6640-59-1

Basic information

• Product Name: 2-(chloromethyl)-4-methyl-3-oxo-3,4-dihydroquinazolin-3-ium
• CAS NO: 6640-59-1
• Molecular Formula: C₁₀H₉ClN₂O
• Molecular Weight: 209.6517
• Mol File: 6640-59-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(chloromethyl)-4-methyl-3-oxo-3,4-dihydroquinazolin-3-ium(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(chloromethyl)-4-methyl-3-oxo-3,4-dihydroquinazolin-3-ium(6640-59-1)
• EPA Substance Registry System: 2-(chloromethyl)-4-methyl-3-oxo-3,4-dihydroquinazolin-3-ium(6640-59-1)

Safety Data

• Hazardous Substances Data: 6640-59-1(Hazardous Substances Data)

Usage

General Description

The chemical 2-(chloromethyl)-4-methyl-3-oxo-3,4-dihydroquinazolin-3-ium (also known as Iodixanol) is a non-ionic, dimeric X-ray contrast agent used in medical imaging. It is a stable, water-soluble compound that is commonly used in computed tomography (CT) scans and angiography procedures to enhance the visibility of blood vessels and soft tissues. Iodixanol works by modifying the density of the fluids it is mixed with, which improves the contrast between different structures in the body. It is well-tolerated by patients and has a lower risk of causing adverse reactions compared to other contrast agents. However, like all contrast agents, Iodixanol carries a risk of allergic reactions and kidney damage, so it should be used with caution particularly in patients with pre-existing kidney problems. Despite these risks, Iodixanol has proven to be a valuable tool in diagnostic imaging and has contributed to numerous medical advancements in the field.

Upstream product

• 4964-49-2 1-(2-aminophenyl)ethanone oxime 
• 79-04-9 chloroacetyl chloride 
• 551-93-9 2-aminoacetophenone 
• 10335-72-5 2-chloro-N-hydroxyacetamide 
• 25384-14-9 2-aminoacetophenone hydrochloride 

Downstream Products

• 668270-12-0 Linagliptin 
• 109113-72-6 2-chloromethyl-4-methylquinazoline 
• 6965-80-6 4-Methyl-2-(4-morpholinylmethyl)-chinazolin-3-oxid 
• 6965-90-8 4-Methyl-2-piperidinomethyl-chinazolin-3-oxid 
• 6965-83-9 2-benzothiazol-2-ylsulfanylmethyl-4-methyl-quinazoline 3-oxide 

Relevant articles and documents

A advantage Ralli sandbank intermediate and its preparation method and application

The present invention relates to a linagliptin intermediate, a preparation method and applications thereof, wherein the linagliptin intermediate has the structure represented by general formulas (II) and (IV), and X is halogen. According to the present invention, the compound of the present invention is the solid and has characteristics of low production cost, easy purification and easy storage, linagliptin can be efficiently prepared, and the method is suitable for industrial scale production.

Mechanism of selective formation of 2-amino-substituted 1,4-benzodiazepin-4-oxides and 2-aminomethyl substituted quinazolin-3-oxides from chloromethyl quinazolin-N-oxides indications from perturbation theory

The o-amino-acetophenone and -benzophenone oximes 1a-c react with chloroacetyl chloride giving the 2-chloromethyl-quinazoline-3-oxides 6a-c. The mechanism is explained using the perturbation theory. With ammonia and N-prim. aliphatic amines, compounds 6a-c yield 1,4-benzodiazepines 16 and 17 as ring-enlarged products, with aromatic and with N-sec. aliphatic amines, quinazoline derivatives 10-13 are formed. The constitution of the heterocycles is proved by nmr spectroscopic methods. Selective formation of the heterocyclic products is explained with the relative thermodynamic stability of the corresponding 2-adducts 14.