6637-46-3

Usage

Uses

Used in Pharmaceutical Synthesis:
[4-(2,5-dioxopyrrol-1-yl)phenyl] acetate is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the formation of complex drug molecules. Its unique structure allows for further chemical reactions, facilitating the development of new medications.
Used in Organic Compounds Synthesis:
[4-(2,5-dioxopyrrol-1-yl)phenyl] acetate is also used as an intermediate in the synthesis of various organic compounds, where its reactive functional groups can be utilized to create a wide range of products with different properties and applications.
Used in Dye and Pigment Manufacturing:
[4-(2,5-dioxopyrrol-1-yl)phenyl] acetate has potential use in the manufacture of dyes and pigments, thanks to its chemical structure that can contribute to the color properties of these products. Its incorporation in the production process can lead to the development of new dyes and pigments with improved characteristics.
Used in Chemical Industry:
[4-(2,5-dioxopyrrol-1-yl)phenyl] acetate's versatility makes it a valuable asset in the chemical industry, where it can be employed in various processes and reactions to produce a range of products with different applications, from coatings to specialty chemicals.

InChI:InChI=1/C12H9NO4/c1-8(14)17-10-4-2-9(3-5-10)13-11(15)6-7-12(13)16/h2-7H,1H3

Upstream product

• 108-31-6 maleic anhydride 
• 13871-68-6 p-aminophenyl acetate 
• 7300-91-6 N-(4-hydroxyphenyl)maleimide 
• 108-24-7 acetic anhydride 
• 143629-26-9 4'-hydroxymaleanilic acid 
• 127-09-3 sodium acetate 

Downstream Products

• 1360824-96-9 (1R,3aS,6aR)-methyl 5-(4-acetoxyphenyl)-4,6-dioxo-3-phenyl-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrrole-1-carboxylate 
• 1018166-95-4 N-(4-acetoxyphenyl)-2-{2-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1- yl]-4-oxo-4,5-dihydrothiazol-5-yl}acetamide 
• 1416427-50-3 C₁₆H₁₇NO₅ 
• 7300-91-6 N-(4-hydroxyphenyl)maleimide 
• 78049-92-0 Acetic acid 4-((2S,6R)-1,7,8,9-tetrabromo-10,10-dimethoxy-3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-phenyl ester 
• 78049-92-0 Acetic acid 4-(1,7,8,9-tetrabromo-10,10-dimethoxy-3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-phenyl ester 
• 78080-68-9 Acetic acid 4-((2S,6R)-1,7,8,9,10,10-hexabromo-3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-phenyl ester 
• 81624-21-7 Acetic acid 4-(1,7,8,9,10,10-hexabromo-3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-phenyl ester 

Relevant academic research and scientific papers

Access to indoles via Diels-Alder reactions of 2-vinylpyrroles with maleimides

(Chemical Equation Presented) Variously substituted 2-vinylpyrroles underwent an endo-addition [4+2] cycloaddition reaction with maleimides followed by a spontaneous highly diastereoselective (93-98% de) isomerization to give tetrahydroindoles in moderate to excellent yield. Treatment with activated MnO2 in refluxing toluene provided the corresponding indoles in moderate to good yield. This highly convergent methodology for formation of indoles is versatile and the starting materials are conveniently prepared.

Composition for forming organic insulating film and organic insulating film formed from the same

Disclosed herein is a composition for forming an organic insulating film and an organic insulating film formed from the composition. An exemplary composition comprises an insulating polymer having a maleimide structure, a crosslinking agent and a photoacid generator so as to form a crosslinked structure. The organic insulating film has excellent chemical resistance to organic solvents used in a subsequent photolithographic process and can improve the electrical properties of transistors.

Solvent-free synthesis of arylamides and arylimides, analogues of acetylcholine

Several arylamides and arylimides, novel inhibitors of acetylcholinesterase, were obtained under solventless conditions; the target molecules were produced with a good overall yield and short reaction times. 2017-2023 Copyright Taylor & Francis, Inc.

Reversible and irreversible inhibitory activity of succinic and maleic acid derivatives on acetylcholinesterase

Aryl succinic and maleic acid derivatives are potent inhibitors of bovine acetylcholinesterase in vitro. Succinic acid aminophenol derivatives 1b-e and 2b-d act as reversible inhibitors of acetylcholinesterase, while maleic acid aminophenol derivatives 3b-d and 4c-e act as choline subsite-directed irreversible inhibitors, detected by dialysis in the presence of edrophonium. Linear relationships between the logarithm of the velocity of hydrolysis of acetylcholine plotted against the time of incubation at several different inhibitor concentrations were determined. The Ki for reversible competitive inhibitors was determined. For irreversible inhibitors the Ki for the dissociation constant of the enzyme-inhibitor complex at the beginning of the recognition process was also determined as well as the inactivation constant of the enzyme-inhibitor adduct formation k+2 and the bimolecular inhibition constant ki for the inhibition of acetylcholinesterase by aminophenol derivatives 3b-d and 4c-e. The conclusions of this study can be summarized as follows for both families: (a) the aromatic moiety played a critical role in the recognition of the active site; (b) in case of the reversible inhibitor, when the ester function took the place of the hydroxyl fragment, there was an important increase in the affinity; and (c) the distance between phenolic hydroxyl and nitrogen was critical because the inhibition is ortho?metapara.

Synthesis and antimicrobial activities of N-substituted imides

In the field of our research programs concerning novel antimicrobial agents, a series of N-substituted imides was synthesized. These compounds were obtained by cyclization of amido-acids in acetic anhydride/sodium acetate or hexamethyldisilazane/zinc bromide for the hydroxy-aromatic derivatives. The hydroxy-alkyl maleimides were directly prepared by condensation of the corresponding amino-alcohol with maleic anhydride in boiling toluene. Most of N-substituted maleimides showed an interesting antimicrobial activity towards bacteria from the ATCC collection (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853) but the MIC values for P. aeruginosa were always high (128 μg/ml). The imides with alkyl substituents showed higher activities than aromatic analogues with MIC values in the range of 8-32 μg/ml. Comparatively, succinimides were practically inactive.

1H and 13C NMR spectra for a series of arylmaleamic acids, arylmaleimides, arylsuccinamic acids and arylsuccinimides

The 1H and 13C NMR spectra of 17 succinic anhydride derivatives and 25 maleic anhydride derivatives were completely assigned using one- and two-dimensional NMR techniques. Copyright