6636-13-1Relevant academic research and scientific papers
Ring opening of N-sulfonyl aziridines by amines in silica-water
Li, Tiantian,Ma, Xiaosi,Qi, Junmei,Sun, Feifei,Ma, Ning
, p. 1135 - 1142 (2015/01/09)
Ring opening reactions of N-sulfonyl aziridines by primary and secondary amines in silica gel (SG)-water system were achieved, which provided a mild, practical and environmentally benign method to synthesize mono- and bis-sulfonyl substituted amines. When
Divergent structure-activity relationships of structurally similar acetylcholinesterase inhibitors
Andersson, C. David,Forsgren, Nina,Akfur, Christine,Allgardsson, Anders,Berg, Lotta,Engdahl, Cecilia,Qian, Weixing,Ekstr?m, Fredrik,Linusson, Anna
, p. 7615 - 7624 (2013/11/06)
The molecular interactions between the enzyme acetylcholinesterase (AChE) and two compound classes consisting of N-[2-(diethylamino)ethyl] benzenesulfonamides and N-[2-(diethylamino)ethyl]benzenemethanesulfonamides have been investigated using organic synthesis, enzymatic assays, X-ray crystallography, and thermodynamic profiling. The inhibitors' aromatic properties were varied to establish structure-activity relationships (SAR) between the inhibitors and the peripheral anionic site (PAS) of AChE. The two structurally similar compound classes proved to have distinctly divergent SARs in terms of their inhibition capacity of AChE. Eight X-ray structures revealed that the two sets have different conformations in PAS. Furthermore, thermodynamic profiles of the binding between compounds and AChE revealed class-dependent differences of the entropy/enthalpy contributions to the free energy of binding. Further development of the entropy-favored compound class resulted in the synthesis of the most potent inhibitor and an extension beyond the established SARs. The divergent SARs will be utilized to develop reversible inhibitors of AChE into reactivators of nerve agent-inhibited AChE.
