66397-25-9Relevant academic research and scientific papers
Novel One-Pot Synthetic Method for Propargyl Alcohol Derivatives from Allyl Alcohol Derivatives
Kutsumura, Noriki,Inagaki, Mai,Kiriseko, Akito,Saito, Takao
, p. 1844 - 1850 (2015/06/30)
An efficient one-pot procedure for the synthesis of propargyl alcohol derivatives from allyl alcohol derivatives has been developed. The key to this transformation from a C-C double bond to a C-C triple bond is that hydrogen bromide elimination from 1,2-dibromoalkanes that contain a neighboring oxygen functional group is promoted by the inductive electron-withdrawing effect of the oxygen functional group. In the one-pot reaction, tetrabutylammonium hydroxide was the best base, and the addition of molecular sieves 13X also promoted the reaction.
Gold(I)-Catalyzed Dearomative [2+2]-Cycloaddition of Indoles with Activated Allenes: A Combined Experimental-Computational Study
Ocello, Riccardo,De Nisi, Assunta,Jia, Minqiang,Yang, Qing-Qing,Monari, Magda,Giacinto, Pietro,Bottoni, Andrea,Miscione, Gian Pietro,Bandini, Marco
supporting information, p. 18445 - 18453 (2015/12/24)
The gold-catalyzed synthesis of methylidene 2,3-cyclobutane-indoles is documented through a combined experimental/computational investigation. Besides optimizing the racemic synthesis of the tricyclic indole compounds, the enantioselective variant is pres
TBAF-promoted dehydrobrominations of vicinal dibromides having an adjacent O-functional group
Kutsumura, Noriki,Kubokawa, Keisuke,Saito, Takao
scheme or table, p. 2717 - 2720 (2010/12/25)
Regioselective HBr elimination of vicinal dibromides having an adjacent oxygen functional group to give the corresponding 2-bromoalk-1-enes was controlled using 1.1 equivalents of TBAF. Two-step elimination to give the corresponding alkynes was controlled using 5.0 equivalents of TBAF. High yield and high selectivity require the presence of an oxygen functional group at the neighboring position of the elimination site.
Site-selective and regioselective Diels-Alder reaction of allenyl aryl ethers
Moghaddam, Firouz Matloubi,Kiamehr, Mostafa
experimental part, p. 1333 - 1337 (2011/09/16)
The site-selectivity and regioselectivity of Diels-Alder reactions of allenyl aryl ethers with cyclopentadiene and acrolein were studied. While cyclopentadiene (as an electron-rich diene) only reacted with the external double bond of allenyl aryl ethers t
Microwave promoted rapid isomerisation of propargyl ethers into allenyl ethers
Moghaddam, Firouz Matloubi,Emami, Rahdar
, p. 4073 - 4077 (2007/10/03)
Aryl or alkyl propargyl ethers have been isomerized efficiently with good to excellent yield into corresponding allenyl ethers in the presence of potassium tert-butoxide under the microwave irradiation.
