6662-53-9

Basic information

• Product Name: (2E)-N-(3,4-DICHLOROPHENYL)-2-(HYDROXYIMINO)ACETAMIDE
• Synonyms: (2E)-N-(3,4-dichlorophenyl)-2-(hydroxyimino)acetamide
• CAS NO: 6662-53-9
• Molecular Formula: C₈H₆Cl₂N₂O₂
• Molecular Weight: 233.0514
• Mol File: 6662-53-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.49g/cm³
• Refractive Index: 1.609
• CAS DataBase Reference: (2E)-N-(3,4-DICHLOROPHENYL)-2-(HYDROXYIMINO)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-N-(3,4-DICHLOROPHENYL)-2-(HYDROXYIMINO)ACETAMIDE(6662-53-9)
• EPA Substance Registry System: (2E)-N-(3,4-DICHLOROPHENYL)-2-(HYDROXYIMINO)ACETAMIDE(6662-53-9)

Safety Data

• Hazardous Substances Data: 6662-53-9(Hazardous Substances Data)

Usage

General Description

(2E)-N-(3,4-Dichlorophenyl)-2-(hydroxyimino)acetamide is a chemical compound with the molecular formula C10H8Cl2N2O2. It is a derivative of acetamide and contains a hydroxyimino group and a dichlorophenyl group. (2E)-N-(3,4-DICHLOROPHENYL)-2-(HYDROXYIMINO)ACETAMIDE is a potent herbicide and is used to control a wide range of weeds and grasses in various crops. It works by inhibiting the growth of weeds by disrupting their metabolic processes, ultimately leading to their death. It is important to handle this chemical with care, as it can be toxic to humans and the environment if not used properly. Additionally, it is important to follow safety guidelines when working with (2E)-N-(3,4-dichlorophenyl)-2-(hydroxyimino)acetamide to minimize the risk of exposure.

InChI:InChI=1/C8H6Cl2N2O2/c9-6-2-1-5(3-7(6)10)12-8(13)4-11-14/h1-4,14H,(H,12,13)/b11-4+

Upstream product

• 75-87-6 chloral 
• 95-76-1 m,p-dichloroaniline 
• 302-17-0 chloral hydrate 

Downstream Products

• 857601-95-7 6-(carboxymethyl-amino)-2,3-dichloro-benzoic acid 
• 113525-09-0 2-(carboxymethyl-amino)-4,5-dichloro-benzoic acid 
• 20776-61-8 2-amino-4,5-dichloro-benzoic acid 
• 20776-60-7 6-amino-2,3-dichlorobenzoic acid 
• 1677-48-1 5,6-dichloroisatin 
• 1677-47-0 4,5-Dichloro-1H-indole-2,3-dione 

Relevant articles and documents

Synthesis of substituted tryptanthrin via aryl halides and amines as antitumor and anti-MRSA agents

The natural alkaloid, tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), and its analogues are found to exhibit potent antitumor and anti-MRSA activities. An efficient and convenient method has been developed for the synthesis of tryptanthrin D-ring derivatives through the reaction of substituted tryptanthrins and secondary amines in moderate to good yields. Some of the new compounds exhibited antitumor activities against the human tumor cell lines A549, HCT116 and MDA-MB-231, with mean IC50 values at low micromolar levels. In addition, some of the compounds showed excellent anti-MRSA activities and were more effective than vancomycin, with MIC values of 0.31–1.25 μg/mL for Mu50,RN4220, and Newman strains.

Synthesis and antifungal activity of 1-aminomethyl-3-{4- (chlorobenzyloxy) benzoylhydrazono}-4, 5/5, 6-dichloroindolin-2- ones

3-{4-(Chlorobenzyloxy) benzoylhydrazono}-4,5/5,6-dichloroindolin-2-ones 1a,b-5a,b, were synthesized by the condensation of 4-(chlorobenzyloxy) benzoylhydrazines and 4, 5/5, 6-dichloroindolin-2,3-diones. Compounds 1a,b-5a,b when subjected to Mannich reaction with secondary heterocyclic amines in the presence of formaldehyde, furnished 1-aminomethyl-3-{4-(chlorobenzyloxy) benzoylhydrazono}-4, 5/5, 6-dichloroindolin-2- ones 6a,b-20a,b. The structures of the compounds have been established by means of spectral (IR and 1H NMR) and elemental analysis. The compounds have been screened for their antifungal potential against human pathogenic fungi.

Biological activities and quantitative structure-activity relationships of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as aldose reductase inhibitors

A series of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones were prepared and tested for aldose reductase inhibitory activity. The 6'- halogenated derivatives were found to be highly potent in vitro inhibitors of male rabbit lens aldose reductase and in vivo inhibitors of polyol accumulation in the sciatic nerves of galactosemic rats. Of these, (4R)-6'- chloro-3'-methylspiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-trione (67) showed the most potent in vitro and in vivo activities. An oral dose of 3 g/kg of compound 67 caused neither death nor behavioral abnormality in the preliminary acute toxicity study using mice and rats. Compound 67 was selected as a candidate for further evaluation. The quantitative structure- activity relationships in this series are also discussed.