668980-22-1Relevant academic research and scientific papers
PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF
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Paragraph 0139; 0140, (2015/05/13)
Provided are piperazinyl pyrimidine derivatives of formula I having CCR4 antagonism, and the preparation method, pharmaceutical composition and use thereof in the preparation of a medicament. The medicament is useful for the treatment and preve
PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF
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Paragraph 0086-0087, (2014/12/09)
Provided are piperazinyl pyrimidine derivatives of formula I having CCR4 antagonism, and the preparation method, pharmaceutical composition and use thereof in the preparation of a medicament. The medicament is useful for the treatment and preve
Design and synthesis of a series of pyrido[2,3-d]pyrimidine derivatives as CCR4 antagonists
Gong, Hongwei,Qi, Hui,Sun, Wei,Zhang, Yang,Jiang, Dan,Xiao, Junhai,Yang, Xiaohong,Wang, Ying,Li, Song
, p. 9961 - 9970 (2012/11/13)
A series of pyrido[2,3-d]pyrimidine derivatives were designed and synthesized based on known CC chemokine receptor 4 (CCR4) antagonists. The activities of all the newly synthesized compounds were evaluated using a chemotaxis inhibition assay. Compound 6b
Core exploration in optimization of chemokine receptor CCR4 antagonists
Purandare, Ashok V.,Wan, Honghe,Somerville, John E.,Burke, Christine,Vaccaro, Wayne,Yang, XiaoXia,McIntyre, Kim W.,Poss, Michael A.
, p. 679 - 682 (2007/10/03)
The design, synthesis, and SAR studies of 'core' variations led to identification of novel, selective, and potent small molecule antagonist (22) of the CC chemokine receptor-4 (CCR4) with improved in vitro activity and liability profile. Compound 22 was e
Antagonists of chemokine receptors
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, (2008/06/13)
Compounds are provided which are antagonists of chemokine receptor activity. The compounds thereof have the structure including enantiomers, diastereomers, tautomers, pharmaceutically acceptable salts and solvates thereof wherein: A, B, D, E, X and Y are
