667-50-5

Upstream product

• 111-70-6 n-heptan1ol 
• 1550-50-1 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine 
• 27871-49-4 (S)-Methyl lactate 
• 4341-24-6 5-methylcyclohexan-1,3-dione 
• 97-64-3 ethyl 2-hydroxypropionate 
• 547-64-8 methyl lactate 
• 126-81-8 dimedone 
• 504-02-9 1,3-cylohexanedione 

Downstream Products

• 352-24-9 ethyl 4,4-difluoro-3-oxobutyrate 
• 89129-66-8 4,4-difluoro-3-oxo-butanoic acid methyl ester 
• 1550-50-1 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine 
• 1271473-84-7 2,2-difluoro-1-(3-methoxyphenyl)ethan-1-one 
• 454-31-9 ethyl difluoroacetate 
• 81170-29-8 2,2-difluoro-1-[4-(methylsulfanyl)phenyl]ethanone 
• 114829-07-1 ω,ω-Difluoro-4-methoxyacetophenone 

Relevant academic research and scientific papers

Method for co-producing 2-fluoropropionate and ethyl difluoroacetate

The invention discloses a method for co-producing 2-fluoropropionate and ethyl difluoroacetate. The method comprises: (a) carrying out a reaction on a fluorinating reagent and a lactate for 0.5-7 h ata reaction temperature of 30-120 DEG C according to a molar ratio of 0.5-2:1, cooling the reaction material after completing the reaction, adding a nitrogen-containing compound, and carrying out pressure reducing rectification to obtain a 2-fluoropropionate product and N,N-dimethyl difluoroacetamide; and (b) adding concentrated sulfuric acid to a mixture of anhydrous ethanol and the N,N-dimethyldifluoroacetamide obtained in the step (a), carrying out a reaction for 1-10 h at a reaction temperature of 50-170 DEG C, cooling after completing the reaction, separating the liquid, and carrying outrectification to obtain the ethyl difluoroacetate product, wherein a molar ratio of anhydrous ethanol to N,N-dimethyl difluoroacetamide is 0.5-4.5:1, and a molar ratio of concentrated sulfuric acid to N,N-dimethyl difluoroacetamide is 0.1-1.5:1. According to the present invention, the method has advantages of environmental protection, high yield and low cost.

Reactions of 1,1,2,2-tetrafluoroethyl-N,N-dimethylamine with linear and cyclic 1,3-diketones

Ketones are known to be unreactive toward α-fluoroamines such as Ishikawa's Reagent or 1,1,2,2-tetrafluoroethyl-N,N-dimethylamine (TFEDMA). On the other hand, 1,3-diketones were found to undergo fluorination with TFEDMA. In the case of linear 1,3-diketone

STEREOSELECTIVE ONE STEP FLUORINATION PROCESS FOR THE PREPARATION OF 2-FLUOROPROPIONATE

The current invention describes a one-step process for the synthesis of 2-fluoropropionates from lactic acid ester derivatives using TFEDMA.

1,1,2,2-Tetrafluoroethyl-N,N-dimethylamine: A new selective fluorinating agent

The title compound has been prepared in 96-98% yield by the reaction of tetrafluoroethylene and dimethylamine. 1,1,2,2-Tetrafluoroethyl-N,N-dimethylamine (1) is found to be an effective reagent for the conversion of alcohols into alkyl fluorides. Reaction of 1 and primary alcohols proceeds with high yield formation of the corresponding alkyl fluorides at elevated temperature. However, the reaction of secondary and tertiary alcohols rapidly takes place at 0-10°C, producing corresponding alkyl fluorides as major product along with some olefins.