66899-05-6Relevant articles and documents
Palladium-catalyzed dehydrative allylation of hypophosphorous acid with allylic alcohols
Bravo-Altamirano, Karla,Montchamp, Jean-Luc
, p. 4169 - 4171 (2006)
A novel palladium-catalyzed allylation of H3PO2 with allylic alcohols is described. The phosphorus-carbon bond-forming reaction produces allylic-H-phosphinic acids and water, in the absence of additives. Primary H-phosphinic acids are obtained in excellent yields, whereas secondary H-phosphinic acids react sluggishly. A reusable polymer-supported catalyst is also described. The reaction provides an environmentally sound approach to H-phosphinic acids.
Design, synthesis, and biological evaluation of phosphinopeptides against Trypanosoma cruzi targeting trypanothione biosynthesis
Ravaschino, Esteban L.,Docampo, Roberta,Rodriguez, Juan B.
, p. 426 - 435 (2007/10/03)
As a part of our project aimed at the search for new safe chemotherapeutic and chemoprophylactic agents against American trypanosomiasis (Chagas's disease); a series of phosphinopeptides structurally related to glutathione was designed, synthesized, and evaluated as antiproliferative agents against the parasite responsible for this disease, the hemoflagellated protozoan Trypanosoma cruzi. The rationale for the synthesis of these compounds was supported on the basis that the presence of the phosphinic acid moiety would mimic the tetrahedral transition state of trypanothione synthase (TryS), a typical C:N ligase, and the molecular target of these drugs. Of the designed compounds, 53 and 54 were potent growth inhibitors against the clinically more relevant form of T. cruzi (amastigotes) growing in myoblasts. The efficacy for these drugs was comparable to that exhibited by the well-known antiparasitic agent WC-9. The simple phosphinopeptide structure found as a pharmacophore in the present study constitutes a starting point for the development of straightforward optimized drugs.
REACTION BETWEEN 2-HYDROXY ESTERS OF HYPOPHOSPHOROUS ACID AND ALCOHOLS
Devedjiev, I.,Borisov, G.
, p. 37 - 42 (2007/10/02)
A study of the reaction between esters of hypophosphorous acid and alcohols is carried out.It has been established that the 2-hydroxy esters of hypophosphorous acid react with alcohols as a result of which phosphonous acids are formed.A possible scheme of this reaction is suggested.
