66921-96-8

Upstream product

• 303-07-1 2,6-Dihydroxybenzoic acid 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 130157-38-9 2-(3-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylsulfanyl]-ethoxy}-propoxy)-6-{3-[2-((R)-2-tert-butoxycarbonylamino-propionylsulfanyl)-ethoxy]-propoxy}-benzoic acid 
• 130157-27-6 2-{3-[2-(2-Benzyloxycarbonylamino-acetylsulfanyl)-ethoxy]-propoxy}-6-{3-[2-((S)-2-tert-butoxycarbonylamino-propionylsulfanyl)-ethoxy]-propoxy}-benzoic acid tert-butyl ester 
• 130157-39-0 2-[3-(2-{(R)-2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylamino]-propionylsulfanyl}-ethoxy)-propoxy]-6-[3-(2-mercapto-ethoxy)-propoxy]-benzoic acid 
• 130157-25-4 2-{2-[2-(2-Benzyloxycarbonylamino-acetylsulfanyl)-ethoxy]-ethoxy}-6-{2-[2-((S)-2-tert-butoxycarbonylamino-propionylsulfanyl)-ethoxy]-ethoxy}-benzoic acid tert-butyl ester 
• 130157-26-5 2-[6-(2-Benzyloxycarbonylamino-acetylsulfanyl)-hexyloxy]-6-[6-((S)-2-tert-butoxycarbonylamino-propionylsulfanyl)-hexyloxy]-benzoic acid tert-butyl ester 
• 131326-44-8 2-{3-[2-(2-Benzyloxycarbonylamino-acetylsulfanyl)-ethoxy]-propoxy}-6-[3-(2-mercapto-ethoxy)-propoxy]-benzoic acid tert-butyl ester 
• 131326-46-0 2-{2-[2-(2-Benzyloxycarbonylamino-acetylsulfanyl)-ethoxy]-ethoxy}-6-[2-(2-mercapto-ethoxy)-ethoxy]-benzoic acid tert-butyl ester 
• 131326-45-9 2-[6-(2-Benzyloxycarbonylamino-acetylsulfanyl)-hexyloxy]-6-(6-mercapto-hexyloxy)-benzoic acid tert-butyl ester 
• 131326-30-2 2,6-Bis-[3-(2-acetylsulfanyl-ethoxy)-propoxy]-benzoic acid tert-butyl ester 
• 131326-43-7 2,6-Bis-[2-(2-acetylsulfanyl-ethoxy)-ethoxy]-benzoic acid tert-butyl ester 
• 131326-37-9 2,6-Bis-(6-acetylsulfanyl-hexyloxy)-benzoic acid tert-butyl ester 
• 130157-19-6 2,6-Bis-[3-(2-mercapto-ethoxy)-propoxy]-benzoic acid tert-butyl ester 
• 131326-28-8 2,6-Bis-[3-(2-hydroxy-ethoxy)-propoxy]-benzoic acid tert-butyl ester 
• 130157-17-4 2,6-Bis-[2-(2-mercapto-ethoxy)-ethoxy]-benzoic acid tert-butyl ester 

Relevant academic research and scientific papers

PENICILLIN-BINDING PROTEIN INHIBITORS

Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds describ

A NEW MACROCYCLIC DIACID WITH BALANCED CONFORMATIONAL FLEXIBILITY AND PREORGANIZATION

Macrocyclic diacid 1 was designed and synthesized as an effective catalyst for hemiacetal cleavage.Molecular modelling studies (using Clark Still's MacroModel) show that 1 has many accessible low energy conformations with various degrees of carboxyl group

Acceleration of Hemiacetal Cleavage through Hydrogen Bonding: A New Synthetic Catalyst with Balanced Conformational Flexibility and Preorganization

Hemiacetal cleavage catalyst 1 was designed, synthesized, and shown to be effective in promoting glycolaldehyde dimer dissociation and tetramethylglucose mutarotation.

PEPTIDE BOND FORMATION USING AN ENZYME MIMICKING APPROACH

A man-made enzyme-model based on a concerted proton transfer step (bifunctional catalysis) which mimics the corresponding step in non-ribosomal peptide synthesis was developed.Important features of the model are the following: (a) a bifunctional acid-base catalyst for the thiolester aminolysis rate acceleration, (b) two thiol-containing arms mimicking the "swinging arms" of the enzyme, and (c) symmetry elements so that the process can be iterated with consequent formation of the polypeptide chain.Peptide bond formation was obtained by intramolecularly catalyzed thiolester aminolysis to give 5 in 80percent isolated yield (Scheme IV, V) and with at least a 103-fold rate acceleration in comparison with the corresponding non catalyzed process (4 -> 6)(Scheme IV, Table 1).The reaction is also 4-20 times faster than the analogous process 4 -> 6 run in the presence of 0.1M external catalyst (Et3N-ButCOOH or 2-Pyridone).Important structural and reaction parameters are discussed.A second intramolecular aminolysis reaction gave tripeptide 8 in lower yield (35percent) because of higher steric congestion in the transition state.