxy-ketones and-carbinols

Triazolyl-benzyloxy-ketones or carbinols of the formula STR1 in which A is a keto group or a CH(OH) group, X is a halogen atom or an alkyl or halogenoalkyl radical, and n is 0, 1, 2, 3, 4 or 5, or an addition product thereof with a physiologically acceptable acid or metal salt, which possess fungicidal properties. Intermediates wherein A is a keto group and the azole group is replaced by chloride or bromine are also new.