66887-16-9Relevant articles and documents
Direct Reductive N-Functionalization of Aliphatic Nitro Compounds
Rauser, Marian,Ascheberg, Christoph,Niggemann, Meike
, p. 3970 - 3974 (2018/02/26)
The first general protocol for the direct reductive N-functionalization of aliphatic nitro compounds is presented. The nitro group is partially reduced to a nitrenoid, with a mild and readily available combination of B2pin2 and zinc organyls. Thereby, the formation of an unstable nitroso intermediate is avoided, which has so far severely limited reductive transformations of aliphatic nitro compounds. The reaction is concluded by an electrophilic amination of zinc organyls.
ALKYLATION OF N-SUBSTITUTED AMIDES OF CARBOXYLIC ACIDS BY STYRENE IN THE PRESENCE OF POTASSIUM HYDROXIDE
Malkhasyan, A. Ts.,Nazaryan, E. M.,Mirakyan, S. M.,Martirosyan, G. T.
, p. 2195 - 2197 (2007/10/02)
The reaction of N,N-dimethylacetamide with styrene in the dimethyl sulfoxide-potassium hydroxide system leads to the formation of α-C-alkylated reaction products.It was established that substitution of the dimethyl sulfoxide by the initial amide makes it possible to increase the total yield of the monoalkylation and dialkylation products to 87 percent.From N-ethylacetamide and styrene under analogous conditions the N-alkylation product was obtained (37 percent).
