66920-75-0

Basic information

• Product Name: 4-(1-naphthyl)-3-buten-2-one
• Synonyms: 4-(1-naphthyl)-3-buten-2-one;4-(1-Naphthalenyl)-3-buten-2-one;4-(1-Naphtyl)-3-butene-2-one;4-(naphthalen-1-yl)but-3-en-2-one
• CAS NO: 66920-75-0
• Molecular Formula: C₁₄H₁₂O
• Molecular Weight: 196.24448
• EINECS: 266-520-7
• Mol File: 66920-75-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 370°C at 760 mmHg
• Flash Point: 140.7°C
• Appearance: /
• Density: 1.101g/cm³
• Vapor Pressure: 1.14E-05mmHg at 25°C
• Refractive Index: 1.645
• CAS DataBase Reference: 4-(1-naphthyl)-3-buten-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-naphthyl)-3-buten-2-one(66920-75-0)
• EPA Substance Registry System: 4-(1-naphthyl)-3-buten-2-one(66920-75-0)

Safety Data

• Hazardous Substances Data: 66920-75-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H12O/c1-11(15)9-10-13-7-4-6-12-5-2-3-8-14(12)13/h2-10H,1H3

Upstream product

• 6833-19-8 1-naphthanilide 
• 66-77-3 1-naphthaldehyde 
• 67-64-1 acetone 
• 27309-70-2 tris(1-naphthyl)stilbane 
• 78-94-4 methyl vinyl ketone 

Downstream Products

• 144128-68-7 5-(naphthalene-1-yl)cyclohexane-1,3-dione 
• 101081-58-7 1-(3,5-dichloro-phenyl)-naphthalene 
• 101272-82-6 3-chloro-5-[1]naphthyl-cyclohex-2-enone 
• 1629212-11-8 C₃₂H₃₄N₂O 
• 1418030-40-6 4-methyl-6-(naphthalen-1-yl)-2,10-diphenyl-2,3-diazaspiro[4.5]dec-3-ene-1,8-dione 
• 1416316-89-6 (E)-4-methoxy-N-((E)-4-(naphthalen-1-yl)but-3-en-2-ylidene)aniline 
• 1416317-22-0 (Z)-4-methoxy-N-((E)-4-(naphthalen-1-yl)but-3-en-2-ylidene)aniline 
• 1377071-34-5 (R)-dibenzyl 2-(1-(naphthalene-1-yl)-3-oxobutyl)malonate 
• 1353719-60-4 (S)-5-ethyl-5-((R)-1-(naphthalen-1-yl)-3-oxobutyl)-2-phenyloxazol-4(5H)-one 
• 1300750-04-2 triisopropyl[(5Z,7E)-4-(p-methoxybenzenesulfonyl)-8-(naphth-1-yl)-4-azaocta-5,7-dien-1-yn-6-yloxy]silane 

Relevant articles and documents

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Enzyme-catalyzed domino reaction: Efficient construction of spirocyclic oxindole skeleton using porcine pepsin

Pepsin from porcine gastric mucosa was used as a sustainable and environmentally friendly biocatalyst in the domino Knoevenagel/Michael/Michael reaction for the synthesis of spirooxindole derivatives in methanol. A wide range of isatins and α,β-unsaturated ketones reacting with malononitrile provided the corresponding products in yields of up to 99% with diastereoselectivities of up to >99:1 dr. This pepsin-catalyzed domino reaction provided a novel case of enzyme catalytic promiscuity.

Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures

To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.