66502-11-2

Upstream product

• 3282-32-4 2-diazo-acetophenone 
• 75-33-2 2-propanethiol 
• 70-11-1 α-bromoacetophenone 
• 532-27-4 1-chloroacetophenone 

Downstream Products

• 121045-44-1 3-(2-Acetoxy-1-isopropylsulfanyl-2-phenyl-ethyl)-4-hydroxy-benzoic acid ethyl ester 
• 121045-26-9 ethyl 2,3-dihydro-3-isopropylthio-2-phenyl-1-benzofuran-5-carboxylate 
• 121045-42-9 2-methoxyethyl 2-phenyl-1-benzofuran-5-carboxylate 
• 121045-39-4 5-methyl-2-phenylbenzofuran 
• 121045-19-0 2-isopropylthio-1-(2-methoxyethoxy)-1-phenylethane 
• 121045-17-8 1-acetoxy-1-phenyl-2-isopropylthioethane 
• 121045-40-7 2-phenyl-1-benzofuran-5-carbaldehyde 
• 14385-51-4 7-methoxy-2-phenylbenzo[b]furan 
• 7182-32-3 2-phenyl-5-methoxybenzo[b]furan 
• 50543-55-0 7-methyl-2-phenylbenzofuran 
• 18761-36-9 5-chloro-2-phenylbenzofuran 
• 25871-52-7 5-methyl-2-phenylbenzofuran 

Relevant academic research and scientific papers

Highly chemoselective α-diazo carbonyl insertion reactions into N-H and S-H bonds catalysed by [RuCl(η5-C5H5)(PPh3)2]

Complex [RuCl(η5-C5H5)(PPh3)2], in chloroform at 60 deg C, catalyses the chemoselective insertion of α-diazo carbonyl compounds into N-H and S-H bonds to afford α-keto-amines and α-keto-thioethers.

Ylidions: A New Reactive Intermediate Prepared by Photosensitized One-Electron Oxidation of Phenacyl Sulfonium Ylides

The chemistry of a series of phenacyl sulfonium ylides was studied.Their photosensitized one-electron oxidation by 9,10-dicyanoanthracene generates ylidions, a new class of radical cation intermediates.In some cases, the ylidions cleave to form a free alkyl radical and a cation; in others, they are attacked by nucleophiles or by an alkene.The chemical properties displayed by the phenacyl sulfonium ylidions appear to be controlled primarily by the nature of the sulfur-bound alkyl groups.The direct photolysis and thermolysis of the phenacyl sulfonium ylides was examined for comparison with their one-electron oxidation.Some of the ylides undergo the Stevens rearrangement either when heated or photolyzed.Contrary to an earlier report, there is no evidence that direct photolysis of a phenacyl sulfonium ylide leads to formation of benzoylcarbene.

SELECTIVE PREPARATION AND CYCLIZATION OF 2-(2-HYDROXYPHENYL)-2-(ISOPROPYLTHIO)ETHANOLS. NEW SYNTHESIS OF 1-BENZOFURANS

Reaction of phenols with 2-(isopropylthio)ethyl acetate activated by sulphuryl chloride afforded 2-phenols regioselectively, via sigmatropic rearrangement of phenoxysulphonium ylides.The ortho-alkylated phenols thus obtained have been cyclized with conc. hydrochloric acid in 2-methoxyethanol to 1-benzofurans. 2-Methyl- and 2-phenyl-1-benzofurans have been prepared similarly.

Hydantoin derivatives as potential antiinflammatory agents

The hydantoins 2a-c and three hydantoic acids were synthesized and their anti-inflammatory properties were determined in the rat paw oedema test. Neither 1-phenyl-sulphonyl-5,5-diphenylhydantoin, which has been described as an inflammatory, nor any of the other compounds, showed significant anti-inflammatory activity.