6640-59-1

Usage

Uses

Used in Medical Imaging:
2-(chloromethyl)-4-methyl-3-oxo-3,4-dihydroquinazolin-3-ium is used as a contrast agent for improving the visibility of blood vessels and soft tissues in CT scans and angiography procedures. It works by modifying the density of the fluids it is mixed with, which enhances the contrast between different structures in the body.
Used in Diagnostic Imaging:
In the Diagnostic Imaging industry, 2-(chloromethyl)-4-methyl-3-oxo-3,4-dihydroquinazolin-3-ium is used as a contrast agent to aid in the detection and diagnosis of various medical conditions. Its ability to improve the contrast between different structures in the body makes it a valuable tool for radiologists and medical professionals.

Upstream product

• 551-93-9 2-aminoacetophenone 
• 10335-72-5 2-chloro-N-hydroxyacetamide 
• 4964-49-2 1-(2-aminophenyl)ethanone oxime 
• 79-04-9 chloroacetyl chloride 
• 25384-14-9 2-aminoacetophenone hydrochloride 

Downstream Products

• 668270-12-0 Linagliptin 
• 109113-72-6 2-chloromethyl-4-methylquinazoline 
• 6965-90-8 4-Methyl-2-piperidinomethyl-chinazolin-3-oxid 
• 6965-83-9 2-benzothiazol-2-ylsulfanylmethyl-4-methyl-quinazoline 3-oxide 
• 6965-80-6 4-Methyl-2-(4-morpholinylmethyl)-chinazolin-3-oxid 

Relevant academic research and scientific papers

A advantage Ralli sandbank intermediate and its preparation method and application

The present invention relates to a linagliptin intermediate, a preparation method and applications thereof, wherein the linagliptin intermediate has the structure represented by general formulas (II) and (IV), and X is halogen. According to the present invention, the compound of the present invention is the solid and has characteristics of low production cost, easy purification and easy storage, linagliptin can be efficiently prepared, and the method is suitable for industrial scale production.

One-step method for synthesis of 2,4-disubstituted quinazoline 3-oxides by reaction of a 2-aminoaryl ketone with a hydroxamic acid using Zn(OTf) 2 as the catalyst

A simple and efficient method for the preparation of 2,4-disubstituted quinazoline 3-oxides by reaction of a hydroxamic acid with 2-aminoaryl ketones using zinc(II) triflate as the catalyst is described.

Mechanism of selective formation of 2-amino-substituted 1,4-benzodiazepin-4-oxides and 2-aminomethyl substituted quinazolin-3-oxides from chloromethyl quinazolin-N-oxides indications from perturbation theory

The o-amino-acetophenone and -benzophenone oximes 1a-c react with chloroacetyl chloride giving the 2-chloromethyl-quinazoline-3-oxides 6a-c. The mechanism is explained using the perturbation theory. With ammonia and N-prim. aliphatic amines, compounds 6a-c yield 1,4-benzodiazepines 16 and 17 as ring-enlarged products, with aromatic and with N-sec. aliphatic amines, quinazoline derivatives 10-13 are formed. The constitution of the heterocycles is proved by nmr spectroscopic methods. Selective formation of the heterocyclic products is explained with the relative thermodynamic stability of the corresponding 2-adducts 14.

Algicidal and fungicidal 2-haloalkyl-3-oxo-4-substituted quinazoline

2-Haloalkyl-3-oxo-4-substituted quinazolines represented by the formula STR1 wherein R is hydrogen, lower alkyl, lower alkyl substituted with one to three of the same or different halogens, phenyl or phenyl substituted with 1 to 3 of the same or different