66898-03-1

Basic information

• Product Name: Benzenesulfonamide, 4-methyl-N-(1-methyl-1-phenylethyl)-
• CAS NO: 66898-03-1
• Molecular Formula: C16H19NO2S
• Molecular Weight: 289.398
• Mol File: 66898-03-1.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 4-methyl-N-(1-methyl-1-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 4-methyl-N-(1-methyl-1-phenylethyl)-(66898-03-1)
• EPA Substance Registry System: Benzenesulfonamide, 4-methyl-N-(1-methyl-1-phenylethyl)-(66898-03-1)

Safety Data

• Hazardous Substances Data: 66898-03-1(Hazardous Substances Data)

Upstream product

• 98-82-8 Isopropylbenzene 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 21849-40-1 dibromamine-T 
• 127-65-1 chloroamine-T 
• 98-59-9 p-toluenesulfonyl chloride 
• 100-41-4 ethylbenzene 
• 41085-71-6 bromamine T 
• 7080-50-4 chloramine-T hydrate 
• 7774-60-9 α,α-dimethylbenzyl 2-methylpropanoate 
• 70-55-3 toluene-4-sulfonamide 
• 4019-54-9 isopropylbenzene-d1 
• 98-83-9 isopropenylbenzene 
• 617-94-7 1-methyl-1-phenylethyl alcohol 
• 32366-26-0 cumyl azide 

Downstream Products

• 936841-47-3 4-methyl-2-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide 
• 936841-25-7 2-iodo-4-methyl-N-(2-phenylpropan-2-yl)benzenesulfonamide 
• 66897-71-0 N-Allyl-4-methyl-N-(1-methyl-1-phenyl-ethyl)-benzenesulfonamide 

Relevant articles and documents

Halogen-Bond-Induced Consecutive Csp3-H Aminations via Hydrogen Atom Transfer Relay Strategy

The utilization of a halogen bond in a number of chemical fields is well-known. Surprisingly, the incorporation of this useful noncovalent interaction in chemical reaction engineering is rare. We disclose here an uncommon use of halogen bonding to induce intermolecular Csp3-H amination while enabling a hydrogen atom transfer relay strategy to access privileged pyrrolidine structures directly from alkanes. Mechanistic studies support the presence of multiple halogen bond interactions at distinct reaction stages.

NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA

The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the description. The compounds of formula (I) are inhibitors of the YAP/TAZ-TEAD intera

A versatile tripodal Cu(I) reagent for C-N bond construction via nitrene-transfer chemistry: Catalytic perspectives and mechanistic insights on C-H aminations/amidinations and olefin aziridinations

A CuI catalyst (1), supported by a framework of strongly basic guanidinato moieties, mediates nitrene-transfer from PhI=NR sources to a wide variety of aliphatic hydrocarbons (C-H amination or amidination in the presence of nitriles) and olefins (aziridination). Product profiles are consistent with a stepwise rather than concerted C-N bond formation. Mechanistic investigations with the aid of Hammett plots, kinetic isotope effects, labeled stereochemical probes, and radical traps and clocks allow us to conclude that carboradical intermediates play a major role and are generated by hydrogen-atom abstraction from substrate C-H bonds or initial nitrene-addition to one of the olefinic carbons. Subsequent processes include solvent-caged radical recombination to afford the major amination and aziridination products but also one-electron oxidation of diffusively free carboradicals to generate amidination products due to carbocation participation. Analyses of metal- and ligand-centered events by variable temperature electrospray mass spectrometry, cyclic voltammetry, and electron paramagnetic resonance spectroscopy, coupled with computational studies, indicate that an active, but still elusive, copper-nitrene (S = 1) intermediate initially abstracts a hydrogen atom from, or adds nitrene to, C-H and C=C bonds, respectively, followed by a spin flip and radical rebound to afford intra- and intermolecular C-N containing products.