668980-23-2Relevant academic research and scientific papers
Design and synthesis of a series of pyrido[2,3-d]pyrimidine derivatives as CCR4 antagonists
Gong, Hongwei,Qi, Hui,Sun, Wei,Zhang, Yang,Jiang, Dan,Xiao, Junhai,Yang, Xiaohong,Wang, Ying,Li, Song
, p. 9961 - 9970 (2012)
A series of pyrido[2,3-d]pyrimidine derivatives were designed and synthesized based on known CC chemokine receptor 4 (CCR4) antagonists. The activities of all the newly synthesized compounds were evaluated using a chemotaxis inhibition assay. Compound 6b
PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF
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, (2015/05/13)
Provided are piperazinyl pyrimidine derivatives of formula I having CCR4 antagonism, and the preparation method, pharmaceutical composition and use thereof in the preparation of a medicament. The medicament is useful for the treatment and preve
PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF
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, (2014/12/09)
Provided are piperazinyl pyrimidine derivatives of formula I having CCR4 antagonism, and the preparation method, pharmaceutical composition and use thereof in the preparation of a medicament. The medicament is useful for the treatment and preve
Core exploration in optimization of chemokine receptor CCR4 antagonists
Purandare, Ashok V.,Wan, Honghe,Somerville, John E.,Burke, Christine,Vaccaro, Wayne,Yang, XiaoXia,McIntyre, Kim W.,Poss, Michael A.
, p. 679 - 682 (2007/10/03)
The design, synthesis, and SAR studies of 'core' variations led to identification of novel, selective, and potent small molecule antagonist (22) of the CC chemokine receptor-4 (CCR4) with improved in vitro activity and liability profile. Compound 22 was e
