66909-30-6

Basic information

• Product Name: 2-Chloro-5-methylpyridine-3-carboxylic acid
• Synonyms: 2-Chloro-5-methylpyridine-3-carboxylic acid;2-chloro-5-methyl-3-Pyridinecarboxylic acid;2-Chloro-5-methylpyridin-3-ylcarboxylic acid;2-Chloro-5-Methylnicotinic Acid(WX614044)
• CAS NO: 66909-30-6
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58
• Product Categories: pharmacetical;Heterocycle-Pyridine series
• Mol File: 66909-30-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 331.175 °C at 760 mmHg
• Flash Point: 154.089 °C
• Appearance: /
• Density: 1.39 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Chloro-5-methylpyridine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-methylpyridine-3-carboxylic acid(66909-30-6)
• EPA Substance Registry System: 2-Chloro-5-methylpyridine-3-carboxylic acid(66909-30-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 66909-30-6(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-methylpyridine-3-carboxylic acid is a chemical compound that belongs to the class of pyridine carboxylic acids. It is a white to yellow solid, and its molecular formula is C7H6ClNO2. The compound is used in the synthesis of pharmaceuticals and agrochemicals. It contains a chloro substituent at the 2-position, a methyl group at the 5-position, and a carboxylic acid group at the 3-position of the pyridine ring. 2-Chloro-5-methylpyridine-3-carboxylic acid is used as a building block in organic synthesis and is also a key intermediate in the production of various drugs and crop protection agents.

InChI:InChI=1/C7H6ClNO2/c1-4-2-5(7(10)11)6(8)9-3-4/h2-3H,1H3,(H,10,11)

Upstream product

• 124-38-9 carbon dioxide 
• 18368-64-4 2-chloro-5-methylpyridine 
• 65169-43-9 2-chloro-5-methylnicotinic acid methyl ester 

Downstream Products

• 894074-85-2 ethyl 2-chloro-5-methylpyridine-3-carboxylate 
• 65169-43-9 2-chloro-5-methylnicotinic acid methyl ester 

Relevant articles and documents

AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS

A compound of formula (I) wherein : - one of the groups G1represents a nitrogen atom or a group CRc and the other represents a group CRc; - G2 represents a nitrogen atom or a group CRd; - R1 represents a group selected from hydrogen atoms, halogen atoms, C1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C3-8 cycloalkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; - R2 represents a group selected from hydrogen atoms, halogen atoms, hydroxyl groups, C1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, C1-4 alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C3-8 cycloalkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; - Ra, Rb and Rc independently represent groups selected from hydrogen atoms, halogen atoms, C1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C1-4alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; - Rd represents a group selected from hydrogen atoms, halogen atoms, hydroxyl groups, C1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C1-4 alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C3-8 cycloalkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; - one of the groups G3 and G4 is a nitrogen atom and the other is a CH group; - M is a hydrogen atom or an pharmaceutically acceptable cation with the proviso that, when at least one of the groups Ra and Rb represent a hydrogen atom and G2 is a group CRd, then Rd represents a groups selected from C1-4 alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, C3-8 cycloalkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; and the pharmaceutically acceptable salts and N-oxides thereof.

PYRIDOPYRIMIDINE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS

The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a PDE 4 mediated disease state.

NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS

This invention relates to nicotinamide derivative of general formula (I), in which R1, R2 and R3 have the meanings defined herein, and to compositions containing and the uses of such derivatives as PDE4 inhibitors.