66890-58-2

Upstream product

• 103323-61-1 1-bromo-2,5-dimethoxy-3,4-dimethylbenzene 
• 95-65-8 3,4-Dimethylphenol 
• 836-38-4 4-(benzyloxy)-1,2-dimethylbenzene 
• 86489-95-4 2,5-dimethoxy-3,4-dimethylbenzaldehyde 
• 66890-56-0 Acetic acid 4-acetoxy-6-benzyloxy-2,3-dimethyl-phenyl ester 
• 66890-55-9 5-Benzyloxy-2,3-dimethyl-[1,4]benzoquinone 
• 66890-59-3 1-Benzyloxy-2,5-dimethoxy-3,4-dimethyl-benzene 

Downstream Products

• 1016978-05-4 1-(2',5'-dinitrophenoxy)-3,4-dimethyl-2,5-dimethoxybenzene 
• 144562-73-2 8-Pyridin-3-yl-2-[1-(2,3,6-trimethoxy-4,5-dimethyl-phenyl)-meth-(E)-ylidene]-octanoic acid ethyl ester 
• 144562-69-6 7-Pyridin-3-yl-2-[1-(2,3,6-trimethoxy-4,5-dimethyl-phenyl)-meth-(E)-ylidene]-heptanoic acid ethyl ester 
• 180777-96-2 (E)-3-(2,5,6-trimethoxy-3,4-dimethylphenyl)-2-[6-(3-pyridyl)hexyl]-2-propenoic acid 
• 144562-87-8 (E)-3-(2,5,6-trimethoxy-3,4-dimethylphenyl)-2-[5-(3-pyridyl)pentyl]-2-propenoic acid 
• 144563-06-4 (E)-3-(2-Methoxy-5,6-dimethyl-1,4-benzoquinon-3-yl)-2-[5-(pyridin-3-yl)pentyl]-2-propenoic acid 
• 180778-12-5 2,3,6-Trimethoxy-4,5-dimethyl-benzaldehyde 
• 783332-92-3 5-(2-acetoxy-3,6-dimethoxy-4,5-dimethylphenyl)-3-methylpent-2-enoic acid 
• 783332-93-4 2-((E)-5-hydroxy-3-methylpent-3-enyl)-3,6-dimethoxy-4,5-dimethyl phenol 
• 783332-91-2 acetic acid 2,5-dimethoxy-3,4-dimethyl-6-(3-oxobutyl)phenyl ester 

Relevant academic research and scientific papers

Synthesis and Evaluation of Novel 7- and 8-Aminophenoxazinones for the Detection of β-Alanine Aminopeptidase Activity and the Reliable Identification of Pseudomonas aeruginosa in Clinical Samples

A series of novel 8-aminophenoxazin-3-one and 7-aminophenoxazin-3-one chromogens and their corresponding β-alanine derivatives were synthesized and evaluated for their ability to detect β-alanyl aminopeptidase activity in bacteria known to hydrolyze β-ala

Enzymatic substrates derived from phenoxazinone and their use as developer in detection of microorganisms with peptidase activity

Novel enzymatic substrates of the general formula below: reaction media containing the same and their use for detecting and/or identifying and/or quantifying microorganisms expressing at least one peptidase activity.

Synthesis and testing of chromogenic phenoxazinone substrates for β-alanyl aminopeptidase

Novel 7-N-(β-alanyl)aminophenoxazin-3-one salts 27a-d have been synthesized and tested as chromogenic substrates for β-alanyl aminopeptidase, which is present in Pseudomonas aeruginosa, the most common respiratory pathogen in patients with cystic fibrosis. The biological results show that 7-N-(β-alanyl)amino-1-pentylphenoxazin-3-one trifluoroacetate salt 27a is a chromogenic substrate for this bacterium, with a low degree of diffusion in nutrient media for growing bacterial cultures and a bright red colour, making it easily distinguishable from the agar background. This journal is The Royal Society of Chemistry.

Synthesis of chiral chromans by the Pd-catalyzed asymmetric allylic alkylation (AAA): Scope, mechanism, and applications

The Pd-catalyzed asymmetric allylic alkylation (AAA) of phenol allyl carbonates serves as an efficient strategy to construct the allylic C-O bond allowing access to chiral chromans in up to 98% ee. The effect of pH and the influence of olefin geometry, as well as substitution pattern on the ee and the absolute configuration of the chiral chromans were explored in detail. These observations suggest a mechanism involving the cyclization of the more reactive π-allyl palladium diastereomeric intermediate as the enantiodiscriminating step (Curtin-Hammett conditions). This methodology led to the enantioselective synthesis of the vitamin E core, the first enantioselective total synthesis of (+)-clusifoliol and (-)-siccanin, and the synthesis of an advanced intermediate toward (+)-rhododaurichromanic acid A.