66548-50-3

Usage

Uses

Used in Scientific Research:
3-(4-Bromophenyl)-6-chloropyridazine is used as a research compound for exploring its chemical properties and potential applications in various scientific fields. Its unique structure with both bromine and chlorine atoms allows for diverse reactions and interactions with other compounds.
Used in Medical Research:
In the medical field, 3-(4-Bromophenyl)-6-chloropyridazine may be used as a starting material for the synthesis of pharmaceutical compounds or as a tool in drug discovery processes. Its specific interactions with biological systems can provide insights into the development of new therapeutic agents.
Used in Industrial Applications:
3-(4-Bromophenyl)-6-chloropyridazine may also find use in various industrial applications, such as the production of specialty chemicals, materials, or intermediates for further chemical reactions. Its versatility and reactivity can contribute to the development of new products and processes.

Upstream product

• 36725-37-8 6-(4-bromophenyl)-4,5-dihydropyridazin-3(2H)-one 
• 99-90-1 para-bromoacetophenone 
• 6340-79-0 4-oxo-4-(4-bromophenyl)butanoic acid 
• 108-86-1 bromobenzene 
• 50636-57-2 6-(4-bromophenyl)-3(2H)-pyridazin-3-one 
• 316174-45-5 4-(p-bromophenyl)-4-oxo-2-(4-antipyrinyl)butanoic acid 
• 20972-38-7 (E)-4-(4-bromophenyl)-4-oxobut-2-enoic acid 
• 316174-47-7 6-(p-bromophenyl)-4-(4-anitpyrinyl)-4,5-dihydropyridazin-3(2H)-one 

Downstream Products

• 53346-62-6 3-(4-bromophenyl)-6-hydrazinopyridazine 
• 956150-95-1 3-phenyl-6-(4'-bromophenyl)-1,2,4-triazolo[4,3-b]pyridazine 
• 1268133-96-5 3-(4'-tolyl)-6-(4'-bromophenyl)-1,2,4-triazolo[4,3-b]pyridazine 
• 67820-95-5 N'-(6-phenyl-pyridazin-3-yl)-hydrazinecarboxylic acid ethyl ester 
• 67820-76-2 N'-[6-(4-bromo-phenyl)-pyridazin-3-yl]-hydrazinecarboxylic acid ethyl ester 
• 66129-24-6 6-(4-bromo-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine 
• 855738-48-6 (3R)-3-[6-(4-bromo-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane 

Relevant academic research and scientific papers

Synthesis and Bioevaluation of 3,6-Diaryl-[1,2,4]triazolo[4,3-b] Pyridazines as Antitubulin Agents

A series of 3,6-diaryl-[1,2,4]triazolo[4,3-b]pyridazines were designed as a class of vinylogous CA-4 analogues. The easily isomerized (Z,E)-butadiene linker of vinylogous CA-4 was replaced by a rigid [1,2,4]triazolo[4,3-b]pyridazine scaffold. Twenty-one target compounds were synthesized and exhibited moderate to potent antiproliferative activity. The compound 4q with a 3-amino-4-methoxyphenyl moiety as the B-ring, comparable to CA-4 (IC50 = 0.009-0.012 μM), displayed the highly active antiproliferative activity against SGC-7901, A549, and HT-1080 cell lines with IC50 values of 0.014, 0.008, and 0.012 μM, respectively. Tubulin polymerization experiments indicated that 4q effectively inhibited tubulin polymerization, and immunostaining assay revealed that 4q significantly disrupted tubulin microtubule dynamics. Moreover, cell cycle studies revealed that compound 4q dramatically arrested cell cycle progression at G2/M phase in A549 cells. Molecular modeling studies showed that 4q could bind to the colchicine binding site on microtubules.

Synthesis of some new pyridazin-3-one derivatives and their utility in heterocyclic synthesis

(Chemical Equation Presented) Synthesis of new heterocyclic compounds containing the pyridazinone moiety, which have a valuable biological activities, has been achieved through the nucleophilic addition of benzylamine to 4-(p-substituted phenyl)-4-oxo-2-b

FUSED BICYCLOHETEROCYCLE SUBSTITUTED QUINUCLIDINE DERIVATIVES

Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N+-O-; X is O, S, -NH-, and -N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by a7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

Fused bicycloheterocycle substituted quinuclidine derivatives

Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N+—O—; X is O, S, —NH—, and —N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

Substituted diazabicycloalkane derivatives

Compounds of formula (I) [in-line-formulae]Z-Ar1—Ar2??(I) [/in-line-formulae] wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

3-Quinuclidinyl amino-substituted biaryl derivatives

Compounds of formula (I) wherein A is N or N+—O?; n is 0, 1, or 2; Y is O, S, —NH—, and —N-alkyl-; Ar1 is both 6-membered aromatic rings; Ar2 is 5- or 6-membered aromatic rings with a —NR8R9 group, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

Synthesis and Reactions of 4-(p-Bromophenyl)-4-oxo-2-(4-antipyrinyl)-butanoic Acid and Some Unexpected Products

Reaction of antipyrin with 4-oxo-4-(p-bromophenyl)-2-butenoic acid gave the butanoic acid derivative 3. Reaction of 3 with o-phenylenediamine in presence of hydrochloric acid gave the unexpected condensation with dearylation product 4. Reaction of 3 with hydrazines gave the pyridazinone derivatives 5 and 7. Reaction of 5 with phosphoryl chloride gave the unexpected product 6-(p-bromophenyl)-3-chloropyridazine 8. The reactions of 5 with formaldehyde-piperidine, ethyl chloroacetate, acetyl chloride, acrylonitrile and chloroacetic acid gave the N-substituted products. The behaviour of compound 8 toward each of hydrazine hydrate, sodium azide, anthranilic acid, acid hydrazides and sulfa derivatives was also studied. Mechanisms for the reactions have been proposed.

Hypotensive alkyl-3-[6-(aryl)-3-pyridazinyl]-carbazates

This disclosure describes novel alkyl 3-[6-(aryl)-3-pyridazinyl]-carbazates useful as hypotensive agents in mammals. SP CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of our copending application Ser. No. 692,254, filed June 3, 1976 now abandoned, which in turn is a continuation-in-part of our abandoned application Ser. No. 552,024, filed Feb. 24, 1975 now abandoned.