66521-54-8

Basic information

• Product Name: 3-(DIMETHYLAMINO)-1-(2-PYRIDYL)-2-PROPE&
• Synonyms: 3-(DIMETHYLAMINO)-1-(2-PYRIDYL)-2-PROPE&;(E)-3-DiMethylaMino-1-(2-pyridyl)-2-propen-1-one, 98%;2-[3-(Dimethylamino)acryloyl]pyridine;3-(Dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one;3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one 95%;(2E)-3-(dimethylamino)-1-pyridin-2-ylprop-2-en-1-one;(E)-3-dimethylamino-1-(2-pyridyl)prop-2-en-1-one;1-(2-Pyridyl)-3-dimethylamino-2-propen-1-one
• CAS NO: 66521-54-8
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.218
• Product Categories: C9 to C46;Heterocyclic Building Blocks;Pyridines
• Mol File: 66521-54-8.mol
• Article Data: 64

Chemical Properties

• Melting Point: 126-130 °C(lit.)
• Boiling Point: 281.4 °C at 760 mmHg
• Flash Point: 124 °C
• Appearance: /
• Density: 1.07
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.25±0.70(Predicted)
• CAS DataBase Reference: 3-(DIMETHYLAMINO)-1-(2-PYRIDYL)-2-PROPE&(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(DIMETHYLAMINO)-1-(2-PYRIDYL)-2-PROPE&(66521-54-8)
• EPA Substance Registry System: 3-(DIMETHYLAMINO)-1-(2-PYRIDYL)-2-PROPE&(66521-54-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 66521-54-8(Hazardous Substances Data)

Usage

Synthesis

3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one was synthesised based on the literature. The reaction of (2g, 16.5mmol) of 2-acetylpyridine and DMF dimethyl acetal(7.84g) were suspended in 11ml of xylene and stir this reaction mixture for 16h at 110℃. Into the resulting mixture 10 ml of hexane added yellow colour precipitate was formed and allows stirring for 20min at 3℃. Resulting mixture was filtered and dried in vacuum to get a yellow colour powder.

Uses

3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one may be used in the preparation of the 5-(heteroaryl)isoxazole derivatives, 5-(2-pyridyl)isoxazole and 3-methyl-5-(2-pyridyl)isoxazole. It may also be used to synthesize 7-(2-pyridyl)-1,2,4-triazolo[1,5-a]pyrimidine.

General Description

3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one (1-(2′-Pyridyl)-3-dimethylamino-2-propen-1-one), an enaminone, is a hemilabile hybrid ligand. The preparation of cationic mononuclear rhodium(I) or iridium(I) complexes containing 3-(dimethylamino)-1-(2-pyridyl)-2-propen-1-one have been reported.

Upstream product

• 1122-62-9 2-acetylpyridine 
• 127-19-5 N,N-dimethyl acetamide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 98-86-2 acetophenone 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 25408-61-1 Ν,Ν-dimethylacetamide dimethyl acetal 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 66521-65-1 4-(pyridin-2-yl)pyrimidine-2-ylamine 
• 1458040-92-0 2-((S)-1-phenylethylamino)-4-(pyridin-2-yl)pyrimidine 
• 1458040-93-1 2-((R)-1-phenylethylamino)-4-(pyridin-2-yl)pyrimidine 
• 52997-82-7 4-(pyridin-2-yl)pyrimidine 
• 25194-63-2 2-methyl-4-(2-pyridyl)pyrimidine 
• 866000-20-6 4-[(4-pyridin-2-yl-pyrimidin-2-ylamino)-methyl]-benzoic acid 
• 78562-50-2 ethyl 7-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 320417-17-2 7-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 75415-03-1 2-(1H-pyrazol-3-yl)pyridine 
• 138785-70-3 (+)-2-<1-(1-Phenylethyl)-5-pyrazolyl>pyridin 
• 35299-71-9 2,6-bis(thiophen-2-yl)pyridine 

Relevant articles and documents

Method for large-scale production α, α, α .

The invention discloses a method for large-scale production α, α, α . The reaction operation in Step a was as follows: At room temperature 2 - acetyl pyridine was added. Then N mL of N -dimethyl formamide dimethyl acetal and a catalyst are added to the organic solvent, and after the reaction is completed, the reaction solution is poured into an aqueous sodium hydroxide solution, and then the resulting organic phase is washed, dried, concentrated and recrystallized to obtain an intermediate: 1 - (3 - pyridyl) -3 - (dimethylamino) -2 - propylene -1 - ketone. The method disclosed by the invention is easy to implement large-scale production, high in yield, low in cost, simple to operate and mild in reaction condition.

A family of polyoxometalate-resorcin[4]arene-based metal–organic materials: Assemblies, structures and lithium ion battery properties

Polyoxometalates (POMs) are alternative anode materials of lithium ion batteries (LIBs) for their reversible electrochemical redox behaviors and electron storage functions. To overcome the low conductivity and poor stability of the POMs, embedment of POMs into metal–organic hybrid complexes is a promising synthetic strategy. Here, we designed a family of copper-containing POM-resorcin[4]arene-based complexes supported by a resorcin[4]arene ligand (TPTR4A), copper cations and Keggin-type POMs, namely, [Cu4(TPTR4A)2][PMo12O40](OH)·2DMA·H2O (1a), [Cu4(TPTR4A)2][SiW12O40]·2.5DMA (1b) and [Cu4(TPTR4A)2][PW12O40](OH)·0.5DMA·5H2O (1c) (DMA = N,N’-dimethylacetamide). To improve the conductivity of the complexes, composites 1a@GO-1c@GO were obtained through mechanical grinding of the complexes and graphene oxide (GO). Strikingly, they show high initial specific capacity and stability for LIBs. This work offered a strategy for application of the POM-based complexes as LIBs via combining POM-based complexes and RGO.

Stereoselective synthesis of trifluoromethyl-substituted 2: H -furan-amines from enaminones

A straightforward strategy for synthesis of highly functionalized trifluoromethyl 2H-furans is described. The copper catalyzed method relies on a cascade cyclic reaction between enaminones and N-tosylhydrazones. This method allows the synthesis of 2-amino