66548-50-3

Basic information

• Product Name: 3-(4-BROMOPHENYL)-6-CHLOROPYRIDAZINE
• Synonyms: 3-(4-BROMOPHENYL)-6-CHLOROPYRIDAZINE
• CAS NO: 66548-50-3
• Molecular Formula: C₁₀H₆BrClN₂
• Molecular Weight: 269.53
• Mol File: 66548-50-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 421.6 °C at 760 mmHg
• Flash Point: 208.8 °C
• Appearance: /
• Density: 1.591 g/cm³
• CAS DataBase Reference: 3-(4-BROMOPHENYL)-6-CHLOROPYRIDAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-BROMOPHENYL)-6-CHLOROPYRIDAZINE(66548-50-3)
• EPA Substance Registry System: 3-(4-BROMOPHENYL)-6-CHLOROPYRIDAZINE(66548-50-3)

Safety Data

• Hazardous Substances Data: 66548-50-3(Hazardous Substances Data)

Usage

General Description

3-(4-Bromophenyl)-6-chloropyridazine is a synthetic, organic chemical compound that belongs to the group of halocarbons. This aromatic halide features both bromine and chlorine atoms, positioned on a phenyl ring and a pyridazine ring respectively. Often used in research and development settings, its precise properties can vary depending on its environment and the specific reactions it undergoes. Like many synthetic chemical compounds, its health and environmental impacts are potentially significant, therefore proper handling and disposal measures must be implemented to prevent harm. The potential applications of this chemical compound are likely to be broad, as it may be applicable in various scientific, medical, or industrial contexts. Specific details about its safety, toxicity, and handling requirements should be sought from its Material Safety Data Sheet (MSDS).

Upstream product

• 316174-47-7 6-(p-bromophenyl)-4-(4-anitpyrinyl)-4,5-dihydropyridazin-3(2H)-one 
• 99-90-1 para-bromoacetophenone 
• 6340-79-0 4-oxo-4-(4-bromophenyl)butanoic acid 
• 108-86-1 bromobenzene 
• 50636-57-2 6-(4-bromophenyl)-3(2H)-pyridazin-3-one 
• 316174-45-5 4-(p-bromophenyl)-4-oxo-2-(4-antipyrinyl)butanoic acid 
• 20972-38-7 (E)-4-(4-bromophenyl)-4-oxobut-2-enoic acid 
• 36725-37-8 6-(4-bromophenyl)-4,5-dihydropyridazin-3(2H)-one 

Downstream Products

• 66129-24-6 6-(4-bromo-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine 
• 956150-95-1 3-phenyl-6-(4'-bromophenyl)-1,2,4-triazolo[4,3-b]pyridazine 
• 1268133-96-5 3-(4'-tolyl)-6-(4'-bromophenyl)-1,2,4-triazolo[4,3-b]pyridazine 
• 67820-95-5 N'-(6-phenyl-pyridazin-3-yl)-hydrazinecarboxylic acid ethyl ester 
• 67820-76-2 N'-[6-(4-bromo-phenyl)-pyridazin-3-yl]-hydrazinecarboxylic acid ethyl ester 
• 855738-48-6 (3R)-3-[6-(4-bromo-phenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane 
• 53346-62-6 3-(4-bromophenyl)-6-hydrazinopyridazine 

Relevant articles and documents

Synthesis and Bioevaluation of 3,6-Diaryl-[1,2,4]triazolo[4,3-b] Pyridazines as Antitubulin Agents

A series of 3,6-diaryl-[1,2,4]triazolo[4,3-b]pyridazines were designed as a class of vinylogous CA-4 analogues. The easily isomerized (Z,E)-butadiene linker of vinylogous CA-4 was replaced by a rigid [1,2,4]triazolo[4,3-b]pyridazine scaffold. Twenty-one target compounds were synthesized and exhibited moderate to potent antiproliferative activity. The compound 4q with a 3-amino-4-methoxyphenyl moiety as the B-ring, comparable to CA-4 (IC50 = 0.009-0.012 μM), displayed the highly active antiproliferative activity against SGC-7901, A549, and HT-1080 cell lines with IC50 values of 0.014, 0.008, and 0.012 μM, respectively. Tubulin polymerization experiments indicated that 4q effectively inhibited tubulin polymerization, and immunostaining assay revealed that 4q significantly disrupted tubulin microtubule dynamics. Moreover, cell cycle studies revealed that compound 4q dramatically arrested cell cycle progression at G2/M phase in A549 cells. Molecular modeling studies showed that 4q could bind to the colchicine binding site on microtubules.

Synthesis of some new pyridazin-3-one derivatives and their utility in heterocyclic synthesis

(Chemical Equation Presented) Synthesis of new heterocyclic compounds containing the pyridazinone moiety, which have a valuable biological activities, has been achieved through the nucleophilic addition of benzylamine to 4-(p-substituted phenyl)-4-oxo-2-b

Substituted diazabicycloalkane derivatives

Compounds of formula (I) [in-line-formulae]Z-Ar1—Ar2??(I) [/in-line-formulae] wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.