6673-14-9

Usage

Uses

Used in Organic Chemistry and Materials Science:
1,5-BIS(4-DIMETHYLAMINOPHENYL)-1,4-PENTADIEN-3-ONE is used as a fluorescent probe for its ability to provide insights into the properties and behaviors of various organic compounds and materials. Its fluorescent properties allow for the tracking and analysis of molecular interactions and transformations.
Used in Sensor Development:
1,5-BIS(4-DIMETHYLAMINOPHENYL)-1,4-PENTADIEN-3-ONE is used as a component in the development of sensors due to its responsive optical properties, which can change in the presence of specific analytes, making it a valuable indicator in detecting and measuring various substances.
Used in Imaging Agents:
In the field of imaging, 1,5-BIS(4-DIMETHYLAMINOPHENYL)-1,4-PENTADIEN-3-ONE is used as a component of imaging agents, capitalizing on its fluorescent properties to enhance the visualization of biological structures and processes in medical and biological research.
Used in OLED Material Development:
1,5-BIS(4-DIMETHYLAMINOPHENYL)-1,4-PENTADIEN-3-ONE is utilized in the development of OLED (Organic Light Emitting Diode) materials, where its fluorescent characteristics contribute to the creation of efficient and vibrant light-emitting devices.
Used in Biotechnology:
1,5-BIS(4-DIMETHYLAMINOPHENYL)-1,4-PENTADIEN-3-ONE is used in biotechnology as a fluorescent label for biomolecules, enabling researchers to track and visualize the behavior of these molecules within complex biological systems.
Used in Molecular Biology Research:
As a tool for studying biological processes at the molecular level, 1,5-BIS(4-DIMETHYLAMINOPHENYL)-1,4-PENTADIEN-3-ONE aids researchers in understanding intricate molecular interactions and dynamics, contributing to advancements in the life sciences.

InChI:InChI=1/C21H24N2O/c1-22(2)19-11-5-17(6-12-19)9-15-21(24)16-10-18-7-13-20(14-8-18)23(3)4/h5-16H,1-4H3/b15-9+,16-10+

Upstream product

• 5432-53-1 4-p-dimethylaminophenyl-3-buten-2-one 
• 112-02-7 cetyltrimethylammonium chloride 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 67-64-1 acetone 

Downstream Products

• 122252-46-4 bis (4-p-dimethylaminophenyl-2-pytazolin-3-yl) ketone 
• 3418-96-0 1,5-Bis-<4-dimethylamino-phenyl>-pentadien-(1,3) 
• 202471-52-1 2,6-Bis-(4-dimethylamino-phenyl)-4-oxo-cyclohexane-1,1-dicarboxylic acid dimethyl ester 
• 210429-20-2 6,10-Bis-(4-dimethylamino-phenyl)-2-oxa-3-aza-spiro[4.5]decane-1,4,8-trione 
• 210429-18-8 6,10-Bis-(4-dimethylamino-phenyl)-2,3-diaza-spiro[4.5]decane-1,4,8-trione 
• 210429-43-9 C₂₅H₃₀N₆O₄ 
• 210429-29-1 C₂₅H₃₁N₇O₃ 
• 114563-77-8 C₃₀H₃₁N₃ 
• 2564-18-3 1-phenyl-3-((dimethylamino)styryl)-5-((dimethylamino)phenyl)-2-pyrazoline 

Relevant academic research and scientific papers

In vitro and in silico growth inhibitory, anti-ovarian & anti-lung carcinoma effects of 1,5 diarylpenta-1,4-dien-3-one as synthetically modified curcumin analogue

The synthesized 1,5 diarylpenta-1,4-dien-3-one derivatives (compounds 1-6) as synthetic curcumin analogues were tested for their potential anticancer activity against human ovarian and lung adenocarcinoma cells. The absorption, distribution, metabolism, excretion, and toxicity (ADMET/pharmacokinetic) parameters of all the compounds were predicted by admetSAR software. The pharmacokinetics, pharmacodynamics and bioactivity scores properties based on Lipinski rule and Ghose filter, calculated with the help of Molinspiration and ChemDraw. Molecular docking evaluation of all the compounds was also performed by using AutoDock Vina and iGEMDOCK against three most common human anticancer targets; epidermal growth factor receptor (EGFR), heat shock protein (Hsp 90-α), and vascular endothelial growth factor receptor-2 (VEGFR2). The obtained results were compared with the reference compound 7 and drugs 8-10 (7: GO-035; 8: Quinazolin; 9: Naquotinib and 10: Ribofuranuronamide). Finding indicates, all the compounds were potentially interacting with VEGFR2 through the average –9.1 binding energy (BE) with closer contact 1H-NMR). In vitro anti-proliferative activity was tested via MTT method against human ovarian carcinoma (PA-1) and human lung adenocarcinoma (A549) cells and further screened for apoptotic parameters such as nuclear fragmentation and ROS generation. Compound 4 exhibits good dose-dependent anti-proliferative activity (IC50 73 and 79.7 μM) against human ovarian carcinoma and human lung adenocarcinoma, respectively. Communicated by Ramaswamy H. Sarma.

Stereo- and regioselective photocycloaddition of extended alkenes using γ-cyclodextrin

Photoexcitation of dibenzalacetones (1a-d) in homogeneous media and solid state yields a mixture of products with poor conversions. Irradiation of the reactants complexed to γ-cyclodextrin predominantly affords a single dimer (syn adduct 6) despite the possibility for several monomeric and dimeric products. High selectivity in the cavitand-mediated reaction along with the structural characterization of the inclusion complex provides insight into the supramolecular interactions that drive the self-assembly of the host-guest system.

Sulfamic acid: An efficient, cost-effective and green catalyst for crossed-aldol condensation of ketones with aromatic aldehydes under solvent-free

Aromatic aldehydes undergo crossed-aldol condensation with ketones in the presence of catalytic amount of sulfamic acid (SA) to afford the corresponding α, β-unsaturated aldol products under solvent-free conditions in good to high yields at 45-80 °C.

Study of substituent effects in substituted dibenzal acetones

The present work involves a detailed study of the ultra-violet absorption spectra of various substituted dibenzylidene ketones derived from acetone, ethyl methyl ketone, diethyl ketone, cyclopentanone and cyclohexanone by condensing with several meta- and para-substituted benzaldehydes in n-hexane and in ethanol to ascertain the transition dominant in these solvents. These ketones exist as equilibrium mixtures of s-cis, cis and s-cis, trans conformations. The ultraviolet absorption spectra of the ketones exhibit two bands due to π* ← π transition around 250 and 320 nm. The 320 nm band is prominent in all the cases. There is no indication of π* ← n transition in any of the spectra. The 320 nm band is structureless in all the cases except those shown by the dibenzylidene ketones derived from cyclopentanone in hexane. Therefore it can be inferred that the dibenzylide ketones derived from all the ketones except those derived from cyclopentanone are non-planar.

Curcumin analogs with anti-tumor and anti-angiogenic properties

The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.