66696-94-4Relevant academic research and scientific papers
Structure-Activity Relationship Study of Majusculamides A and B and Their Analogues on Osteogenic Activity
Nakajima, Daisuke,Natsume, Noriyuki,Ozaki, Kaori,Teruya, Toshiaki,Yokoshima, Satoshi
supporting information, p. 2477 - 2482 (2020/10/02)
We discovered that majusculamide A (1) and majusculamide B (2), isolated from a marine cyanobacterium collected in Okinawa, induced osteoblast differentiation in MC3T3-E1 cells. Although majusculamide A (1) has a different configuration only at the C-19 stereocenter, bearing a methyl group, compared to majusculamide B (2), the effect of 1 was stronger than that of 2. We synthesized some analogues of the majusculamides (3-15) and evaluated osteogenic activities of these analogues. The structure-activity relationship study of majusculamide analogues suggested that the number of methyls and configuration at C-19 and the nature of the substituent at C-20 of majusculamide A (1) may be important for the osteoblast differentiation-inducing effect of 1.
Synthesis and Characterization of Four Diastereomers of Monorhamnolipids
Palos Pacheco, Ricardo,Eismin, Ryan J.,Coss, Clifford S.,Wang, Hui,Maier, Raina M.,Polt, Robin,Pemberton, Jeanne E.
supporting information, p. 5125 - 5132 (2017/05/04)
Rhamnolipids are amphiphilic glycolipids biosynthesized by bacteria that, due to their low toxicity and biodegradability, are potential replacements for synthetic surfactants. The previously limited access to pure materials at the gram scale has hindered
