664324-19-0

Basic information

• Product Name: 6-Benzothiazolecarboxylic acid, 2-(2-hydroxyphenyl)-
• CAS NO: 664324-19-0
• Molecular Formula: C14H9NO3S
• Molecular Weight: 271.296
• Mol File: 664324-19-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-Benzothiazolecarboxylic acid, 2-(2-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Benzothiazolecarboxylic acid, 2-(2-hydroxyphenyl)-(664324-19-0)
• EPA Substance Registry System: 6-Benzothiazolecarboxylic acid, 2-(2-hydroxyphenyl)-(664324-19-0)

Safety Data

• Hazardous Substances Data: 664324-19-0(Hazardous Substances Data)

Upstream product

• 18330-76-2 2-aminobenzothiazole-6-carboxylic acid hydrochloride 
• 150-13-0 4-amino-benzoic acid 
• 90-02-8 salicylaldehyde 
• 1571-66-0 4-amino-3-mercaptobenzoic acid hydrochloride 
• 69-72-7 salicylic acid 
• 1411685-52-3 C₂₀H₂₄N₂OSSi 
• 16308-11-5 N-(4-cyanophenyl)-2-hydroxybenzamide 
• 873-74-5 4-Aminobenzonitrile 

Downstream Products

• 1411684-96-2 C₁₆H₁₃NO₃S 

Relevant articles and documents

Design, synthesis and evaluation of benzothiazole derivatives as multifunctional agents

Oxidative stress is the product or aetiology of various multifactorial diseases; on the other hand, the development of multifunctional compounds is a recognized strategy for the control of complex diseases. To this end, a series of benzothiazole derivatives was synthesized and evaluated for their multifunctional effectiveness as antioxidant, sunscreen (filter), antifungal and antiproliferative agents. Compounds were easily synthesized via condensation reaction between 2-aminothiophenols and different benzaldehydes. SAR study, particularly in position 2 and 6 of benzothiazoles, led to the identification of 4g and 4k as very interesting potential compounds for the design of multifunctional drugs. In particular, compound 4g is the best blocker of hERG potassium channels expressed in HEK 293 cells exhibiting 60.32percent inhibition with IC50 = 4.79 μM.