7182-32-3

Basic information

• Product Name: Benzofuran, 5-methoxy-2-phenyl-
• CAS NO: 7182-32-3
• Molecular Formula: C15H12O2
• Molecular Weight: 224.259
• Mol File: 7182-32-3.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: Benzofuran, 5-methoxy-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzofuran, 5-methoxy-2-phenyl-(7182-32-3)
• EPA Substance Registry System: Benzofuran, 5-methoxy-2-phenyl-(7182-32-3)

Safety Data

• Hazardous Substances Data: 7182-32-3(Hazardous Substances Data)

Upstream product

• 14385-49-0 8-(4'-methoxyphenoxy)acetophenone 
• 85630-18-8 N,N-diethyl-O-(4-methoxyphenyl)carbamate 
• 28995-88-2 1-methyl-4-((phenylethynyl)sulfonyl)benzene 
• 13391-28-1 5-methoxybenzofuran 
• 591-50-4 iodobenzene 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 108-86-1 bromobenzene 
• 13391-30-5 2,3-dihydro-5-methoxybenzofuran 
• 144828-84-2 N-methoxy-1′-(3-methoxyphenyl)-N-methylacetamide 
• 100-42-5 styrene 
• 150-76-5 4-methoxy-phenol 
• 69034-13-5 p-methoxyphenoxyacetaldehyde diethyl acetal 
• 114-83-0 1-acetyl-2-phenylhydrazine 

Downstream Products

• 1025330-18-0 (S)-5-methoxy-2-phenyl-2,3-dihydrobenzofuran 
• 7182-29-8 5-hydroxy-2-phenylbenzofuran 

Relevant articles and documents

Transition Metal-Free Synthesis of Halobenzo[b]furans from O-Aryl Carbamates via o-Lithiation Reactions

A straightforward and transition metal-free one-pot protocol to synthesize halobenzo[b]furans has been developed employing simple and easily available starting materials such as O-aryl carbamates and alkynylsulfones. The fine-tuning of the different steps involved was key to achieving a successful one-pot procedure. Initially, a directed ortho-lithiation process, which uses the carbamate as the directed metalation group, was crucial in providing access to O-2-alkynylaryl N,N-diethyl carbamates by a direct alkynylation of the o-lithiated carbamate, with arylsulfonylalkynes as electrophilic reagents. Cyclization of the generated o-alkynylaryl carbamates was successfully accomplished through a strategy involving in situ carbamate alkaline hydrolysis under conventional heating or microwave irradiation, coupled with a subsequent heterocyclization step delivering the desired benzo[b]furans. A wide variety of new halobenzo[b]furans has been synthesized and their utility has been demonstrated by their further transformation.

Synthesis and biological evaluation of 2-arylbenzofuran derivatives as potential anti-Alzheimer’s disease agents

Alzheimer's disease (AD) is a type of progressive dementia caused by degeneration of the nervous system. A single target drug usually does not work well. Therefore, multi-target drugs are designed and developed so that one drug can specifically bind to mu

Synthesis of Benzo[ b]furans by Intramolecular C-O Bond Formation Using Iron and Copper Catalysis

One-pot processes for the synthesis of benzo[b]furans from 1-aryl- or 1-alkylketones using nonprecious transition metal catalysts have been developed. Regioselective iron(III)-catalyzed halogenation of the aryl ring, followed by iron- or copper-catalyzed O-arylation allowed the synthesis of various structural analogues, including the benzo[b]furan-derived natural products corsifuran C, moracin F, and caleprunin B.