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7300-91-6 Usage

Uses

N-(4-Hydroxyphenyl)maleimide

Check Digit Verification of cas no

The CAS Registry Mumber 7300-91-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,3,0 and 0 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 7300-91:
(6*7)+(5*3)+(4*0)+(3*0)+(2*9)+(1*1)=76
76 % 10 = 6
So 7300-91-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H7NO3/c12-8-3-1-7(2-4-8)11-9(13)5-6-10(11)14/h1-6,12H

7300-91-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-hydroxyphenyl)pyrrole-2,5-dione

1.2 Other means of identification

Product number -
Other names 4-hydroxyphenylmaleimide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7300-91-6 SDS

7300-91-6Synthetic route

maleic anhydride
108-31-6

maleic anhydride

4-amino-phenol
123-30-8

4-amino-phenol

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
Stage #1: maleic anhydride; 4-amino-phenol In acetone at 20℃; for 1h;
Stage #2: With sodium acetate; triethylamine; hydroquinone In toluene at 115℃; for 2.5h;
88.5%
Stage #1: maleic anhydride; 4-amino-phenol In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: With phosphorus pentoxide; sulfuric acid In N,N-dimethyl-formamide at 70℃; for 2h;
84%
With sulfuric acid; phosphorus pentoxide In N,N-dimethyl-formamide at 70℃; for 2h;56.8%
4'-hydroxymaleanilic acid
143629-26-9, 28173-23-1

4'-hydroxymaleanilic acid

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
With 1,1,1,3,3,3-hexamethyl-disilazane; zinc dibromide In toluene for 6h; Heating;85%
With sodium acetate; acetic anhydride In tetrahydrofuran at 60℃; for 8h;83.3%
With toluene-4-sulfonic acid; N,N-dimethyl-formamide In toluene at 110℃;64%
C11H11NO3

C11H11NO3

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane Reflux;72%
4-(acetoxyphenyl)maleimide
6637-46-3

4-(acetoxyphenyl)maleimide

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid; water63%
N-(4-hydroxy-phenyl)-maleamic acid
28173-23-1, 143629-26-9

N-(4-hydroxy-phenyl)-maleamic acid

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
With acetyl chloride; acetone
With toluene-4-sulfonic acid In N,N-dimethyl-formamide; toluene at 110℃;
With toluene-4-sulfonic acid In N,N-dimethyl-formamide; toluene at 110℃;
exo-4-dodecyl-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxy-N-(4-hydroxyphenyl)imide

exo-4-dodecyl-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxy-N-(4-hydroxyphenyl)imide

A

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

B

2-(n-dodecyl)furan
75308-12-2

2-(n-dodecyl)furan

Conditions
ConditionsYield
In dimethylsulfoxide-d6 at 50 - 105℃; Reactivity;
4-amino-phenol
123-30-8

4-amino-phenol

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetone / 2 h / 20 °C
2: toluene-4-sulfonic acid / N,N-dimethyl-formamide; toluene / 110 °C
View Scheme
Multi-step reaction with 2 steps
1: acetone / 2 h / 20 °C
2: toluene-4-sulfonic acid; N,N-dimethyl-formamide / toluene / 110 °C
View Scheme
Multi-step reaction with 2 steps
1: acetone / 2 h / 20 °C
2: toluene-4-sulfonic acid / N,N-dimethyl-formamide; toluene / 110 °C
View Scheme
maleic anhydride
108-31-6

maleic anhydride

C21H26N2O2

C21H26N2O2

4-amino-phenol
123-30-8

4-amino-phenol

A

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

B

C29H26N2O6

C29H26N2O6

Conditions
ConditionsYield
In N,N-dimethyl-formamide; toluene at 20℃; for 2h; Dean-Stark; Cooling with ice;
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

phenyl chloroformate
1885-14-9

phenyl chloroformate

C17H11NO5

C17H11NO5

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 3h;97%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

2-(n-dodecyl)furan
75308-12-2

2-(n-dodecyl)furan

exo-4-dodecyl-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxy-N-(4-hydroxyphenyl)imide

exo-4-dodecyl-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxy-N-(4-hydroxyphenyl)imide

Conditions
ConditionsYield
In acetone at 55℃;96%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

C26H17N2O8P

C26H17N2O8P

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 5 - 7℃; Temperature;95.3%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

cinnamoyl chloride
102-92-1

cinnamoyl chloride

3-phenylacrylic acid 4-(2,5-dioxo-2,5-dihydropyrrole-1-yl)-phenyl ester

3-phenylacrylic acid 4-(2,5-dioxo-2,5-dihydropyrrole-1-yl)-phenyl ester

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide 0 deg C, 1 h; 25 deg C, 2 h;95.1%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

diphenylolpropane diglycidyl ether
1675-54-3

diphenylolpropane diglycidyl ether

C31H31NO7

C31H31NO7

Conditions
ConditionsYield
With triphenylphosphine In butanone at 130 - 140℃; for 4h;90%
oxalyl dichloride
79-37-8

oxalyl dichloride

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

bis(4maleimidophenyl)oxalate

bis(4maleimidophenyl)oxalate

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 0℃; for 2h;90%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

aniline
62-53-3

aniline

N-(3-phenylazo-4-hydroxyphenyl)maleimide
1252759-89-9

N-(3-phenylazo-4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
Stage #1: aniline With hydrogenchloride; sodium nitrite In water at 0 - 5℃;
Stage #2: N-(4-hydroxyphenyl)maleimide With sodium hydroxide In water at 0 - 5℃; for 0.166667h;
85%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

4-amino-phenol
123-30-8

4-amino-phenol

N-(3-(4-hydroxyphenylazo)-4-hydroxyphenyl)maleimide
1252759-90-2

N-(3-(4-hydroxyphenylazo)-4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
Stage #1: 4-amino-phenol With hydrogenchloride; sodium nitrite In water at 0 - 5℃;
Stage #2: N-(4-hydroxyphenyl)maleimide With sodium hydroxide In water at 0 - 5℃; for 0.166667h;
81%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

epichlorohydrin
106-89-8

epichlorohydrin

4-(N-maleimido)phenyl glycidyl ether
70657-11-3

4-(N-maleimido)phenyl glycidyl ether

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 20℃; for 48h;80%
With benzyltrimethylammonium chloride at 60℃; for 24h; Inert atmosphere;75%
With benzyltrimethylammonium chloride at 60℃; for 24h; Inert atmosphere;55%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

p-toluidine
106-49-0

p-toluidine

N-(3-(4-methylphenylazo)-4-hydroxyphenyl)maleimide
1252759-91-3

N-(3-(4-methylphenylazo)-4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
Stage #1: p-toluidine With hydrogenchloride; sodium nitrite In water at 0 - 5℃;
Stage #2: N-(4-hydroxyphenyl)maleimide With sodium hydroxide In water at 0 - 5℃; for 0.166667h;
80%
(4S,7R,8S,9S,13Z,16S)-chloroformic acid-7-allyl-4-(tert-butyl-dimethyl-silanyloxy)-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-2,6-dioxo-oxacyclohexadec-13-en-8-yl ester

(4S,7R,8S,9S,13Z,16S)-chloroformic acid-7-allyl-4-(tert-butyl-dimethyl-silanyloxy)-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-2,6-dioxo-oxacyclohexadec-13-en-8-yl ester

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

(4S,7R,8S,9S,13Z,16S)-carbonic acid 7-allyl-4-(tert-butyl-dimethyl-silanyloxy)-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-2,6-dioxo-oxacyclohexadec-13-en-8-yl ester 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl ester
658054-31-0

(4S,7R,8S,9S,13Z,16S)-carbonic acid 7-allyl-4-(tert-butyl-dimethyl-silanyloxy)-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-2,6-dioxo-oxacyclohexadec-13-en-8-yl ester 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl ester

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 23℃; for 16h;79%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

N-(2-pyridyl)indole
3419-91-8

N-(2-pyridyl)indole

1-(4-hydroxyphenyl)-3-(1-(pyridin-2-yl)-1H-indol-2-yl)pyrrolidine-2,5-dione

1-(4-hydroxyphenyl)-3-(1-(pyridin-2-yl)-1H-indol-2-yl)pyrrolidine-2,5-dione

Conditions
ConditionsYield
With dimanganese decacarbonyl In ethyl acetate at 120℃; for 12h;78%
maleic anhydride
108-31-6

maleic anhydride

4-amino-phenol
123-30-8

4-amino-phenol

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
Stage #1: maleic anhydride; 4-amino-phenol In acetone at 20℃; for 1h;
Stage #2: With sodium acetate; triethylamine; hydroquinone In toluene at 115℃; for 2.5h;
88.5%
Stage #1: maleic anhydride; 4-amino-phenol In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: With phosphorus pentoxide; sulfuric acid In N,N-dimethyl-formamide at 70℃; for 2h;
84%
With sulfuric acid; phosphorus pentoxide In N,N-dimethyl-formamide at 70℃; for 2h;56.8%
4'-hydroxymaleanilic acid
143629-26-9, 28173-23-1

4'-hydroxymaleanilic acid

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
With 1,1,1,3,3,3-hexamethyl-disilazane; zinc dibromide In toluene for 6h; Heating;85%
With sodium acetate; acetic anhydride In tetrahydrofuran at 60℃; for 8h;83.3%
With toluene-4-sulfonic acid; N,N-dimethyl-formamide In toluene at 110℃;64%
C11H11NO3

C11H11NO3

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane Reflux;72%
4-(acetoxyphenyl)maleimide
6637-46-3

4-(acetoxyphenyl)maleimide

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid; water63%
N-(4-hydroxy-phenyl)-maleamic acid
28173-23-1, 143629-26-9

N-(4-hydroxy-phenyl)-maleamic acid

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
With acetyl chloride; acetone
With toluene-4-sulfonic acid In N,N-dimethyl-formamide; toluene at 110℃;
With toluene-4-sulfonic acid In N,N-dimethyl-formamide; toluene at 110℃;
exo-4-dodecyl-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxy-N-(4-hydroxyphenyl)imide

exo-4-dodecyl-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxy-N-(4-hydroxyphenyl)imide

A

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

B

2-(n-dodecyl)furan
75308-12-2

2-(n-dodecyl)furan

Conditions
ConditionsYield
In dimethylsulfoxide-d6 at 50 - 105℃; Reactivity;
4-amino-phenol
123-30-8

4-amino-phenol

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetone / 2 h / 20 °C
2: toluene-4-sulfonic acid / N,N-dimethyl-formamide; toluene / 110 °C
View Scheme
Multi-step reaction with 2 steps
1: acetone / 2 h / 20 °C
2: toluene-4-sulfonic acid; N,N-dimethyl-formamide / toluene / 110 °C
View Scheme
Multi-step reaction with 2 steps
1: acetone / 2 h / 20 °C
2: toluene-4-sulfonic acid / N,N-dimethyl-formamide; toluene / 110 °C
View Scheme
maleic anhydride
108-31-6

maleic anhydride

C21H26N2O2

C21H26N2O2

4-amino-phenol
123-30-8

4-amino-phenol

A

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

B

C29H26N2O6

C29H26N2O6

Conditions
ConditionsYield
In N,N-dimethyl-formamide; toluene at 20℃; for 2h; Dean-Stark; Cooling with ice;
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

phenyl chloroformate
1885-14-9

phenyl chloroformate

C17H11NO5

C17H11NO5

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 3h;97%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

2-(n-dodecyl)furan
75308-12-2

2-(n-dodecyl)furan

exo-4-dodecyl-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxy-N-(4-hydroxyphenyl)imide

exo-4-dodecyl-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxy-N-(4-hydroxyphenyl)imide

Conditions
ConditionsYield
In acetone at 55℃;96%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

C26H17N2O8P

C26H17N2O8P

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 5 - 7℃; Temperature;95.3%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

cinnamoyl chloride
102-92-1

cinnamoyl chloride

3-phenylacrylic acid 4-(2,5-dioxo-2,5-dihydropyrrole-1-yl)-phenyl ester

3-phenylacrylic acid 4-(2,5-dioxo-2,5-dihydropyrrole-1-yl)-phenyl ester

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide 0 deg C, 1 h; 25 deg C, 2 h;95.1%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

diphenylolpropane diglycidyl ether
1675-54-3

diphenylolpropane diglycidyl ether

C31H31NO7

C31H31NO7

Conditions
ConditionsYield
With triphenylphosphine In butanone at 130 - 140℃; for 4h;90%
oxalyl dichloride
79-37-8

oxalyl dichloride

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

bis(4maleimidophenyl)oxalate

bis(4maleimidophenyl)oxalate

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 0℃; for 2h;90%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

aniline
62-53-3

aniline

N-(3-phenylazo-4-hydroxyphenyl)maleimide
1252759-89-9

N-(3-phenylazo-4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
Stage #1: aniline With hydrogenchloride; sodium nitrite In water at 0 - 5℃;
Stage #2: N-(4-hydroxyphenyl)maleimide With sodium hydroxide In water at 0 - 5℃; for 0.166667h;
85%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

4-amino-phenol
123-30-8

4-amino-phenol

N-(3-(4-hydroxyphenylazo)-4-hydroxyphenyl)maleimide
1252759-90-2

N-(3-(4-hydroxyphenylazo)-4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
Stage #1: 4-amino-phenol With hydrogenchloride; sodium nitrite In water at 0 - 5℃;
Stage #2: N-(4-hydroxyphenyl)maleimide With sodium hydroxide In water at 0 - 5℃; for 0.166667h;
81%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

epichlorohydrin
106-89-8

epichlorohydrin

4-(N-maleimido)phenyl glycidyl ether
70657-11-3

4-(N-maleimido)phenyl glycidyl ether

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 20℃; for 48h;80%
With benzyltrimethylammonium chloride at 60℃; for 24h; Inert atmosphere;75%
With benzyltrimethylammonium chloride at 60℃; for 24h; Inert atmosphere;55%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

p-toluidine
106-49-0

p-toluidine

N-(3-(4-methylphenylazo)-4-hydroxyphenyl)maleimide
1252759-91-3

N-(3-(4-methylphenylazo)-4-hydroxyphenyl)maleimide

Conditions
ConditionsYield
Stage #1: p-toluidine With hydrogenchloride; sodium nitrite In water at 0 - 5℃;
Stage #2: N-(4-hydroxyphenyl)maleimide With sodium hydroxide In water at 0 - 5℃; for 0.166667h;
80%
(4S,7R,8S,9S,13Z,16S)-chloroformic acid-7-allyl-4-(tert-butyl-dimethyl-silanyloxy)-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-2,6-dioxo-oxacyclohexadec-13-en-8-yl ester

(4S,7R,8S,9S,13Z,16S)-chloroformic acid-7-allyl-4-(tert-butyl-dimethyl-silanyloxy)-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-2,6-dioxo-oxacyclohexadec-13-en-8-yl ester

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

(4S,7R,8S,9S,13Z,16S)-carbonic acid 7-allyl-4-(tert-butyl-dimethyl-silanyloxy)-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-2,6-dioxo-oxacyclohexadec-13-en-8-yl ester 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl ester
658054-31-0

(4S,7R,8S,9S,13Z,16S)-carbonic acid 7-allyl-4-(tert-butyl-dimethyl-silanyloxy)-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-2,6-dioxo-oxacyclohexadec-13-en-8-yl ester 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl ester

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 23℃; for 16h;79%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

N-(2-pyridyl)indole
3419-91-8

N-(2-pyridyl)indole

1-(4-hydroxyphenyl)-3-(1-(pyridin-2-yl)-1H-indol-2-yl)pyrrolidine-2,5-dione

1-(4-hydroxyphenyl)-3-(1-(pyridin-2-yl)-1H-indol-2-yl)pyrrolidine-2,5-dione

Conditions
ConditionsYield
With dimanganese decacarbonyl In ethyl acetate at 120℃; for 12h;78%
formaldehyd
50-00-0

formaldehyd

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

bicyclo[4.2.0]octa-1,3,5-trien-4-amine
55716-66-0

bicyclo[4.2.0]octa-1,3,5-trien-4-amine

N-(3-(benzocyclobutane-4-yl)-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-yl)maleimide
1417577-58-2

N-(3-(benzocyclobutane-4-yl)-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-yl)maleimide

Conditions
ConditionsYield
In 1,4-dioxane for 12h; Reflux;76%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

1-<2-(p-Chlorophenyl)-3-indolylmethylene>thiosemicarbazide
125471-31-0

1-<2-(p-Chlorophenyl)-3-indolylmethylene>thiosemicarbazide

2-(2-{[2-(4-chlorophenyl)-1H-indol-3-ylmethylene]hydrazono}-4-oxothiazolidin-5-yl)-N-(4-hydroxyphenyl)acetamide

2-(2-{[2-(4-chlorophenyl)-1H-indol-3-ylmethylene]hydrazono}-4-oxothiazolidin-5-yl)-N-(4-hydroxyphenyl)acetamide

Conditions
ConditionsYield
With sodium acetate; acetic acid Reflux;76%
formaldehyd
50-00-0

formaldehyd

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

furan-2-ylmethanamine
617-89-0

furan-2-ylmethanamine

1-(3-(furan-2-ylmethyl)-3,4-dihydro-2Hbenzo[e][1,3]oxazin-6-yl)-1H-pyrrole-2,5-dione

1-(3-(furan-2-ylmethyl)-3,4-dihydro-2Hbenzo[e][1,3]oxazin-6-yl)-1H-pyrrole-2,5-dione

Conditions
ConditionsYield
In toluene at 100℃; for 6h; Temperature;75.7%
In toluene at 100℃; for 3h;71%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

(S)-methyl 2-acetamido-3-(1-(pyridin-2-yl)-1H-indol-3-yl)propanoate

(S)-methyl 2-acetamido-3-(1-(pyridin-2-yl)-1H-indol-3-yl)propanoate

(S)-methyl 2-acetamido-3-(2-(1-(4-hydroxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1-(pyridin-2-yl)-1H-indol-3-yl)propanoate

(S)-methyl 2-acetamido-3-(2-(1-(4-hydroxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1-(pyridin-2-yl)-1H-indol-3-yl)propanoate

Conditions
ConditionsYield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) acetate; silver(l) oxide In acetonitrile at 80℃; for 2h; Inert atmosphere;72%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

5'-(4-hydroxyphenyl)-2'-phenylspiro[(3H)indol-3,3'(3'aH)[2H]pyrrolo[3,4-d]isoxazole]-2,4',6'-(1H,5'H,6'aH)trione

5'-(4-hydroxyphenyl)-2'-phenylspiro[(3H)indol-3,3'(3'aH)[2H]pyrrolo[3,4-d]isoxazole]-2,4',6'-(1H,5'H,6'aH)trione

Conditions
ConditionsYield
In acetonitrile Inert atmosphere; Reflux; diastereoselective reaction;70%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

(2-phenyl-1H-indol-3-yl)-methylenethiosemicarbazone
125471-32-1

(2-phenyl-1H-indol-3-yl)-methylenethiosemicarbazone

N-(4-hydroxyphenyl)-2-{4-oxo-2-[(2-phenyl-1H-indol-3-ylmethylene)hydrazono]thiazolidin-5-yl}acetamide

N-(4-hydroxyphenyl)-2-{4-oxo-2-[(2-phenyl-1H-indol-3-ylmethylene)hydrazono]thiazolidin-5-yl}acetamide

Conditions
ConditionsYield
With sodium acetate; acetic acid Reflux;68%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

Hexamethylene diisocyanate
822-06-0

Hexamethylene diisocyanate

{6-[4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenoxycarbonylamino]-hexyl}-carbamic acid 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl ester

{6-[4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenoxycarbonylamino]-hexyl}-carbamic acid 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl ester

Conditions
ConditionsYield
With triethylamine In toluene for 13h; Heating;67%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

octaperfluorocyclopentene
559-40-0

octaperfluorocyclopentene

C25H12F6N2O6

C25H12F6N2O6

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 0 - 50℃; for 3h;61%
(4S,7R,8S,9S,13Z,16S)-chloroformic acid-7-allyl-8-(tert-butyl-dimethyl-silanyloxy)-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-2,6-dioxo-oxacyclohexadec-13-en-4-yl ester
658054-22-9

(4S,7R,8S,9S,13Z,16S)-chloroformic acid-7-allyl-8-(tert-butyl-dimethyl-silanyloxy)-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-2,6-dioxo-oxacyclohexadec-13-en-4-yl ester

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

(4S,7R,8S,9S,13Z,16S)-carbonic acid 7-allyl-8-(tert-butyl-dimethyl-silanyloxy)-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-2,6-dioxo-oxacyclohexadec-13-en-4-yl ester 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl ester
658054-23-0

(4S,7R,8S,9S,13Z,16S)-carbonic acid 7-allyl-8-(tert-butyl-dimethyl-silanyloxy)-5,5,9,13-tetramethyl-16-(2-methyl-benzothiazol-5-yl)-2,6-dioxo-oxacyclohexadec-13-en-4-yl ester 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl ester

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 23℃; for 16h;59%
furan
110-00-9

furan

N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

2-(4-hydroxyphenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

2-(4-hydroxyphenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

Conditions
ConditionsYield
In acetone at -35 - 75℃; for 1h;57%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

((Z)-2-But-1-enyl)-1H-pyrrole

((Z)-2-But-1-enyl)-1H-pyrrole

4α-ethyl-2-(4-hydroxyphenyl)-3aα,4β,5,8bα-tetrahydro-2H,6H-pyrrolo[3,4-e]indole-1,3-dione

4α-ethyl-2-(4-hydroxyphenyl)-3aα,4β,5,8bα-tetrahydro-2H,6H-pyrrolo[3,4-e]indole-1,3-dione

Conditions
ConditionsYield
In toluene for 24h; Diels-Alder reaction; Reflux;54%
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

N,N-dimethyl-aniline
121-69-7

N,N-dimethyl-aniline

2-(4-hydroxyphenyl)-5-methyl-3a,4,5,9b-tetrahydro-1H-pyrrolo[3,4-c]quinoline-1,3(2H)-dione

2-(4-hydroxyphenyl)-5-methyl-3a,4,5,9b-tetrahydro-1H-pyrrolo[3,4-c]quinoline-1,3(2H)-dione

Conditions
ConditionsYield
With alizarin red S sensitized TiO2; air In acetonitrile at 30℃; for 20h; Irradiation;54%
With cadmium sulphide In neat (no solvent) at 20℃; for 36h; Irradiation;90 %Chromat.
N-(4-hydroxyphenyl)maleimide
7300-91-6

N-(4-hydroxyphenyl)maleimide

5-fluoro-2-methoxybenzoic acid
394-04-7

5-fluoro-2-methoxybenzoic acid

C17H14FNO4

C17H14FNO4

Conditions
ConditionsYield
With sodium dihydrogenphosphate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; water at 85℃; for 16h; Green chemistry; chemoselective reaction;50%

7300-91-6Relevant articles and documents

Optimal synthetic design of second-order nonlinear optical material with good temporal stability

Choi,Song,Jahng,Kim

, p. 17 - 26 (1996)

Second-order nonlinear optical copolymers containing p-hydroxyphenyl maleimide or 4-cinnamoyloxy-phenylmaleimide as a comonomer were newly synthesized. For improving the temporal stability, we adopted the crosslink reaction thermally and photochemically. Second-order nonlinear optical properties of the poled/cured films were investigated in terms of the second harmonic generation (SHG) and linear electro-optic (EO) coefficient measurement. SHG coefficient, d33 was found to be 14 pm/V at the fundamental wavelength of 1064 nm and EO coefficient, r33 was found to be 25-30 pm/V at 633 nm wavelength in two different crosslinked structures. To prevent the orientational relaxation of poled polymer, thermal crosslink reaction was induced using diisocyanate as a crosslinker between the side chains themselves. Another photo-crosslink was induced exposing the film at 257 nm wavelength during poling. Temporal stabilities of second-order NLO coefficients of crosslinked polymer systems were proved much better than that of guest-host system or other side chain polymers.

Application of maleimide compound as chitin synthase inhibitor

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Paragraph 0120-0123; 0136-0139, (2020/07/12)

The invention discloses an application of a maleimide compound as shown in a formula I. In the formula I, R0 is phenyl, benzyl, phenethyl, phenylpropyl, p-fluorophenyl, p-chlorophenyl, p-bromophenyl,p-methoxyphenyl, p-methylphenyl or p-hydroxyphenyl, R1 is hydrogen, methyl, phenyl or chlorine; and R2 is hydrogen, methyl, phenyl or chlorine. The provided maleimide compound has a good inhibition effect on chitin synthase.

Monomer compound and preparation method thereof, and copolymer, preparation method and applications thereof

-

Paragraph 0085-0087; 0090; 0091; 0115; 0117; 0120; 0121, (2020/04/17)

The invention relates to the technical field of polymer oil displacement, and discloses a monomer compound and a preparation method thereof, and a copolymer, a preparation method and applications thereof. The monomer compound provided by the invention has a structure represented by a formula (1), is a temperature-resistant and salt-resistant functional monomer, can improve the tackifying property,the temperature resistance and the salt resistance of a copolymer after being introduced into the copolymer, and can make the copolymer have a certain surface activity so as to be well applied to theoil extraction process of an oil field.

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